Unveiling the Influence of Non-Toxic Fluorinated Ionic Liquids Aqueous Solutions in the Encapsulation and Stability of Lysozyme

Proteins are bioactive compounds with high potential to be applied in the biopharmaceutical industry, food science and as biocatalysts. However, protein stability is very difficult to maintain outside of the native environment, which hinders their applications. Fluorinated ionic liquids (FILs) are a promising family of surface-active ionic liquids (SAILs) that have an amphiphilic behavior and the ability to self-aggregate in aqueous solutions by the formation of colloidal systems. In this work, the protein lysozyme was selected to infer on the influence of FILs in its stability and activity. Then, the cytotoxicity of FILs was determined to evaluate their biocompatibility, concluding that the selected compounds have neglected cytotoxicity. Therefore, UV–visible spectroscopy was used to infer the FIL-lysozyme interactions, concluding that the predominant interaction is the encapsulation of the lysozyme by FILs. The encapsulation efficiency was also tested, which highly depends on the concentration and anion of FIL. Finally, the bioactivity and thermal stability of lysozyme were evaluated, and the encapsulated lysozyme keeps its activity and thermal stability, concluding that FILs can be a potential stabilizer to be used in protein-based delivery systems.

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Drug Anion Based Surface Active Ionic Liquids: Molecular Interactions, Surface Activity and Micellization Behavior in Aqueous Solutions

Journal of Molecular Liquids ◽

10.1016/j.molliq.2021.116345 ◽

2021 ◽

pp. 116345

Author(s):

Nandhibatla V Sastry ◽

Pooja A Trivedi

Keyword(s):

Ionic Liquids ◽

Aqueous Solutions ◽

Surface Activity ◽

Molecular Interactions ◽

Surface Active ◽

Micellization Behavior

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Study of Preparation and Thermal Stability of Cyano-Functionalized Imidazolium Type Ionic Liquids

Asian Journal of Chemistry ◽

10.14233/ajchem.2013.14098 ◽

2013 ◽

Vol 25 (8) ◽

pp. 4779-4782 ◽

Cited By ~ 3

Author(s):

W.D. Liang ◽

H.F. Li ◽

G.J. Gou ◽

A.Q. Wang

Keyword(s):

Thermal Stability ◽

Ionic Liquids ◽

Thermal Stability Of

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Thermal Stability of Ionic Liquids in Nitrogen and Air Environments

The Journal of Chemical Thermodynamics ◽

10.1016/j.jct.2021.106560 ◽

2021 ◽

pp. 106560

Author(s):

Yong Huang ◽

Zhichao Chen ◽

Jacob M. Crosthwaite ◽

Sudhir N.V.K. Aki ◽

Joan F. Brennecke

Keyword(s):

Thermal Stability ◽

Ionic Liquids ◽

Thermal Stability Of

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Model-free kinetics applied to evaluate the long-term thermal stability of three [NTf2] anion-based ionic liquids

Thermochimica Acta ◽

10.1016/j.tca.2017.08.002 ◽

2017 ◽

Vol 656 ◽

pp. 70-84 ◽

Cited By ~ 2

Author(s):

D. Blanco ◽

P. Oulego ◽

D. Ramos ◽

B. Fernández ◽

J.M. Cuetos

Keyword(s):

Thermal Stability ◽

Ionic Liquids ◽

Model Free ◽

Model Free Kinetics ◽

Thermal Stability Of

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Syntheses, Crystal Structures and Thermal Stability of Co(II) and Zn(II) Complexes with Ethyl Carbazate

Zeitschrift für Naturforschung B ◽

10.1515/znb-2005-0505 ◽

2005 ◽

Vol 60 (5) ◽

pp. 505-510 ◽

Cited By ~ 12

Author(s):

Tong-Lai Zhang ◽

Jiang-Chuang Song ◽

Jian-Guo Zhang ◽

Gui-Xia Ma ◽

Kai-Bei Yu

Keyword(s):

Thermal Stability ◽

Aqueous Solutions ◽

Diffraction Analysis ◽

Single Crystals ◽

Slow Evaporation ◽

X Ray Diffraction ◽

Element Analysis ◽

Thermal Stabilities ◽

X Ray ◽

Thermal Stability Of

Cobalt(II) and zinc(II) complexes of ethyl carbazate (ECZ), [Co(ECZ)3](NO3)2 and [Zn(ECZ)3] (NO3)2, were synthesized. Single crystals of these two compounds were grown from aqueous solutions using a slow evaporation method. Their structures have been determined by X-ray diffraction analysis. Both of them are monoclinic with space group P21/n. The complexes are further characterized by element analysis and IR measurements. Their thermal stabilities are studied by using TG-DTG, DSC techniques. When heated to 350 °C, only metal oxide was left for both complexes.

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Preparation and thermal stability of optically active 1,2,4-triazolium-based ionic liquids

ARKIVOC ◽

10.3998/ark.5550190.0013.823 ◽

2012 ◽

Vol 2012 (8) ◽

pp. 262-281 ◽

Cited By ~ 6

Author(s):

Paweł Borowiecki ◽

Marcin Poterała ◽

Jan Maurin ◽

Monika Wielechowska ◽

Jan Plenkiewicz

Keyword(s):

Thermal Stability ◽

Ionic Liquids ◽

Optically Active ◽

Thermal Stability Of

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Effect of High Temperature on the Electrochemical and Optical Properties of Emeraldine Salt Doped with DBSA and Sulfuric Acid

Journal of Chemistry ◽

10.1155/2015/826358 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Salma Gul ◽

Anwar-ul-Haq Ali Shah ◽

Salma Bilal

Keyword(s):

Thermal Stability ◽

Cyclic Voltammetry ◽

Sulfuric Acid ◽

Effect Of Temperature ◽

Visible Spectroscopy ◽

Emeraldine Salt ◽

Higher Temperature ◽

Stability Effect ◽

Thermal Stability Of ◽

Comprehensive Study

A comprehensive study of thermally treated polyaniline in its emeraldine salt form is presented here. It offers an understanding of the thermal stability of the polymer. Emeraldine salt was prepared by a novel emulsion polymerization pathway using dodecylbenzene sulfonic acid and sulfuric acid together as dopants. The effect of temperature and heating rate on the degradation of this emeraldine salt was studied via thermogravimetric analysis. The thermally analyzed sample was collected at various temperatures, that is, 250, 490, 500, and 1000°C. The gradual changes in the structure of the emeraldine salt were followed through cyclic voltammetry, Fourier transform infrared spectroscopy, and ultraviolet-visible spectroscopy. Results demonstrate that emeraldine salt shows high thermal stability up to 500°C. This is much higher working temperature for the use of emeraldine salt in higher temperature applications. Further heat treatment seems to induce deprotonation in emeraldine salt. Cyclic voltammetry and ultraviolet-visible spectroscopy revealed that complete deprotonation takes place at 1000°C where it loses its electrical conductivity. It is interesting to note that after the elimination of the dopants, the basic backbone of emeraldine salt was not destroyed. The results reveal that the dopants employed have a stability effect on the skeleton of emeraldine salt.

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