scholarly journals Achieving Health Security and Threat Reduction through Sharing Sequence Data

2019 ◽  
Vol 4 (2) ◽  
pp. 78 ◽  
Author(s):  
Kenneth Yeh ◽  
Jeanne Fair ◽  
Helen Cui ◽  
Carl Newman ◽  
Gavin Braunstein ◽  
...  

With the rapid development and broad applications of next-generation sequencing platforms and bioinformatic analytical tools, genomics has become a popular area for biosurveillance and international scientific collaboration. Governments from countries including the United States (US), Canada, Germany, and the United Kingdom have leveraged these advancements to support international cooperative programs that aim to reduce biological threats and build scientific capacity worldwide. A recent conference panel addressed the impacts of the enhancement of genomic sequencing capabilities through three major US bioengagement programs on international scientific engagement and biosecurity risk reduction. The panel contrasted the risks and benefits of supporting the enhancement of genomic sequencing capabilities through international scientific engagement to achieve biological threat reduction and global health security. The lower costs and new bioinformatic tools available have led to the greater application of sequencing to biosurveillance. Strengthening sequencing capabilities globally for the diagnosis and detection of infectious diseases through mutual collaborations has a high return on investment for increasing global health security. International collaborations based on genomics and shared sequence data can build and leverage scientific networks and improve the timeliness and accuracy of disease surveillance reporting needed to identify and mitigate infectious disease outbreaks and comply with international norms. Further efforts to promote scientific transparency within international collaboration will improve trust, reduce threats, and promote global health security.

2019 ◽  
Author(s):  
Tim Eckmanns ◽  
Henning Füller ◽  
Stephen L. Roberts

Contemporary infectious disease surveillance systems aim to employ the speed and scope of big data in an attempt to provide global health security. Both shifts - the perception of health problems through the framework of global health security and the corresponding technological approaches – imply epistemological changes, methodological ambivalences as well as manifold societal effects. Bringing current findings from social sciences and public health praxis into a dialogue, this conversation style contribution points out several broader implications of changing disease surveillance. The conversation covers epidemiological issues such as the shift from expert knowledge to algorithmic knowledge, the securitization of global health, and the construction of new kinds of threats. Those developments are detailed and discussed in their impacts for health provision in a broader sense.


2019 ◽  
Vol 47 (3) ◽  
pp. 412-426 ◽  
Author(s):  
Tsion Berhane Ghedamu ◽  
Benjamin Mason Meier

Immunization plays a crucial role in global health security, preventing public health emergencies of international concern and protecting individuals from infectious disease outbreaks, yet these critical public health benefits are dependent on immunization law. Where public health law has become central to preventing, detecting, and responding to infectious disease, public health law reform is seen as necessary to implement the Global Health Security Agenda (GHSA). This article examines national immunization laws as a basis to implement the GHSA and promote the public's health, analyzing the scope and content of these laws to prevent infectious disease across Sub-Saharan Africa. Undertaking policy surveillance of national immunization laws in 20 Sub-Saharan African countries, this study: (1) developed a legal framework to map the legal attributes relevant to immunization; (2) created an assessment tool to determine the presence of these attributes under national immunization law; and (3) applied this assessment tool to code national legal landscapes. An analysis of these coded laws highlights legal attributes that govern vaccine requirements, supply chains, vaccine administration standards, and medicines quality and manufacturer liability. Based upon this international policy surveillance, it will be crucial to undertake legal epidemiology research across countries, examining the influence of immunization law on vaccination rates and disease outbreaks.


2018 ◽  
Vol 134 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Rebecca E. Bunnell ◽  
Zara Ahmed ◽  
Megan Ramsden ◽  
Karina Rapposelli ◽  
Madison Walter-Garcia ◽  
...  

2002 ◽  
Vol 6 (50) ◽  
Author(s):  
E Hoile

Preparedness and response to the threats of smallpox, chemical release and pandemic influenza were discussed at the third meeting of the Global Health Security Initiative on 6 December 2002 in Mexico City. The meeting was attended by health ministers and secretaries from the G7+ countries (Canada, France, Germany, Italy, Japan, the United Kingdom, and the United States (US), plus Mexico), and the European Commissioner for Health and Consumer Protection (1). The first meeting, which saw the launch of the initiative, was held in Ottawa in November 2001, and a second meeting was held in London, in March 2002 (2).


