scholarly journals Clinical Characteristics, Treatments and Outcomes of 18 Lung Transplant Recipients with COVID-19

2021 ◽  
Vol 2 (2) ◽  
pp. 229-245
Author(s):  
René Hage ◽  
Carolin Steinack ◽  
Fiorenza Gautschi ◽  
Susan Pfister ◽  
Ilhan Inci ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Clinical Laboratory ◽  
Invasive Mechanical Ventilation ◽  
Case Series ◽  
Outcome Data ◽  
Transplant Recipients ◽  
Retrospective Case ◽  
Laboratory Findings ◽  
Case Series Study ◽  
Lung Transplant Recipients

We report clinical features, treatments and outcomes in 18 lung transplant recipients with laboratory confirmed SARS-CoV-2 infection. We performed a single center, retrospective case series study of lung transplant recipients, who tested positive for SARS-CoV-2 between 1 February 2020 and 1 March 2021. Clinical, laboratory and radiology findingswere obtained. Treatment regimens and patient outcome data were obtained by reviewing the electronic medical record. Mean age was 49.9 (22–68) years, and twelve (67%) patients were male. The most common symptoms were fever (n = 9, 50%), nausea/vomiting (n = 7, 39%), cough (n = 6, 33%), dyspnea (n = 6, 33%) and fatigue (n = 6, 33%). Headache was reported by five patients (28%). The most notable laboratory findings were elevated levels of C-reactive protein (CRP) and lactate dehydrogenase (LDH). Computed Tomography (CT) of the chest was performed in all hospitalized patients (n = 11, 7%), and showed ground-glass opacities (GGO) in 11 patients (100%), of whom nine (82%) had GGO combined with pulmonary consolidations. Six (33%) patients received remdesivir, five (28%) intravenous dexamethasone either alone or in combination with remdesivir, and 15 (83%) were treated with broad spectrum antibiotics including co-amoxicillin, tazobactam-piperacillin and meropenem. Four (22%) patients were transferred to the intensive care unit, two patients (11%) required invasive mechanical ventilation who could not be successfully extubated and died. Eighty-nine percent of our patients survived COVID-19 and were cured. Two patients with severe COVID-19 did not survive.

scholarly journals Clinical Features of Patients with Probable 2019 Novel Coronavirus Infected Pneumonia in Rasht, Iran: A Retrospective Case Series

2020 ◽  
Vol 8 (T1) ◽  
pp. 16-22
Author(s):  
Samad Karkhah ◽  
Mohammad Javad Ghazanfari ◽  
Amir Shamshirian ◽  
Latif Panahi ◽  
Meysam Molai ◽  
...  
Keyword(s):  
Clinical Features ◽  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Case Series ◽  
Symptomatic Treatment ◽  
Retrospective Case ◽  
Laboratory Findings ◽  
Retrospective Case Series ◽  
Case Series Study ◽  
Novel Coronavirus

BACKGROUND: Coronavirus disease-19 (COVID-19) is the first pandemic infectious disease caused by a novel coronavirus. Viral pneumonia is a severe complication of COVID-19. AIM: Due to the high prevalence of this disease globally, especially in Iran, the aim of this study was to determine the clinical features of seven patients with probable COVID-19 infected pneumonia in Rasht, North Iran. MATERIALS AND METHODS: In this retrospective case series study, we described the clinical, laboratory, and radiological features of seven patients with probable COVID-19 infected pneumonia at Razi Hospital, Rasht, north of Iran, from February 27 to March 16, 2020. RESULTS: In this study, the most common clinical symptoms during hospitalization in patients with COVID-19 were poor appetite (seven cases), dehydration (seven cases), cough (six cases), dyspnea (six cases), fatigue (six cases), fever above 38°C (five cases), myalgia (five cases), Chills (five cases), feeling fever (five cases), sore throat (five cases), and nausea (five cases), respectively. The average body temperature in these patients was 39.32°C. In laboratory findings, erythrocyte sedimentation rate was elevated in three patients. Contrary to most of the evidence, C-reactive protein was not elevated in five patients. All patients received antibiotic and antiviral medications and received symptomatic treatment. Finally, four patients responded to the treatments and were discharged from the hospital; two patients were still hospitalized and only one patient died. CONCLUSION: Patients with COVID-19 associated pneumonia can be treated by evaluating and implementing appropriate therapeutic management. However, at the moment the disease progression for patients with COVID-19 cannot be accurately predicted.

