scholarly journals Retrospective Analysis of Six Years of Acute Flaccid Paralysis Surveillance and Polio Vaccine Coverage Reported by Italy, Serbia, Bosnia and Herzegovina, Montenegro, Bulgaria, Kosovo, Albania, North Macedonia, Malta, and Greece

Vaccines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 44
Author(s):  
Stefano Fontana ◽  
Gabriele Buttinelli ◽  
Stefano Fiore ◽  
Concetta Amato ◽  
Marco Pataracchia ◽  
...  
Keyword(s):  
Acute Flaccid Paralysis ◽  
Vaccine Coverage ◽  
Laboratory Data ◽  
Vaccine Uptake ◽  
Flaccid Paralysis ◽  
Data Management System ◽  
Reference Laboratory ◽  
Polio Vaccine ◽  
Acute Flaccid Paralysis Surveillance ◽  
Afp Surveillance

Here we analyzed six years of acute flaccid paralysis (AFP) surveillance, from 2015 to 2020, of 10 countries linked to the WHO Regional Reference Laboratory, at the Istituto Superiore di Sanità, Italy. The analysis also comprises the polio vaccine coverage available (2015–2019) and enterovirus (EV) identification and typing data. Centralized Information System for Infectious Diseases and Laboratory Data Management System databases were used to obtain data on AFP indicators and laboratory performance and countries’ vaccine coverage from 2015 to 2019. EV isolation, identification, and typing were performed by each country according to WHO protocols. Overall, a general AFP underreporting was observed. Non-Polio Enterovirus (NPEV) typing showed a high heterogeneity: over the years, several genotypes of coxsackievirus and echovirus have been identified. The polio vaccine coverage, for the data available, differs among countries. This evaluation allows for the collection, for the first time, of data from the countries of the Balkan area regarding AFP surveillance and polio vaccine coverage. The need, for some countries, to enhance the surveillance systems and to promote the polio vaccine uptake, in order to maintain the polio-free status, is evident.

scholarly journals Impact of the protracted war on performance of Acute Flaccid Paralysis Surveillance System Indicators, Yemen: 2014-2017 (Preprint)

2021 ◽  
Author(s):  
Riham Al-Dubaiee ◽  
Mutaher AL Qassimi ◽  
Ahmed Al-Dar ◽  
Abdulwahed Al Serouri ◽  
Yousef Khader
Keyword(s):  
Surveillance System ◽  
Acute Flaccid Paralysis ◽  
National Level ◽  
Good Condition ◽  
Flaccid Paralysis ◽  
Reference Laboratory ◽  
Acute Flaccid Paralysis Surveillance ◽  
Afp Surveillance ◽  
Stool Specimens ◽  
The Impact

BACKGROUND Highly sensitive acute flaccid paralysis surveillance (AFP), which include immediate case investigation, and specimen collection are critical for reaching polio global eradication. In Yemen, the Acute Flaccid Paralysis Surveillance System (AFPSS) was launched in 1998 to achieve the polio eradication target. Although Yemen was certified as polio free country in 2009, the protracted war since 2015 put the country at risk for polio re-emergence OBJECTIVE to evaluate the performance of the Yemen AFPSS at both national and governorate levels and to assess the impact of the ongoing war on the performance METHODS Retrospective descriptive analysis was conducted on Yemen secondary AFP surveillance data for the years 2014 (before the war) and 2015-2017 (during the war). Data consisting of all children <15years reported as AFP. AFP surveillance performance was evaluated using WHO-specified AFP surveillance indicators RESULTS At the national level, all indicators were met before and after the war except for the “Lab results received ≤ 28 days” that was unmet since the war erupted. Furthermore, the “Stool specimens arriving at central level ≤3 days” was unmet after the war but only in 2017. At the governorate level, although the “Adequacy” and "Stool specimens arriving at laboratory in good condition” indicators were met before the war in all governorates, the first indicator was unmet in 9 (41%) governorates since the war erupted and the second was unmet in 9 governorates (41%) but only in 2017 CONCLUSIONS Findings showed that some of the AFP indicators was negatively impacted by eruption of the war due to closure of the Sana'a capital airport and postponement of samples during shipment to the reference laboratory under poor storage condition. To ensure rapid detection of any polio cases, improving specimens’ collection, storage, and transportation together with proper and timely specimens' shipment to the reference laboratory should be considered

