The effect of supply channel structures on remanufacturing, pricing, and acquisition management

This paper developed an acquisition management problem in a Closed-Loop Supply chain (CLSC) network. This study determines optimal selling prices of brand-new and remanufactured products, wholesale prices, and acquisition prices in various distribution and collection channel structures. It shows that determining the best structure is highly affected by the model’s parameters, as well as the decision-makers’ objectives. Moreover, precious managerial insights from five different viewpoints have been provided for decision-makers in order to benefit considerably from various situations of remanufacturing and acquisition activities, as well as manufacturing and distribution activities. Simulation approach is employed for analyzing the proposed solutions in different conditions.

Tourism distribution in a transitional economy: Hotel ownership and distribution channels in Vietnam

<p>This thesis investigates how the different up-market hotel ownership modes establish distribution channels to reach domestic and international tourism markets in the context of Vietnam’s transitional economy, which has been transforming from a centrally planned to a socialist market oriented economy since 1986. It seeks to understand the current distribution channel structures of various hotel ownership modes; to explore the ways in which a number of factors influence distribution structures; and to examine the implications of these structures and factors for hotel and tourism development in Vietnam and in other economies with similar socio-political characteristics. A conceptual framework for hotel distribution channels is developed from a combination of the predominantly Western literature and the fragmented literature on hotel distribution in transition economies. The conceptual framework enables the researcher to investigate the linkages and relationships among the components that constitute the current Vietnamese hotel distribution systems. A qualitative approach is applied to address the supply-side issues of hotel distribution with data collected in the three largest urban cities located in the Northern, Central and Southern parts of Vietnam. The data collection methods were in-depth semi-structured interviews and document compilation. Different groups of participants from the Vietnam tourism industry including senior staff of sales and marketing of the four- and five-star hotels, international tour operators, high-ranking government officials of central and provincial authorities of tourism, key officers of trade organisations and academics from these cities were interviewed. The research presents the current distribution channel structures employed by four hotel ownership modes to reach domestic and international travellers. The findings also reveal that international joint venture and wholly foreign-owned hotels have effectively established their distribution channels to reach the international market. The entry of these international ownership modes as a result of Vietnam’s economic reform has forced state- and domestic privately-owned hotels to also build market-driven distribution structures. Economic restructuring in the context of Vietnam’s international integration has been the key element in creating the legal system, economic development, international tourist demand, technological advances, patterns of demand, hotel ownership and management modes that have driven the development of distribution. The research concludes that different hotel ownership and management modes and the distribution channel structures of up-market hotels are the products of Vietnam’s economic restructuring. The research suggests further economic renovation to meet the country’s commitments to international organisations, and to generate an equal tourism and hotel business environment in Vietnam.</p>

Tourism distribution in a transitional economy: Hotel ownership and distribution channels in Vietnam

<p>This thesis investigates how the different up-market hotel ownership modes establish distribution channels to reach domestic and international tourism markets in the context of Vietnam’s transitional economy, which has been transforming from a centrally planned to a socialist market oriented economy since 1986. It seeks to understand the current distribution channel structures of various hotel ownership modes; to explore the ways in which a number of factors influence distribution structures; and to examine the implications of these structures and factors for hotel and tourism development in Vietnam and in other economies with similar socio-political characteristics. A conceptual framework for hotel distribution channels is developed from a combination of the predominantly Western literature and the fragmented literature on hotel distribution in transition economies. The conceptual framework enables the researcher to investigate the linkages and relationships among the components that constitute the current Vietnamese hotel distribution systems. A qualitative approach is applied to address the supply-side issues of hotel distribution with data collected in the three largest urban cities located in the Northern, Central and Southern parts of Vietnam. The data collection methods were in-depth semi-structured interviews and document compilation. Different groups of participants from the Vietnam tourism industry including senior staff of sales and marketing of the four- and five-star hotels, international tour operators, high-ranking government officials of central and provincial authorities of tourism, key officers of trade organisations and academics from these cities were interviewed. The research presents the current distribution channel structures employed by four hotel ownership modes to reach domestic and international travellers. The findings also reveal that international joint venture and wholly foreign-owned hotels have effectively established their distribution channels to reach the international market. The entry of these international ownership modes as a result of Vietnam’s economic reform has forced state- and domestic privately-owned hotels to also build market-driven distribution structures. Economic restructuring in the context of Vietnam’s international integration has been the key element in creating the legal system, economic development, international tourist demand, technological advances, patterns of demand, hotel ownership and management modes that have driven the development of distribution. The research concludes that different hotel ownership and management modes and the distribution channel structures of up-market hotels are the products of Vietnam’s economic restructuring. The research suggests further economic renovation to meet the country’s commitments to international organisations, and to generate an equal tourism and hotel business environment in Vietnam.</p>

