scholarly journals Rapid Production of PDMS Microdevices for Electrodriven Separations and Microfluidics by 3D-Printed Scaffold Removal

Separations ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 67
Author(s):  
Alena Šustková ◽  
Klára Konderlová ◽  
Ester Drastíková ◽  
Stefan Sützl ◽  
Lenka Hárendarčíková ◽  
...  
Keyword(s):  
Organic Dyes ◽  
Microfluidic Devices ◽  
Proof Of Concept ◽  
Magnetic Microparticles ◽  
Mechanical Removal ◽  
Glass Slides ◽  
Rapid Production ◽  
3D Printed

In our work, we produced PDMS-based microfluidic devices by mechanical removal of 3D-printed scaffolds inserted in PDMS. Two setups leading to the fabrication of monolithic PDMS-based microdevices and bonded (or stamped) PDMS-based microdevices were designed. In the monolithic devices, the 3D-printed scaffolds were fully inserted in the PDMS and then carefully removed. The bonded devices were produced by forming imprints of the 3D-printed scaffolds in PDMS, followed by bonding the PDMS parts to glass slides. All these microfluidic devices were then successfully employed in three proof-of-concept applications: capture of magnetic microparticles, formation of droplets, and isotachophoresis separation of model organic dyes.

scholarly journals Strategy for fast manufacturing of 3D hydrodynamic focusing multilayer microfluidic chips and its application for flow-based synthesis of gold nanoparticles

2021 ◽  
Vol 25 (8) ◽  
Author(s):  
Yanwei Wang ◽  
Michael Seidel
Keyword(s):  
Gold Nanoparticles ◽  
Microfluidic Devices ◽  
Microfluidic Chips ◽  
Proof Of Concept ◽  
Hydrodynamic Focusing ◽  
Pressure Sensitive Adhesive ◽  
Pmma Sheet ◽  
Pressure Sensitive ◽  
Working Device ◽  
Channel Structures

AbstractFabrication of 3D microfluidic devices is normally quite expensive and tedious. A strategy was established to rapidly and effectively produce multilayer 3D microfluidic chips which are made of two layers of poly(methyl methacrylate) (PMMA) sheets and three layers of double-sided pressure sensitive adhesive (PSA) tapes. The channel structures were cut in each layer by cutting plotter before assembly. The structured channels were covered by a PMMA sheet on top and a PMMA carrier which contained threads to connect with tubing. A large variety of PMMA slides and PSA tapes can easily be designed and cut with the help of a cutting plotter. The microfluidic chip was manually assembled by a simple lamination process.The complete fabrication process from device design concept to working device can be completed in minutes without the need of expensive equipment such as laser, thermal lamination, and cleanroom. This rapid frabrication method was applied for design of a 3D hydrodynamic focusing device for synthesis of gold nanoparticles (AuNPs) as proof-of-concept. The fouling of AuNPs was prevented by means of a sheath flow. Different parameters such as flow rate and concentration of reagents were controlled to achieve AuNPs of various sizes. The sheet-based fabrication method offers a possibility to create complex microfluidic devices in a rapid, cheap and easy way.

Proof of Concept: The Use of Whole-Slide Images (WSI) for Peer Review of Tissues on Routine Regulatory Toxicology Studies

2021 ◽  
pp. 019262332098325
Author(s):  
Alys E. Bradley ◽  
Maurice G. Cary ◽  
Kaori Isobe ◽  
Stuart Naylor ◽  
Stephen Drew
Keyword(s):  
Peer Review ◽  
Proof Of Concept ◽  
Regulatory Toxicology ◽  
Glass Slides ◽  
Microscopic Findings ◽  
Slight Discrepancy ◽  
Whole Slide Images ◽  
Diagnostic Discrepancies

This Proof of Concept (POC) study was to assess whether assessment of whole slide images (WSI) of the 2 target tissues for a contemporaneous peer review can elicit concordant results to the findings generated by the Study Pathologist from the glass slides. Well-focused WSI of liver and spleen from 4 groups of mice, that had previously been diagnosed to be the target tissues by an experienced veterinary toxicologic pathologist examining glass slides, were independently reviewed by 3 veterinary pathologists with varying experience in assessment of WSIs. Diagnostic discrepancies were then reviewed by an experienced adjudicating pathologist. Assessment of microscopic findings using WSI showed concordance with the glass slides, with only slight discrepancy in severity grades noted. None of the lesions recorded by the Study pathologist were “missed” and no lesions were added by the pathologists evaluating WSIs, thus demonstrating equivalence of the WSI to glass slides for this study.

scholarly journals Preparation and Performance Evaluation of Duotone 3D-Printed Polyetheretherketone as Oral Prosthetic Materials: A Proof-of-Concept Study

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1949
Author(s):  
Ling Ding ◽  
Wei Lu ◽  
Jiaqi Zhang ◽  
Chuncheng Yang ◽  
Guofeng Wu
Keyword(s):  
Titanium Dioxide ◽  
Performance Evaluation ◽  
Mechanical Performance ◽  
Mechanical Tests ◽  
Flexural Properties ◽  
Proof Of Concept ◽  
Tooth Color ◽  
Dental Application ◽  
3D Printed ◽  
And Performance