Detection of non-polio and polio enteroviruses in Acute Flaccid Paralysis surveillance in Turkey

2021 ◽  
Author(s):  
Gulay Korukluoglu ◽  
Umit Ozdemirer ◽  
Fatma Bayrakdar ◽  
Zehra Unal ◽  
Yasemin Cosgun ◽  
...  
Keyword(s):  
Acute Flaccid Paralysis ◽  
Flaccid Paralysis ◽  
Sequencing Analysis ◽  
National Data ◽  
Polio Virus ◽  
Vaccination Rates ◽  
Acute Flaccid Paralysis Surveillance ◽  
Polio Vaccination ◽  
Afp Surveillance ◽  
Comprehensive Study

AbstractPoliomyelitis was a disease feared worldwide, striking suddenly and paralysing mainly children for life. Monitoring of suspected cases of poliomyelitis is carried out with Acute Flaccid Paralysis (AFP) surveillance in Turkey. This study examines national data of AFP surveillance and the epidemiology of enteroviruses (EV) in Turkey from 2000 to 2019 and gives an overview of the detected serotypes of EVs. A total of 13,640 samples collected from patients with 5216 AFP pre-diagnosed cases (2 samples from each patient) and 3,208 contacts, during a 20-year period (2000–2019) were investigated. All isolated polioviruses were tested for their wild or vaccine origin according to the WHO recommended protocol by PCR and sequencing analysis were performed. Enterovirus positivity was detected in a total of 915 cases, which were identified as 204 Sabin-like polio virus (SLPV) and 711 non-polio enterovirus (NPEV). Of the 204 SLPV, 141 (69.1%) AFP were detected in patients and 63 (30.9%) were detected in samples taken from their contacts. Of the 711 NPEVs, 516 (72.5%) were from AFP cases and 195 (27.5%) were detected in samples taken from their contacts. It is concluded that the reason for the higher detection rate of NPEV in samples from AFP pre-diagnosed cases is attributed to the polio vaccination rates reaching 97% between 2008 and 2019 in Turkey. The most frequently detected NPEV serotypes were Coxackie A24, B3, and Echo 30. This retrospective study is the first comprehensive study in Turkey to evaluate the results of the AFP surveillance in the last 20 years.

scholarly journals Enterovirus D68 Subclade B3 Circulation in Senegal, 2016: Detection from Influenza-like Illness and Acute Flaccid Paralysis Surveillance

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Amary Fall ◽  
Ndack Ndiaye ◽  
Mamadou Malado Jallow ◽  
Mamadou Aliou Barry ◽  
Cheikh Saad Bou Touré ◽  
...  
Keyword(s):  
Active Surveillance ◽  
Acute Flaccid Paralysis ◽  
Flaccid Paralysis ◽  
Influenza Like Illness ◽  
Acute Flaccid Paralysis Surveillance ◽  
Afp Surveillance ◽  
Enterovirus D68 ◽  
Low Levels ◽  
Respiratory Specimens ◽  
Children Under 5

Abstract Following the 2014 outbreak, active surveillance of the EV-D68 has been implemented in many countries worldwide. Despite subsequent EV-D68 outbreaks (2014 and 2016) reported in many areas, EV-D68 circulation remains largely unexplored in Africa except in Senegal, where low levels of EV-D68 circulation were first noted during the 2014 outbreak. Here we investigate subsequent epidemiology of EV-D68 in Senegal from June to September 2016 by screening respiratory specimens from ILI and stool from AFP surveillance. EV-D68 was detected in 7.4% (44/596) of patients; 40 with ILI and 4 with AFP. EV-D68 detection was significantly more common in children under 5 years (56.8%, p = 0.016). All EV-D68 strains detected belonged to the newly defined subclade B3. This study provides the first evidence of EV-D68 B3 subclade circulation in Africa from patients with ILI and AFP during a 2016 outbreak in Senegal. Enhanced surveillance of EV-D68 is needed to better understand the epidemiology of EV-D68 in Africa.

scholarly journals Acute Flaccid Paralysis surveillance in Polio Eradication and Beyond: Learning from Bangladesh