Tourism Distribution Channels in the Northern Tourist Circuit of Tanzania

<p>This study investigates the structure of tourism distribution channels in the northern tourist circuit of Tanzania. It explores factors influencing channel structures and also examines operational characteristics of the channels. It is a destination-based study that takes a supply-side approach. The study is based on in-depth interviews with different businesses across tourism sector at the destination. The northern tourist circuit is the heart of tourism industry in Tanzania; it is a core in a peripheral country. Tourists in the northern tourist circuit are primarily attracted by mountain climbing adventures, photographic and hunting safaris. Putting together different activities involved in a safari or adventure product requires the presence of ground tour operators. The former have links with all the suppliers at the destination and are the most knowledgeable about the destination among channel members in the destination. There is a complex relationship among channel members in the northern tourist circuit which partly contributes to the complexity of the distribution channels used. The majority of tourists who visit northern tourist circuit book their holidays through overseas agents; a few purchase directly from the suppliers. The majority of those who shop through overseas agents are package or customized tourists while most independent travellers buy their holidays directly, often making multiple purchases. Ground tour operators in Kenya are important channel members as well. This is because a significant number of tourists who visit the northern tourist circuit come through Kenya and ground tour operators there pass them down to their counterparts in Tanzania. Hunting tourists access the destinations through professional hunters, either directly or through overseas marketing agents. Secondary activities like cultural tourism rely more on "at destination" distribution as their drawing power is less than wildlife resources and adventure attractions. Factors which influence the structure of distribution in the northern tourist circuit include size of the business, nature of the attraction, tourists' preference, distance from market to destination, lack of capital and marketing knowledge. Channel performance is based on two main criteria: volume of clients the channel produces and the profit generated from the channel. Indirect channels produce more clients while direct channels are observed to generate more profit per client than indirect channels. Information technology is mainly used for creating awareness and communications. All the businesses interviewed have websites for those purposes.</p>

Tourism Distribution Channels in the Northern Tourist Circuit of Tanzania

<p>This study investigates the structure of tourism distribution channels in the northern tourist circuit of Tanzania. It explores factors influencing channel structures and also examines operational characteristics of the channels. It is a destination-based study that takes a supply-side approach. The study is based on in-depth interviews with different businesses across tourism sector at the destination. The northern tourist circuit is the heart of tourism industry in Tanzania; it is a core in a peripheral country. Tourists in the northern tourist circuit are primarily attracted by mountain climbing adventures, photographic and hunting safaris. Putting together different activities involved in a safari or adventure product requires the presence of ground tour operators. The former have links with all the suppliers at the destination and are the most knowledgeable about the destination among channel members in the destination. There is a complex relationship among channel members in the northern tourist circuit which partly contributes to the complexity of the distribution channels used. The majority of tourists who visit northern tourist circuit book their holidays through overseas agents; a few purchase directly from the suppliers. The majority of those who shop through overseas agents are package or customized tourists while most independent travellers buy their holidays directly, often making multiple purchases. Ground tour operators in Kenya are important channel members as well. This is because a significant number of tourists who visit the northern tourist circuit come through Kenya and ground tour operators there pass them down to their counterparts in Tanzania. Hunting tourists access the destinations through professional hunters, either directly or through overseas marketing agents. Secondary activities like cultural tourism rely more on "at destination" distribution as their drawing power is less than wildlife resources and adventure attractions. Factors which influence the structure of distribution in the northern tourist circuit include size of the business, nature of the attraction, tourists' preference, distance from market to destination, lack of capital and marketing knowledge. Channel performance is based on two main criteria: volume of clients the channel produces and the profit generated from the channel. Indirect channels produce more clients while direct channels are observed to generate more profit per client than indirect channels. Information technology is mainly used for creating awareness and communications. All the businesses interviewed have websites for those purposes.</p>

