With rheumatoid arthritis (RA), along with the main manifestations, there are a variety of neurological, neurotic and endocrine symptoms caused by immune effects. In addition, the chronic course of RA and the disability of patients leads to a violation of their usual way of life, a change in the circle of vital interests and the formation of neurotic disorders. Neurotic disorders are accompanied by a violation of the plasticity of the nervous system -its ability to regulate all structural and functional organizations and adaptation processes, which in turn leads to profound changes in immunological homeostasis, hormonal balance and all types of metabolism