2021 ◽  
Author(s):  
Humayra Binte Anwar ◽  
Yameen Mazumder ◽  
Sanjana Nujhat ◽  
Bushra Zarin Islam ◽  
Anna Kalbarczyk ◽  
...  
Keyword(s):  
Surveillance System ◽  
Disease Surveillance ◽  
Technical Assistance ◽  
Acute Flaccid Paralysis ◽  
Grey Literature ◽  
Polio Eradication ◽  
Flaccid Paralysis ◽  
Depth Information ◽  
Acute Flaccid Paralysis Surveillance ◽  
Afp Surveillance

Abstract IntroductionGlobal Polio Eradication Initiative, GPEI led by the World Health Organization (WHO), helped to develop standard acute flaccid paralysis surveillance (AFP) system worldwide, including Bangladesh, which comprises infrastructure, knowledge, expertise, funding, technical assistance, and trained personnel. AFP surveillance can complement any disease surveillance systems, and many countries are now utilizing these polio surveillance assets for monitoring other vaccine-preventable diseases. This paper outlines how AFP surveillance has evolved in Bangladesh over time, its success and challenging factors, and its potential to accomplish other health goals.MethodologyThis mixed-method study includes a grey literature review, a survey for quantitative and qualitative information on barriers and facilitators, and Key Informant Interviews (KIIs) to gather relevant in-depth information on AFP surveillance in Bangladesh. Grey literature was collected online and paper documentation from different stakeholders. Online and in-person surveys were conducted in six divisions of Bangladesh, including Dhaka, Rajshahi, Rangpur, Chittagong, Sylhet, and Khulna, to map tacit knowledge ideas, approaches, and experiences. KIIs were conducted at global, national, and sub-national levels. Data were then combined on focused emerging themes, including history, challenges, and successes of the AFP surveillance system in Bangladesh.ResultsAFP surveillance in Bangladesh was first introduced in 1990 at the district and Upazila level major hospitals. High population growth, low performance, hard-to-reach areas, and groups of people residing in risky zones were major challenges to implementing this surveillance system. Surveillance was gradually enriched by establishing certification standards and community-based AFP surveillance and improved Surveillance Immunization Medical Officer (SIMO) network activities, laboratory activities, and proper monitoring and evaluation. In Bangladesh, a national disease surveillance system and a laboratory are now being used for multiple diseases, including polio, measles, Japanese Encephalitis, Neonatal Tetanus etc.ConclusionIn Bangladesh, it is evident that the AFP surveillance system is supporting the health system more broadly by building knowledge, experience, and assets and forming a strong platform for other health programs. In addition, its strengths can be leveraged for combating new and emerging diseases like COVID-19. However, the sustainability of the AFP surveillance in Bangladesh still needs collaborative support from partners, mainly technical assistance.

scholarly journals ACUTE FLACCID PARALYSIS SURVEILLANCE SYSTEM: CURRENT STATUS IN AZAD JAMMU & KASHMIR- 2018

2019 ◽  
Vol 9 (2) ◽  
pp. 54-56
Author(s):  
Syed Nadeem-ur-Rehman ◽  
Uzma Hafeez ◽  
Mumtaz Ahmad Khan ◽  
Masood Ahmad Bukhari
Keyword(s):  
Surveillance System ◽  
Disease Surveillance ◽  
Acute Flaccid Paralysis ◽  
Case Definition ◽  
Flaccid Paralysis ◽  
Current Status ◽  
Adjacent Area ◽  
Surveillance Systems ◽  
Acute Flaccid Paralysis Surveillance ◽  
Afp Surveillance

Background: The State of Azad Jammu & Kashmir (AJ&K) is polio free since October 2000.The objectives of our study is to review of existing Acute Flaccid Paralysis Surveillance System in Azad Jammu &Kashmir, identify the strong & weak points of the existing system and suggest course of action for efficient performance of the existing system. Methods: This qualitative & quantitative evaluation was conducted at Provincial Disease Surveillance &Response Unit (PDSRU) Muzaffarabad Azad Jammu & Kashmir during March -April 2019. The database of AFP cases during 2018 was reviewed and relevant stakeholder's interviews were conducted consulting guidelines formulated by the Centre for Disease Control & prevention(CDC) in 2001 for Evaluating Public Health Surveillance Systems. Results: In 2018, a total of 265 AFP cases were registered. The mean age was 65 months (range 01 - 180 months). 59 % (n=157) were male children. 58% of cases were under 05 year's age. Standardized case definition and data format with simple information flow was found. System was flexible enough to incorporate measles and neonatal tetanus cases since 2009. Data quality was excellent (100% zero and monthly reports). A close coordination was observed amongst all relevant stakeholders. Sensitivity was 200%. No polio case was identified and therefore, PPV was zero. Majority of cases were reported by public sector (93%).Sufficient financial as well as skilled human resources were available and hence system found stable. Timeliness of reporting found 90%. Conclusion: The performance of AFP surveillance system in AJ&K is up to the mark. However, there is constant threat of reintroduction of polio virus from adjacent area of Punjab & Khyber Pakhtunkhwa provinces. Highly vigilant AFP surveillance system with capacity of rapid response is the solution. Furthermore, it is vital to sustain the AFP Surveillance till the goal of global polio eradication is achieved.