scholarly journals COVID-19 Disease in Lung Transplant Recipients: A Case Series

2021 ◽  
Vol 40 (4) ◽  
pp. S314
Author(s):  
L.L. Seijo ◽  
A. Perez ◽  
N. Thakur ◽  
A. Venado ◽  
L.E. Leard ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Case Series ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

scholarly journals COVID‐19 in lung transplant recipients: A case series from Milan, Italy

2020 ◽  
Vol 22 (6) ◽  
Author(s):  
Letizia Corinna Morlacchi ◽  
Valeria Rossetti ◽  
Lorenzo Gigli ◽  
Francesco Amati ◽  
Lorenzo Rosso ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Case Series ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

Hepatitis E Virus Infection in Lung Transplant Recipients: A Case Series

2019 ◽  
Vol 51 (2) ◽  
pp. 376-379 ◽  
Author(s):  
G.P.L. Ambrocio ◽  
S. Aguado ◽  
J. Carrillo ◽  
R. Laporta ◽  
M. Lazaro-Carrasco ◽  
...  
Keyword(s):  
Virus Infection ◽  
Lung Transplant ◽  
Hepatitis E Virus ◽  
Case Series ◽  
Hepatitis E ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

Carbapenem-resistantKlebsiella pneumoniaein lung transplant recipients: A case series

2015 ◽  
Author(s):  
Priscila Cilene León Bueno Camargo ◽  
Silvia Vidal Campos ◽  
Felipe Xavier Melo ◽  
Ricardo Henrique de Oliveira Braga Teixeira ◽  
Paulo Manuel Pêgo-Fernandes
Keyword(s):  
Lung Transplant ◽  
Case Series ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

Experience with leflunomide as treatment and as secondary prophylaxis for cytomegalovirus infection in lung transplant recipients: A case series and review of the literature

2017 ◽  
Vol 32 (2) ◽  
pp. e13176 ◽  
Author(s):  
Jose Tiago Silva ◽  
Virginia Pérez-González ◽  
Francisco Lopez-Medrano ◽  
Rodrigo Alonso-Moralejo ◽  
Mario Fernández-Ruiz ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Lung Transplant ◽  
Case Series ◽  
Secondary Prophylaxis ◽  
Transplant Recipients ◽  
Review Of The Literature ◽  
Lung Transplant Recipients

scholarly journals Squamous cell carcinoma of the skin and voriconazole therapy in lung transplant recipients: a case series

2017 ◽  
Vol 47 (3) ◽  
pp. 228-235 ◽  
Author(s):  
Chin Fen Neoh ◽  
Gregory I. Snell ◽  
Bronwyn Levvey ◽  
Catherine Orla Morrissey ◽  
Monica A. Slavin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lung Transplant ◽  
Case Series ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

scholarly journals Oral health of patients suffering from end-stage solid organ insufficiency prior to solid organ re-transplantation: a retrospective case series study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tobias Moest ◽  
Rainer Lutz ◽  
Arne Eric Jahn ◽  
Katharina Heller ◽  
Mario Schiffer ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Surgical Intervention ◽  
Case Series ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Retrospective Case ◽  
Treatment Need ◽  
Case Series Study ◽  
Series Study ◽  
Radiological Examinations

Abstract Background The oral health of organ transplanted patients before organ re-transplantation is largely unknown. This retrospective clinical study evaluates the necessity for intraoral surgical intervention and/or conservative treatment in candidates awaiting organ re-transplantation, both for graft failure and for reasons of another upcoming solid organ transplantation (renal or non-renal). Methods From January 2015 to March 2020 n = 19 transplant recipients in evaluation on the waiting list for solid organ re-transplantation could be included in the retrospective case series study. Using clinical and radiological examinations, necessity for oral surgical or conservative dental treatment was evaluated. On the basis of anamnesis data, current kidney function, renal replacement treatment (RRT), and medication, a risk profile for several patient subgroups was created. Results The clinical and radiological examinations showed a conservative and/or surgical treatment need in n = 13 cases (68.42%). In n = 7 cases (36.84%) surgical intervention was recommended due to residual root remnants (n = 5), unclear mucosal changes (n = 1), and periimplantitis (n = 1). In n = 16 recipients (84.2%) RRT (n = 15 hemodialysis; n = 1 peritoneal dialysis) had been performed. N = 14 recipients (73.68%) received immunosuppressants. In n = 1 patient (5.3%) displayed intraoral and n = 4 patients (21.1%) extraoral neoplasms due to drug-induced immunosuppression. Conclusions Solid organ transplant recipients with renal failure present a complex treatment profile due to a double burden of uremia plus immunosuppressants. In cases of surgical treatment need a hospitalized setting is recommended, where potentially necessary follow-up care and close cooperation with disciplines of internal medicine is possible in order to avoid surgical and/or internal complications.

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