2002 ◽  
Vol 6 (12) ◽  
Author(s):  
R Harling

Health ministers met in London on 14 March to make progress with the coordinated international initiative to improve global health security (http://tap.ccta.gov.uk/doh/intpress.nsf/page/2002-0132?OpenDocument). The aim is to better prepare for and respond to acts of chemical, biological, and radionuclear terrorism. Ministers, secretaries, and senior officials from the European Union, Germany, France, the United Kingdom, Italy, the United States, Canada, Mexico, and Japan were involved.


Author(s):  
Heath J Benton

This chapter traces the normative challenges underlying the legal framework for health security. Today’s challenges can be understood as the result of three successive stages of development in global health law. First was the securitization of global public health, whereby a diffuse group of international and national health officials, outside experts, and advocates worked to redefine infectious disease outbreaks as a critical national and international security issue. Secondly, this concept of global health security was inscribed in law through the 2005 revisions to the International Health Regulations, which adopted a governance framework that appeared to be deliberately modelled on domestic emergency powers regimes. Thirdly, this development, rather than settling the World Health Organization’s (WHO) authority in health emergencies, has in turn set off waves of contestation that concern the nature of global health security and how it should be institutionalized. This includes contestation about the internal governance arrangements within the WHO; external conflicts of jurisdiction between the WHO and other institutions; and disagreement about the normative orientation and scope of the WHO’s emergency power.


2015 ◽  
Vol 43 (S1) ◽  
pp. 103-106
Author(s):  
Brent Davidson ◽  
Susan Sherman ◽  
Leila Barraza ◽  
Maria Julia Marinissen

In an increasingly interconnected global community, severe disasters or disease outbreaks in one country or region may rapidly impact global health security. As seen during the responses to the earthquakes in Haiti and Japan, Typhoon Haiyan in the Philippines, and the current Ebola outbreak in West Africa, local response capacities can be rapidly overwhelmed and international assistance may be necessary to support the affected region to respond and recover and to protect other countries from the spread of disease. For example, President Obama stated on September 16, 2014, that “if the [Ebola] outbreak is not stopped now, we could be looking at hundreds of thousands of people infected, with profound political and economic and security implications for all of us…. [T]his…is not just a threat to regional security — it’s a potential threat to global security if these countries break down…. And that’s why…I directed my team to make this a national security priority.”


2011 ◽  
Vol 59 (4) ◽  
pp. 797-812 ◽  
Author(s):  
Thomas Abraham

The period beginning in 2004 saw an extraordinary spurt in attention paid to avian and pandemic influenza in the United States and at the global level. A disease that for decades had languished in the ‘dull but worthy’ category of infectious diseases was elevated to a risk to global health security. The securitisation of influenza was not unproblematic. The influenza pandemic of 2009 turned out to be far milder than anticipated, and much of the scientific basis on which planning had proceeded and resources had been mobilised turned out to be wrong. Developing countries with other disease priorities were urged to pour resources into pandemic planning exercises and change poultry-raising practices. The article argues that for an issue to be securitised as a global health threat, it is essential that the United States takes the lead role (or at the very least supports efforts by other leading powers). It uses the Copenhagen School's analysis to examine how avian and pandemic influenza was securitised in the United States, and then uses the concept of framing to examine why this disease was securitised by looking at the prior existence of an issue culture or discourse around emerging infectious diseases, which gained salience after the 2011 anthrax attacks. It finally looks at the impact of securitisation on countries with different priorities.