scholarly journals Evaluation of Acute Flaccid Paralysis Surveillance indicators in Sokoto State, Nigeria, 2012-2019: A secondary data analysis

2020 ◽  
Author(s):  
Ismail Abdullateef Raji ◽  
Auwal Abubakar Usman ◽  
Abdulrahman Ahmad ◽  
Saheed Gidado ◽  
Abdulhakeem Abayomi Olorukooba ◽  
...  
Keyword(s):  
Acute Flaccid Paralysis ◽  
Secondary Data ◽  
High Sensitivity ◽  
Flaccid Paralysis ◽  
World Health ◽  
Surveillance Network ◽  
Polio Virus ◽  
Acute Flaccid Paralysis Surveillance ◽  
Afp Surveillance ◽  
Health Organization

Abstract Background: Nigeria and indeed, entire Africa has been certified free of Wild Polio Virus (WPV) in 2020. However, the continent is still at risk of importation of WPV, especially in states like Sokoto in Nigeria, which has an international border. Furthermore, due to low immunity in some communities in Sokoto, outbreaks of the circulating Vaccine Derived Polio Virus (cVDPV) occur. Therefore, this paper evaluates the Acute Flaccid Paralysis (AFP) surveillance indicators in Sokoto state, Nigeria. Methods: This retrospective study was an analysis of routinely collected AFP surveillance data between 2012 and 2019 by the Sokoto state surveillance network. We assessed the Sokoto state AFP surveillance system using the AFP surveillance performance indicators. We performed all analyses using Microsoft Excel 2019.Results: Cumulatively, 3001 Acute Flaccid Paralysis (AFP) cases were reported over the evaluation period, out of which 1692 (56.4%) were males, and 2478 (82.4%) were below five years. More than half, 1773 (59.1%) had a fever at the beginning of the disease, and 1911 (63.7%) had asymmetric paralysis. The non-polio AFP rate (9.1 to 23.5%) and stool adequacy rate (92.5 to 100%) indicate high sensitivity. The proportion of cases that had stool samples collected early, timely transported to the laboratory and arrived at the laboratory in optimal condition were all above the World Health Organization (WHO) minimum standard of 80%. There was inadequate profile documentation of some suspected cases.Conclusions: Sokoto State has exceeded the WHO minimum standards in most of the AFP surveillance indicators. The performance of the system is sufficient enough to detect any reintroduction of WPV into the state. However, there is a need for improvement in data quality.

scholarly journals The Acute Flaccid Paralysis (AFP) Surveillance System in Yemen, 2010-2015: Descriptive Study Based on Secondary Data Analysis (Preprint)

2019 ◽  
Author(s):  
Khaled Abdullah Almoayed ◽  
Ali Bin Break ◽  
Mutahar Al-Qassimi ◽  
Ali Assabri ◽  
Yousef Khader
Keyword(s):  
Surveillance System ◽  
Acute Flaccid Paralysis ◽  
Descriptive Study ◽  
Flaccid Paralysis ◽  
World Health ◽  
Reference Laboratory ◽  
Sample Collection ◽  
Afp Surveillance ◽  
Stool Specimens ◽  
Central Level

