Genetic predictors of arterial hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 29-35
Author(s):  
Elena Viktorovna Korneeva ◽  
Mikhail Ivanovich Voevoda
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Young Patients ◽  
Polymorphic Loci ◽  
Ace Gene ◽  
The Metabolic Syndrome ◽  
Genetic Predictors ◽  
Αiibβ3 Integrin

The paper presents the results of studying the polymorphism of the genes rs1799752 of the ACE gene, αIIbβ3 integrin, rs1378942 of the CSK gene in the development of arterial hypertension in young patients with metabolic syndrome. Arterial hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. The occurrence of mutant alleles of the studied genes among the examined patients is quite high: thus, the carriage of the homozygous DD variant is 21.6%, and the carriage of the mutant D allele of the ACE gene is 47.4%. A high risk of developing hypertension in patients with MS was detected in carriers of the T rs1378942 CSK allele - 54.8%, which was most often observed in a combination of polymorphic loci of the ACE and CSK genes (p = 0.0053).

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

ARTERIAL HYPERTENSION AND COMORBIDITY (REVIEW)

2020 ◽  
Vol 2 (1) ◽  
pp. 9-13
Author(s):  
Irina Agababyan ◽  
◽  
Shukhrat Ziyadullaev ◽  
Jamshid Ismailov
Keyword(s):  
Quality Of Life ◽  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
The Metabolic Syndrome

Today, hypertension is considered by many authors within the framework of the manifestation of the metabolic syndrome. It has been established that in persons with hypertension in 60% of cases, various variants of MS are found. In addition, hypertension is a factor that reduces the quality of life of patients, especially those with comorbid pathology

scholarly journals An epigenetic map of age-associated autosomal loci in northern European families at high risk for the metabolic syndrome

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Omar Ali ◽  
Diana Cerjak ◽  
Jack W Kent ◽  
Roland James ◽  
John Blangero ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
The Metabolic Syndrome ◽  
Northern European

scholarly journals The Impact of Metabolic Syndrome and Its Components on Female Sexual Dysfunction: A Narrative Mini-Review

2018 ◽  
Vol 12 (2) ◽  
pp. 57-63
Author(s):  
Simona Di Francesco ◽  
Marika Caruso ◽  
Iole Robuffo ◽  
Andrea Militello ◽  
Elena Toniato
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Sexual Dysfunction ◽  
Arterial Hypertension ◽  
Sexual Function ◽  
Sexual Desire ◽  
Female Sexual Dysfunction ◽  
Systemic Arterial Hypertension ◽  
The Metabolic Syndrome ◽  
The Impact

Background: The impact of metabolic syndrome on female sexual dysfunction received modest consideration in clinical practice. The aim of the research was to analyze the international literature to determine the relationship between the metabolic syndrome, its components and female sexual disorders. Methods: We identified relevant full-length papers by electronic databases as Index Medicus/Medline, Scopus, Life Science Journals, from 2005 to the present. Studies were searched using the following as search query: metabolic syndrome, female sexual dysfunction, obesity, systemic arterial hypertension, diabetes mellitus, dyslipidemia. Results: Women with metabolic syndrome showed higher prevalence of sexual inactivity and low sexual desire, orgasm and satisfaction respect to women without metabolic syndrome. Particularly metabolic components as diabetes mellitus, dy-slipidemia, systemic arterial hypertension were strongly associated with lower sexual desire, activity and Female Sexual Function Index total score. In contrast, other studies showed no relationship. Conclusion: Our study showed that in the clinical evaluation of women with metabolic syndrome routine inquiring about female sexual dysfunction should be recommended to ameliorate sexual function and quality of life. However more prospective and longitudinal studies on the sexual effects of metabolic syndrome should also be suggested to know the factors related to women's sexuality better.

scholarly journals Arginine and aerobic training prevent endothelial and metabolic alterations in rats at high risk for the development of the metabolic syndrome – CORRIGENDUM

2017 ◽  
Vol 118 (11) ◽  
pp. 998-998
Author(s):  
Renata Medeiros ◽  
Thaiane Gaique ◽  
Thais Bento-Bernardes ◽  
Raquel Kindlovits ◽  
Tamiris Gomes ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Aerobic Training ◽  
Metabolic Alterations ◽  
The Metabolic Syndrome

scholarly journals Comorbid pathology and prognosis of breast cancer in women in menopause.

2018 ◽  
Vol 96 (1) ◽  
pp. 55-59
Author(s):  
Nailya S. Asfandiyarova ◽  
E. P. Kulikov ◽  
A. S. Skopin ◽  
A. N. Demko ◽  
A. A. Nikiforov
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Visceral Obesity ◽  
Suppressor Cells ◽  
Cancer Prognosis ◽  
Lymph Node Status ◽  
Regional Lymph Nodes ◽  
The Metabolic Syndrome ◽  
Menopausal Women

Comorbid pathology is important in the survival of patients with breast cancer. The main aim of the present study was to investigate prognostic criteria of the 5-year survival menopausal women with breast cancer, including both the classic criteria (age, tumor size, lymph node status, hormonal status) and the presence of comorbid pathology (arterial hypertension, visceral obesity, diabetes mellitus, metabolic syndrome, immunodeficiency). A prospective cohort study included 98 patients with breast cancer (aged 63 ± 9 years, BMI 31.6 ± 4.8 kg/m2). Criteria favorable short-term (5 years) of the cancer prognosis of breast cancer in menopausal women are the size of the tumor less than 5 cm, the absence of metastases in regional lymph nodes, and the absence of the metabolic syndrome, dyslipidemia, high activity of suppressor cells. Age, anthropometric indices (BMI, waist circumference etc.), presence of arterial hypertension do not give information about the 5-year survival rate in breast cancer.

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