2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Eileen Reynolds ◽  
Boubacar Dialio ◽  
Pia Macdonald

ObjectiveThe objective is to share the progress and challenges in the implementation of the District Health Information Software Version 2 (DHIS 2) as an electronic disease surveillance system platform in Guinea, West Africa, to inform Global Health Security Agenda efforts to strengthen real-time surveillance in low-resource settings.IntroductionThe West Africa Ebola outbreak of 2014-2016 demonstrated the importance of strong disease surveillance systems and the severe consequences of weak capacity to detect and respond to cases quickly. Challenges in the transmission and management of surveillance data were one factor that contributed to the delay in detecting and confirming the Ebola outbreak1. To help address this challenge, we have collaborated with the U.S. Centers for Disease Control and Prevention (CDC), the Ministry of Health (MOH) in Guinea, the World Health Organization and various partners to strengthen the disease surveillance system through the implementation of an electronic reporting system using an open source software tool, the District Health Information Software Version 2 (DHIS 2). These efforts are part of the Global Health Security Agenda objective to strengthen real-time surveillance2. This online system enables prefecture health offices to enter aggregate weekly disease reports from health facilities and for that information to be immediately accessible to designated staff at prefecture, regional and national levels.Incorporating DHIS 2 includes several advantages for the surveillance system. For one, the data is available in real time and can be analyzed quickly using built-in data analysis tools within DHIS 2 or exported to other analysis tools. In contrast, the existing system of reporting using Excel spreadsheets requires the MOH to manually compile spreadsheets from all the 38 prefectures to have case counts for the national level.For the individual case notification system, DHIS 2 enables a similar accessibility of information that does not exist with the current paper-based reporting system. Once a case notification form is completed in DHIS 2, the case-patient information is immediately accessible to the laboratories receiving specimens and conducting testing for case confirmation. The system is designed so that laboratories enter the date and time that a specimen is received, and any test results. The results are then immediately accessible to the reporting district and to the stakeholders involved including the National Health Security Agency and the Expanded Program on Vaccination. In addition, DHIS 2 can generate email and short message service (SMS) messages to notify concerned parties at critical junctures in the process, for example, when a laboratory result is available for a given case.MethodsThis presentation is based on review of project experience and documentation for a Global Health Security project in Guinea from 2015-2018. In addition, this includes a 2017 evaluation of the DHIS 2 pilot phase in two regions each having five prefectures.ResultsThe use of DHIS 2 for aggregate and individual case reports for disease surveillance was piloted in two regions in Guinea in 2017 for a period of six months. An evaluation of the pilot phase indicated strong capacity at the Prefecture Level to use the system for weekly aggregate disease reporting as evidenced by the high weekly reporting rates as well as an assessment of users’ capacities. Challenges observed during the pilot phase included weak follow-up and ownership by the national level MOH, weak adherence by the laboratories to enter data on the receipt and test results of laboratory samples, and individual case reports not filed in all cases. In addition, the lack of uniformity of common data elements on the forms across different diseases made analysis and data quality more challenging.Following the evaluation of the pilot phase the MOH directed that the system should be used for aggregate weekly reporting, however that the individual case reporting in DHIS 2 should wait until improvements could be made in the case report forms. Prefectures have used DHIS 2 for weekly aggregate disease reporting starting in January 2018. In addition, the MOH plans to implement electronic individual case reporting in DHIS 2 starting in October 2018.ConclusionsProgress to date includes nationwide use of DHIS 2 by all prefectures for the submission of weekly aggregate case reports. In addition, the new case report forms have been configured in DHIS 2 and a training of trainers has been conducted at the national level to begin the process of implementing the electronic case reporting nationwide.Challenges include the continuation of parallel weekly disease reporting in Excel for an extended period after adoption of DHIS 2 resulting in lower timeliness of weekly reports in DHIS 2 in some prefectures, weak use of the system for data analysis, building capacity within the Ministry of Health to maintain the system without outside assistance, sufficient resources to pay for internet access and power back-up (such as solar power) to enable the health offices to effectively use the system, weak data privacy and security procedures, and the need to strengthen management of the national DHIS 2 server.References1. Ministère de la Santé-République de Guinée, Direction Nationale de la Prevention et Santé Communautaire, Division Prevention et Lutte Contre la Maladie. Plan de Renforcement de la Surveillance des Maladies à Potentiel Epidémique en Guinée (2015-2017), August 2015.2. Global Health Security Agenda. Real-Time Surveillance Action Package: GHSA Action Package Detect 2 & 3. [cited 2018 Oct 3]. Available from: https://www.ghsagenda.org/packages/d2-3-real-time-surveillance 


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