scholarly journals Antagonistic Effects of Enrofloxacin on Carbendazim-Induced Developmental Toxicity in Zebrafish Embryos

Toxics ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 349
Author(s):  
Ruiqi Fan ◽  
Wanjun Zhang ◽  
Li Jia ◽  
Sunlin Luo ◽  
Ying Liu ◽  
...  
Keyword(s):  
Metabolic Regulation ◽  
Developmental Toxicity ◽  
Meat Products ◽  
Complex Interaction ◽  
Hatching Rate ◽  
Zebrafish Embryos ◽  
Reciprocal Effects ◽  
Combined Exposure ◽  
Simultaneous Exposure ◽  
Developmental Parameters

Carbendazim (CAR) and enrofloxacin (ENF) are frequently detected in fruits and meat products, respectively. Since most people consume fruits, vegetables, and meat products, combined exposure is possible, necessitating further evaluation of toxic interactions. In this study, the developmental toxicity of separate and combined exposure was examined in zebrafish embryos. Carbendazim exposure at 0.79 mg/L and above significantly affected developmental parameters, while enrofloxacin alone had no substantial effects on these developmental parameters within the selected concentration range (0.10–0.40 mg/L). Surprisingly, ENF antagonized the CAR-evoked reduction in the 48 hpf (hours post-fertilization) hatching rate and the increases in the 96 hpf malformation and lethality rates. The results revealed that the antagonism might be associated with reciprocal effects of these compounds on metabolism-related genes, such as cyp7a1 and apoa1a. These results reveal a complex interaction between ENF and CAR on metabolic regulation during development and highlight the importance of combined assessment for agents with the potential for simultaneous exposure.

scholarly journals Comparative Toxicity Assessment of Kratom Decoction, Mitragynine and Speciociliatine Versus Morphine on Zebrafish (Danio rerio) Embryos

2021 ◽  
Vol 12 ◽  
Author(s):  
Thenmoly Damodaran ◽  
Nelson Jeng-Yeou Chear ◽  
Vikneswaran Murugaiyah ◽  
Mohd Nizam Mordi ◽  
Surash Ramanathan
Keyword(s):  
Therapeutic Potential ◽  
Developmental Toxicity ◽  
Toxicity Assessment ◽  
Spinal Curvature ◽  
Hatching Rate ◽  
Morphological Development ◽  
Zebrafish Embryos ◽  
Dependent Manner ◽  
Zebrafish Model ◽  
Concentration Dependent Manner

Background: Kratom (Mitragyna speciosa Korth), a popular opioid-like plant holds its therapeutic potential in pain management and opioid dependence. However, there are growing concerns about the safety or potential toxicity risk of kratom after prolonged use.Aim of the study: The study aimed to assess the possible toxic effects of kratom decoction and its major alkaloids, mitragynine, and speciociliatine in comparison to morphine in an embryonic zebrafish model.Methods: The zebrafish embryos were exposed to kratom decoction (1,000–62.5 μg/ml), mitragynine, speciociliatine, and morphine (100–3.125 μg/ml) for 96 h post-fertilization (hpf). The toxicity parameters, namely mortality, hatching rate, heart rate, and morphological malformations were examined at 24, 48, 72, and 96 hpf, respectively.Results: Kratom decoction at a concentration range of ≥500 μg/ml caused 100% mortality of zebrafish embryos and decreased the hatching rate in a concentration-dependent manner. Meanwhile, mitragynine and speciociliatine exposure resulted in 100% mortality of zebrafish embryos at 100 μg/ml. Both alkaloids caused significant alterations in the morphological development of zebrafish embryos including hatching inhibition and spinal curvature (scoliosis) at the highest concentration. While exposure to morphine induced significant morphological malformations such as pericardial oedema, spinal curvature (lordosis), and yolk edema in zebrafish embryos.Conclusion: Our findings provide evidence for embryonic developmental toxicity of kratom decoction and its alkaloids both mitragynine and speciociliatine at the highest concentration, hence suggesting that kratom consumption may have potential teratogenicity risk during pregnancy and thereby warrants further investigations.

scholarly journals Roots and stems of Kadsura coccinea extract induced developmental toxicity in zebrafish embryos/larvae through apoptosis and oxidative stress

2020 ◽  
Vol 58 (1) ◽  
pp. 1294-1301
Author(s):  
Zhongshang Xia ◽  
Erwei Hao ◽  
Zhangmei Chen ◽  
Mingzhe Zhang ◽  
Yanting Wei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Developmental Toxicity ◽  
Zebrafish Embryos ◽  
Kadsura Coccinea ◽  
And Oxidative Stress

Isoliquiritigenin triggers developmental toxicity and oxidative stress–mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway

Chemosphere ◽  
2020 ◽  
Vol 246 ◽  
pp. 125727 ◽  
Author(s):  
Zhenzhen Song ◽  
Yun Zhang ◽  
Huazheng Zhang ◽  
R. Samuel Rajendran ◽  
Rongchun Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Developmental Toxicity ◽  
Zebrafish Embryos ◽  
And Oxidative Stress

Developmental toxicity evaluation of ten disinfection by-products on Zebrafish embryos

2012 ◽  
Vol 34 (2) ◽  
pp. 169
Author(s):  
Teixidó Elisabet ◽  
Gómez-Catalán Jesús ◽  
Piqué Ester ◽  
Boix Núria ◽  
M. Llobet Joan
Keyword(s):  
Developmental Toxicity ◽  
Zebrafish Embryos ◽  
Toxicity Evaluation ◽  
By Products

Interactions of Caffeine and Restraint Stress During Pregnancy in Mice

2002 ◽  
Vol 227 (9) ◽  
pp. 779-785 ◽  
Author(s):  
M. Luisa Albina ◽  
M. Teresa Colomina ◽  
Domenec J. Sanchez ◽  
Margarita Torrente ◽  
Jose L. Domingo
Keyword(s):  
Restraint Stress ◽  
Developmental Toxicity ◽  
Experimental Period ◽  
Toxic Effects ◽  
Cesarean Sections ◽  
Combined Exposure ◽  
Control Groups ◽  
Fetal Toxicity ◽  
Skeletal Malformations ◽  
Developmental Effects

The maternal and developmental toxicity of combined exposure to restraint stress and caffeine was assessed in mice. On gestational Days 0–18, three groups of plug-positive females (n = 13–15) were given by gavage caffeine at 30, 60, and 120 mg/kg/day. Three additional groups received the same caffeine doses and were restrained for 2 hr/day. Control groups included restrained and unrestrained plug-positive mice not exposed to caffeine. All animals in the group concurrently exposed to 120 mg/kg/day of caffeine and restraint died during the experimental period. In the remaining groups, cesarean sections were performed on Day 18 of gestation, and the fetuses were weighed and examined for external, internal, and skeletal malformations and variations. Although maternal and embryo/fetal toxicity were observed at all caffeine doses, the adverse maternal and developmental effects were significantly enhanced in the groups concurrently exposed to caffeine and restraint. It was especially remarkable at 60 and 120 mg/kg/day. The results of this study suggest that maternal and developmental toxic effects might occur if high amounts of caffeine were consumed by women under a notable stress during pregnancy.

scholarly journals Developmental toxicity and brain aromatase induction by high genistein concentrations in zebrafish embryos

2009 ◽  
Vol 19 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Dong-Jae Kim ◽  
Seung-Hyeok Seok ◽  
Min-Won Baek ◽  
Hui-Young Lee ◽  
Yi-Rang Na ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Zebrafish Embryos ◽  
Brain Aromatase
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