BACKGROUND Acute flaccid paralysis (AFP) surveillance is an essential strategy for poliovirus eradication. OBJECTIVE This study aimed to evaluate the performance of the AFP surveillance system in Yemen from 2010 to 2015, identify components that require strengthening, and compare the indicators by year and governorates. METHODS This descriptive study was based on secondary analysis of AFP surveillance data reported during 2010-2015 from all Yemeni governorates. The World Health Organization (WHO) minimum performance standards were used to evaluate the performance of the AFP surveillance system. RESULTS A total of 3019 AFP cases were reported between January 2010 and December 2015. At the national level, AFP surveillance achieved WHO targets throughout the evaluating period for the nonpolio AFP rate of cases per 100,000 members of the population younger than 15 years of age, proportion of AFP cases reported within 7 days, proportion of AFP cases investigated within 48 hours of notification, proportion of AFP cases with two adequate stool specimens, and proportion of stool specimens from which nonpolio enterovirus was isolated. However, the proportion of specimens that arrived at the central level within 3 days of the first sample collection and the proportion of stool specimens with results sent from the reference laboratory within 28 days of receipt did not reach targets in 2011 and 2015, respectively. CONCLUSIONS The AFP surveillance system in Yemen has met most of the WHO indicator levels. Nevertheless, the evaluation showed areas of weakness regarding the arrival of specimens at the central level within 3 days of the first sample collection and delays in processing of the results and submitting feedback by the laboratory. Therefore, there is a need to strengthen the follow-up of specimens submitted to the laboratory.

scholarly journals Genotyping of non-polio enteroviruses associated with acute flaccid paralysis in Thailand in 2013 and 2014

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Napa Onvimala ◽  
Nathamon Kosoltanapiwat ◽  
Pornpan Pumirat ◽  
Muthita Vanaporn ◽  
Suchitra Nimmanitya ◽  
...  
Keyword(s):  
Acute Flaccid Paralysis ◽  
Flaccid Paralysis ◽  
World Health ◽  
Reference Laboratory ◽  
Mouth Diseases ◽  
Circulation Patterns ◽  
The World ◽  
Afp Surveillance ◽  
Health Organization ◽  
First Time

Abstract Background Acute flaccid paralysis (AFP) surveillance was conducted as part of the World Health Organization’s strategy for completely eradicating poliomyelitis and leaving non-polio enteroviruses NPEVs as one of the main potential causes of AFP. We aimed to detect NPEV in association with AFP. Methods We used 459 isolates reported to be Negative Polio and some NPEVs by the World Health Organization Polio Regional Reference Laboratory (Thailand), which had been obtained during polio surveillance programmes conducted in Thailand in 2013–2014. Of 459 isolates, 35 belonged to the genus Enterovirus by RT-PCR and genotyping by DNA sequencing. Results This study found 17 NPEV genotypes, with 3, 13 and 1 belonging to enterovirus (EV) species A (EV-A), EV-B, and EV-C, respectively. The EV-A types identified included coxsackievirus A2 (CA2), CA4, and EV71, typically associated with hand, foot and mouth diseases. EV-B is the most prevalent cause of AFP in Thailand, while CA21 was the only type of EV-C detected. The EV-B species (13/35; 76.5%) constituted the largest proportion of isolates, followed by EV-A (3/35; 17.6%) and EV-C (1/35; 5.9%). For the EV-B species, Echovirus (E) 30 and CVB were the most frequent isolates. E30, CVB, E14, and E6 were considered endemic strains. Conclusion NPEVs, e.g. CA4, are reported for the first time in Thailand. Despite some limitations to this study, this is the first report on the circulation patterns of NPEVs associated with AFP in Thailand. AFP surveillance has unearthed many unknown NPEVs and, the cases of death due to AFP occur annually. Therefore, it is important to study NPEVs in the wake of the eradication of poliovirus in the context of the continued incidence of paralysis.

scholarly journals Gonotyping of non-polio enteroviruses associated with acute flaccid paralysis in Thailand in 2013 and 2014

2021 ◽  
Author(s):  
Napa Onvimala ◽  
Nathamon Kosoltanapiwat ◽  
Pornpan Pumirat ◽  
Muthita Vanaporn ◽  
Suchitra Nimmanitya ◽  
...  
Keyword(s):  
Acute Flaccid Paralysis ◽  
Flaccid Paralysis ◽  
World Health ◽  
Reference Laboratory ◽  
Mouth Diseases ◽  
Circulation Patterns ◽  
The World ◽  
Afp Surveillance ◽  
Health Organization ◽  
First Time

