RNA viruses: clinical and diagnostic features and principles of treatment

2020 ◽  
pp. 66-73
Author(s):  
E. Levkova ◽  
S. Savin ◽  
K. Gulieva

The review presents generalized data on respiratory RNA viruses, features of clinical course and diagnostic algorithm. Special attention is paid to the principles oftreatment of diseases caused by RNA viruses.

2016 ◽  
Vol 16 ◽  
pp. S111
Author(s):  
Ekaterina Nesterova ◽  
Alla Kovrigina ◽  
Jana Mangasarova ◽  
Lybov Plastinina ◽  
Tatyana Obukhova ◽  
...  

1979 ◽  
Vol 88 (4) ◽  
pp. 486-494 ◽  
Author(s):  
Michael Setzen ◽  
Steven Sobol ◽  
James M. Toomey

The clinical manifestations of 29 recently encountered sarcomas of the head and neck were analyzed in an attempt to define more accurately the diagnostic characteristics and therapeutic responses of these unusual tumors. The host factors of age, sex distribution, race, habits and associated features differ sufficiently to distinguish the sarcoma from the carcinoma population. In addition, the clinical course of sarcoma patients as monitored by mode of presentation, site of involvement, tumor histology, diagnostic features and certain elements of management and outcome, further indicates that these tumors can be defined and managed as a distinct group of lesions. A review of the recent literature supports the major conclusions of this study.


2017 ◽  
Vol 7 ◽  
pp. 157-167
Author(s):  
Farhad B. Naini ◽  
Daljit S. Gill

This article describes the principles of orthognathic surgical correction of skeletal anterior open bite (AOB), including a description of the aetiological factors involved in the development of predominantly skeletal AOBs, description of the presenting diagnostic features, the principles of treatment planning, orthodontic preparation, and postoperative requirements.


Author(s):  
М.Е. Zapolsky ◽  
М.М. Lebediuk ◽  
N.B. Prokofyeva ◽  
V.V. Goncharenko ◽  
S.V. Nerubashchenko

The modern classification of autoimmune bullous dermatoses is represented by three groups of diseases that have not only clinical, but also histomorphological, histochemical and immunogenetic similarities. Autoimmune bullous dermatoses are a group of heterogeneous diseases accompanied by the formation of blisters and erosions on the skin and/or mucous membranes under the influence of specific autoimmune complexes. The main clinical manifestations and diagnostic markers of autoimmune bullous dermatoses (ABD) belonging to the pemphigus group are considered.Objective — to analyze the prevalence of clinical forms of pemphigus in the southern region of Ukraine for the period from 2010 to 2020.Materials and methods. The observation group consisted of 88 patients aged 21 to 75 years. The features of clinical manifestations of typical and atypical forms of pemphigus have been studied, a diagnostic algorithm and criteria for the effectiveness of treatment in the early stages of the disease have been developed.Results and discussion. Pemphigus vulgaris was found in 61 (69.3 %), pemphigus vegetans — in 7 (7.9 %), pemphigus erythematosus — in 6 (6.8 %), herpetiform pemphigus — in 4 (4.5 %), IgA pemphigus — in 3 (3.4 %), paraneoplastic pemphigus — in 3 (3.4 %) patients.Conclusions. Modern clinical diagnostic features of ABD (pemphigus group) require the inclusion of immunofluorescence microscopy, direct and indirect enzyme immunoassay in laboratory screening. Not only positive clinical dynamics, but also the rate of disappearance of autoantibodies that induce the diseases (desmoglein, desmoplakin, periplakin, etc.) should be considered the criteria of the effectiveness of treatment of patients with ABD. At the same time, knowledge of the clinical features of ABD and the diseases that mimic them remains an important aspect.


Author(s):  
Elisabetta Cariani ◽  
Erica Villa ◽  
Cristina Rota ◽  
Rosina Critelli ◽  
Tommaso Trenti

AbstractHepatitis C virus (HCV) infection is frequently characterized by evolution to chronicity and by a variable clinical course of the disease. The clinical heterogeneities of HCV infection and the imperfect predictability of the response to interferon (IFN) have suggested the need to search for a genetic basis of clinical features. This led to the discovery of genetic polymorphisms playing a major role in the evolution of infection, as well as on treatment response and adverse effects. This review will cover recent reports on the subject, focusing on the potential use of the new genetic markers in the diagnostic algorithm for the stratification of patients for personalized antiviral regimens.