Literature has reported the successful use of 3D printed polyetheretherketone (PEEK) to fabricate human body implants and oral prostheses. However, the current 3D printed PEEK (brown color) cannot mimic the vivid color of oral tissues and thus cannot meet the esthetical need for dental application. Therefore, titanium dioxide (TiO2) and ferric oxide (Fe2O3) were incorporated into PEEK to prepare a series of tooth-color and gingival-color PEEK composites in this study. Through color measurements and mechanical tests, the color value and mechanical performance of the 3D printed PEEK composites were evaluated. In addition, duotone PEEK specimens were printed by a double nozzle with an interface between tooth-color and gingival-color parts. The mechanical performance of duotone PEEK with two different interfaces (horizontal and vertical) was investigated. With the addition of TiO2 and Fe2O3, the colors of 3D printed PEEK composites become closer to that of dental shade guides. 3D printed PEEK composites generally demonstrated superior tensile and flexural properties and hence have great potential in the dental application. In addition, duotone 3D printed PEEK with a horizontal interfacial orientation presented better mechanical performance than that with a vertical one.

Automated calibration of 3D-printed microfluidic devices based on computer vision

2021 ◽  
Vol 15 (2) ◽  
pp. 024102
Author(s):  
Junchao Wang ◽  
Kaicong Liang ◽  
Naiyin Zhang ◽  
Hailong Yao ◽  
Tsung-Yi Ho ◽  
...  
Keyword(s):  
Computer Vision ◽  
Microfluidic Devices ◽  
Automated Calibration ◽  
3D Printed

scholarly journals 3D printed microfluidic devices with immunoaffinity monoliths for extraction of preterm birth biomarkers

2018 ◽  
Vol 411 (21) ◽  
pp. 5405-5413 ◽  
Author(s):  
Ellen K. Parker ◽  
Anna V. Nielsen ◽  
Michael J. Beauchamp ◽  
Haifa M. Almughamsi ◽  
Jacob B. Nielsen ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Microfluidic Devices ◽  
3D Printed

scholarly journals Closing the Loop - Recycling Plastic Waste

2021 ◽  
Author(s):  
◽  
Caitlin Bruce
Keyword(s):  
New Zealand ◽  
Additive Manufacturing ◽  
Circular Economy ◽  
Building Material ◽  
New Technologies ◽  
Plastic Waste ◽  
Proof Of Concept ◽  
Waste Production ◽  
Closing The Loop ◽  
3D Printed

<p>New Zealand is ranked among the top nations in waste production, including a million tonnes of plastic waste. Currently, there are methods for recycling plastic within New Zealand but these methods can be expensive and time-consuming, resulting in most of the plastic being thrown into the landfill. Because plastic does not fully degrade, it ends up in the ocean and other waterways, poisoning the water with toxins. The purpose of this research is to provide a solution to reducing plastic waste by creating an alternative method of recycling that utilises new technologies such as additive manufacturing, to create a building material that fits into the concept of the circular economy. The findings of this research explored the recycling of plastic by collecting plastic waste such as PLA (Polylactic Acid) from old 3D printed models. The plastic was recycled into filament for additive manufacturing (AM) and used to print building tile, establishing an initial proof of concept for the use of recycled plastic as a potential building material.</p>

Proof-of-concept for a segmented composite diving suit offering depth-independent thermal protection

2021 ◽  
Vol 51 (3) ◽  
pp. 295-298
Author(s):  
Aaron Demers ◽  
◽  
Shane Martin ◽  
Emil P Kartalov ◽  
◽  
...  
Keyword(s):  
Thermal Protection ◽  
Health Hazard ◽  
Organ Damage ◽  
Field Trials ◽  
Proof Of Concept ◽  
Major Health ◽  
3D Printed ◽  
Higher Temperature ◽  
3D Scans ◽  
Resistive Composite

Heat loss is a major health hazard for divers. It can lead to hypothermia, organ damage, unconsciousness, and eventually death. Hence, thermal protection is essential for diver safety. Typically, protection is provided by wetsuits made of bubbled neoprene. However, neoprene shrinks with depth and loses thermal insulation capability, while thick neoprene suits make swimming exhausting. Herein, a proof-of-concept is presented for a solution to both problems: a ‘K-suit’ made of thermally-resistive composite segments attached to a thin neoprene suit. The segments are made of hollow glass microspheres embedded in carrier polymer thermally cured in 3D-printed molds based on 3D-scans of the diver’s body. The K-suit was compared in field trials with a 7 mm commercial neoprene suit by diving in pairs, while automated dataloggers registered pressure and temperature inside and outside both suits. The K-suit demonstrated +4ºC higher temperature difference than the 7 mm neoprene. Also, divers reported that the K-suit had the ergonomics of a 3 mm neoprene suit. These preliminary results represent a proof-of-concept for the K-suit and promise further improvements with potential impact on diver safety.

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