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175

Structures of the human lysosomal K+ channel TMEM175 in open and closed states revealed a novel architecture lacking the canonical K+ selectivity filter motif present in previously known K+ channel structures. A hydrophobic constriction composed of four isoleucine residues was resolved in the pore and proposed to serve as the gate in the closed state, and to confer ion selectivity in the open state. Here, we achieve higher-resolution structures of the open and closed states and employ molecular dynamics simulations to analyze the conducting properties of the putative open state, demonstrating that it is capable of permeating K+ ions at the expected rate. Monovalent cations must dehydrate significantly to penetrate the narrow hydrophobic constriction, but ion flow is assisted by a favorable electrostatic field generated by the protein that spans the length of the pore. The balance of these opposing energetic factors explains why permeation is feasible, and why TMEM175 is selective for K+ over Na+, despite the absence of the canonical selectivity filter. Accordingly, mutagenesis experiments reveal an exquisite sensitivity of the channel to perturbations that mitigate the constriction. Together, these data reveal a novel mechanism for selective permeation of ions by TMEM175 that is unlike that of other K+ channels.

Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues

Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal environments. The mechanotransduction process requires a range of special proteins termed mechanotransducers to convert mechanical forces into biochemical signals in cells. The Piezo proteins are mechanically activated nonselective cation channels and the largest plasma membrane ion channels reported thus far. The regulation of two family members, Piezo1 and Piezo2, has been reported to have essential functions in mechanosensation and transduction in different organs and tissues. Recently, the predominant contributions of the Piezo family were reported to occur in the skeletal system, especially in bone development and mechano-stimulated bone homeostasis. Here we review current studies focused on the tissue-specific functions of Piezo1 and Piezo2 in various backgrounds with special highlights on their importance in regulating skeletal cell mechanotransduction. In this review, we emphasize the diverse functions of Piezo1 and Piezo2 and related signaling pathways in osteoblast lineage cells and chondrocytes. We also summarize our current understanding of Piezo channel structures and the key findings about PIEZO gene mutations in human diseases.

Channel Structures of Online Retail Platforms

Problem definition: This paper investigates the channel choice problem of an online platform that exerts service effort to enhance the demand in its sales channels. Academic/practical relevance: In the existing literature on the channel structure of an online retail platform, it is usually assumed that a manufacturer sells through either the platform’s agency or reselling channel but not both. In practice, many manufacturers sell the same products through both channels of the same online retail platform, a phenomenon that cannot be explained by the existing theory. Moreover, online retail platforms routinely invest in retail services that enhance the demand in their sales channels. Methodology: We develop a game-theoretic model to investigate the equilibrium channel choice, wholesale price, and retail quantity decisions. We also conduct sensitivity analysis to evaluate the impact of some parameters on the equilibrium. Results: We derive conditions under which each of the three channel structures (agency channel, reselling channel, and dual channel) emerges in equilibrium. We show that the wholesale price in the reselling channel is reduced because of the addition of the agency channel even when both channels are equally efficient, which extends the wholesale price effect because of the addition of a less efficient direct channel in the supplier encroachment literature. Our analysis highlights the flexibility of a dual channel for firms to shift sales between the two channels, which could increase the retail platform’s incentive to exert service effort. Managerial implications: Our study provides useful insights to managers to understand and make channel choice decisions in supply chains with manufacturers selling through online retail platforms.

Using a Modified SERVQUAL Approach to Assess the Quality of Supply Chain Services in Greek Online Supermarkets

Background: The purpose of this paper is to study customer satisfaction concerning orders from online supermarkets, which have recently boomed to fulfil the increased needs of customers during the COVID-19 pandemic. The service quality, as well as aspects of the logistics efficiency, are being examined, and the gaps between the expectations of people using these services and their perceptions about the received services are being evaluated. Methods: A modified approach of the well-known model SERVQUAL is suggested and used in the case of Greek online supermarkets. Thus, an initial contribution of this paper is the formulation of a framework which can be used to assess the quality of B2C logistics services. Results: The results show that customers’ expectations are exceeding their experiential perceptions in all the examined fields, and therefore there is room for substantial improvement. The study identified areas in which supermarkets’ online shops are close to meeting customer expectations and areas in which they fall far short. Conclusions: Competition is expected to become more intense and efficient supply chains that provide services of high quality will have a determinant role to play. Moreover, online supermarkets will have to rethink of their omni-channel structures to maintain and increase their market share. This is of particular importance during turbulent times such as the ones we are experiencing now.