2020 ◽  
Vol 1 (77) ◽  
pp. 99-106
Author(s):  
N. M. Leontieva ◽  
I. V. Demko ◽  
E. A. Sobko ◽  
O. P. Ischenko

Today in the world there is a high prevalence of asthma, and the mild severity occupies a leading position in the structure of morbidity. A mild asthma is a pathology that, with a prolonged asymptomatic course, can lead to severe exacerbations, and even death. Despite this, at present there are difficulties leading to an insufficient and untimely diagnosis of asthma, as a result of which exacerbations are often recorded in patients with a mild severity of the disease. The literature review examined the clinical features of mild asthma, as well as the modern principles of treatment of patients with mild disease severity. In addition, a review of recent studies aimed at studying morphological and pathophysiological changes in mild asthma is presented. Mild asthma, as a rule, is stable, but sometimes it can spontaneously develop into extremely severe, and the causes of such changes remain unclear. The analysis of the studies revealed endogenous and exogenous factors that affect the induction of bronchial asthma and exacerbate its course. It is also important that bronchial obstruction, apparently, appears from the first years of life and persists in the future, in connection with which it is important to understand the value of diagnosis measures and the effectiveness of interventions in the early stages of bronchial obstruction to prevent disease progression. In this regard, the problems of early diagnosis of mild asthma and the timely appointment of appropriate therapy remain today important and relevant.


2021 ◽  
Vol 11 (3) ◽  
pp. 12-36
Author(s):  
S. S. Nikitin ◽  
S. N. Bardakov ◽  
N. A. Suponeva ◽  
I. V. Zhirov ◽  
T. A. Adyan ◽  
...  

Transthyretin amyloidosis (ATTR-amyloidosis) is a systemic progressive fatal disease, for which a modifying therapy has recently been proposed that delays the progression of the disease and improves the patient’s quality of life. The delay in the diagnosis of ATTR-amyloidosis is associated with the heterogeneity of the manifestations of the disease, as well as insufficient awareness of doctors of different specialties about the disease. A review of recent studies on the symptomatology, diagnosis, molecular genetic characteristics of ATTR-amyloidosis and the most common forms of the disease with the predominant involvement of peripheral nerves and the heart, as well as the kidneys, gastrointestinal tract, and eyes is presented. The international consensus recommendations for the diagnosis of suspected ATTR-amyloidosis using modern methods that facilitate early and accurate diagnosis are discussed. The reasons and the most frequent misdiagnoses of ATTR-amyloidosis, which also lead to a delay in the timely appointment of therapy, are considered. Molecular genetic testing should be considered early in the evaluation of a patient with unexplained peripheral neuropathy and cardiomyopathy. A diagnostic algorithm based on the initial symptoms and manifestations of the cardiovascular and nervous systems facilitates the identification of a patient with clinical suspicion of ATTR-amyloidosis by the general practitioner. Early diagnosis is critically important for patients with ATTR polyneuropathy, since the early prescription of Vindakel (tafamidis), registered in the Russian Federation in 2017, allows a significant clinical effect to be obtained. Timely administration of Vindakel significantly slows down the progression of the disease, improves the prognosis and quali  ty of life in patients with ATTR polyneuropathy.


1995 ◽  
Vol 70 (7) ◽  
pp. 634-640 ◽  
Author(s):  
Frank Cetta ◽  
Patrick W. O'Leary ◽  
James B. Seward ◽  
David J. Driscoll

2021 ◽  
Vol 2 (4) ◽  
pp. 01-04
Author(s):  
Igor Klepikov

It is difficult to predict how the founder of psychoanalysis, Sigmund Freud, would react to an attempt to link his theory and the method of treating mental disorders based on it [1] with such a purely physical disease as acute pneumonia (AP). It is unlikely that such an innovation could cause full approval and support. However, in this context, we are not talking about psychoanalysis as a therapeutic method for AP. In this case, only the diagnostic features of this technique are of interest. The essence of psychoanalysis, which is based on the search for the causes of the so-called echoes of the past, as well as the connection between conscious and unconscious phenomena, can be useful in order to understand the causes of errors and paradoxes that exist in solving the problem of AP. In other words, we are not talking about the nuances of the disease itself, but about the peculiarities of its nature, since the interpretation of the essence of AP determines the principles of treatment and the final results.


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