Abstract Background Acute flaccid paralysis (AFP) surveillance was conducted as part of the World Health Organization’s strategy for completely eradicating poliomyelitis and leaving non-polio enteroviruses NPEVs as one of the main potential causes of AFP. We aimed to detect NPEV in association with AFP.Methods We used 459 isolates reported to be Negative Polio and some NPEVs by the World Health Organization Polio Regional Reference Laboratory (Thailand), which had been obtained during polio surveillance programmes conducted in Thailand in 2013–2014. Of 459 isolates, 35 belonged to the genus Enterovirus by RT-PCR and genotyping by DNA sequencing.Results This study found 17 NPEV genotypes, with 3, 13 and 1 belonging to enterovirus (EV) species A (EV-A), EV-B, and EV-C, respectively. The EV-A types identified included coxsackievirus A2 (CA2), CA4, and EV71, typically associated with hand, foot and mouth diseases. EV-B is the most prevalent cause of AFP in Thailand, while CA21 was the only type of EV-C detected. The EV-B species (13/35; 76.5%) constituted the largest proportion of isolates, followed by EV-A (3/35; 17.6%) and EV-C (1/35; 5.9%). For the EV-B species, Echovirus (E) 30 and CVB were the most frequent isolates. E30, CVB, E14, and E6 were considered endemic strains.Conclusion NPEVs, e.g. CA4, are reported for the first time in Thailand. Despite some limitations to this study, this is the first report on the circulation patterns of NPEVs associated with AFP in Thailand. AFP surveillance has unearthed many unknown NPEVs and, the cases of death due to AFP occur annually. Therefore, it is important to study NPEVs in the wake of the eradication of poliovirus in the context of the continued incidence of paralysis.

scholarly journals Acute Flaccid Paralysis Surveillance system Evaluation, Oyo state, Nigeria; 2008-2014

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Maureen Anyanwu
Keyword(s):  
Surveillance System ◽  
Disease Surveillance ◽  
Acute Flaccid Paralysis ◽  
Case Definition ◽  
Operating Conditions ◽  
Flaccid Paralysis ◽  
Cold Chain ◽  
Acute Flaccid Paralysis Surveillance ◽  
Afp Surveillance ◽  
The Mean

ObjectiveWe evaluated the AFP surveillance system in Oyo State to assessits attributes and determine if it was meeting its set objectives.IntroductionIn September, 2015, Nigeria was delisted from the list of polioendemic countries globally. To be certified polio free, the countrymust attain and maintain certification standard Acute Flaccid Paralysis(AFP) surveillance for additional two-years. In Oyo State, no case ofWild Polio Virus (WPV) has been reported since February, 2009.MethodsWe used the Centre for Disease Control and Prevention updatedguidelines for evaluating public health surveillance system.We conducted a retrospective review of AFP surveillance databetween 1stJanuary, 2008 and 31stDecember, 2014. We conductedin-depth interviews with identified stakeholders. Semi-structuredquestionnaires were administered to Disease Surveillance andNotification Officers (DSNOs) and AFP focal persons. Univariateanalysis was performed by calculating frequencies, means andproportions using Microsoft Excel 2010.ResultsThe case definition of AFP and the tools for reporting are simple.Of the 897 AFP cases detected during the period under review(2008-2014), 20 (2.2%) were laboratory confirmed WPV. Thesensitivity of the system between 2008 and 2014 measured by theAnnualized Non-Polio AFP (NPAFP) rate was consistently abovethe target. of≥2/100,000 population(Mean=3.96, Standard deviation(SD): 0.48). The mean NPAFP rate for underperforming LGAs duringthe review period was 1.6, SD: 0.31. The mean Stool adequacy andTimeliness were 91.43% (SD: 18.3) and 91.3% (SD: 20.3) abovethe target of≥80% respectively. The mean Data quality was 90%(target is≥90; SD: 3.8). Positive Predictive Value (PVP) was 2%(2008 -2009), and 0% in 2010-2014.ConclusionsThe Oyo State AFP surveillance system is simple, flexible,sensitive and meeting its set objectives. However, PVP was low andthe system’s operating conditions are not stable. All the LGAs, at onepoint during the period under review did not meet the NPAFP andNPENT rates. We recommended that more logistic support shouldbe provided for non-performing LGAs to improve case reporting,investigation, and response. DSNOs should be re -sensitized onreverse cold chain, so as to improve the NPENT rate

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