Grooved pins. Half-length reverse-taper grooved

2015 ◽  
Keyword(s):  
2017 ◽  
Vol 12 (1) ◽  
pp. 126-134
Author(s):  
A.M. Ilyasov

Based on the generalized Perkins-Kern-Nordgren model (PKN) for the development of a hyperbolic type vertical hydraulic fracture, an exact solution is obtained for the hydraulic fracture self-oscillations after terminating the fracturing fluid injection. These oscillations are excited by a rarefaction wave that occurs after the injection is stopped. The obtained solution was used to estimate the height, width and half-length of the hydraulic fracture at the time of stopping the hydraulic fracturing fluid injection based on the bottomhole pressure gauge data.


2002 ◽  
Vol 76 (15) ◽  
pp. 7651-7660 ◽  
Author(s):  
Grace S. Yang ◽  
Michael Schmidt ◽  
Ziying Yan ◽  
Jonathan D. Lindbloom ◽  
Thomas C. Harding ◽  
...  

ABSTRACT Gene therapy vectors based on adeno-associated viruses (AAVs) show promise for the treatment of retinal degenerative diseases. In prior work, subretinal injections of AAV2, AAV5, and AAV2 pseudotyped with AAV5 capsids (AAV2/5) showed variable retinal pigmented epithelium (RPE) and photoreceptor cell transduction, while AAV2/1 predominantly transduced the RPE. To more thoroughly compare the efficiencies of gene transfer of AAV2, AAV3, AAV5, and AAV6, we quantified, using stereological methods, the kinetics and efficiency of AAV transduction to mouse photoreceptor cells. We observed persistent photoreceptor and RPE transduction by AAV5 and AAV2 up to 31 weeks and found that AAV5 transduced a greater volume than AAV2. AAV5 containing full-length or half-length genomes and AAV2/5 transduced comparable numbers of photoreceptor cells with similar rates of onset of expression. Compared to AAV2, AAV5 transduced significantly greater numbers of photoreceptor cells at 5 and 15 weeks after surgery (greater than 1,000 times and up to 400 times more, respectively). Also, there were 30 times more genome copies in eyes injected with AAV2/5 than in eyes injected with AAV2. Comparing AAVs with half-length genomes, AAV5 transduced only four times more photoreceptor cells than AAV2 at 5 weeks and nearly equivalent numbers at 15 weeks. The enhancement of transduction was seen at the DNA level, with 50 times more viral genome copies in retinas injected with AAV having short genomes than in retinas injected with AAV containing full-length ones. Subretinal injection of AAV2/6 showed only RPE transduction at 5 and 15 weeks, while AAV2/3 did not transduce retinal cells. We conclude that varying genome length and AAV capsids may allow for improved expression and/or gene transfer to specific cell types in the retina.


2020 ◽  
Vol 2020 (3) ◽  
pp. 94-98
Author(s):  
V. Shulika ◽  

The article is dedicated to the iconostasis of the Assumption Cathedral in Okhtyrka (1738). The iconostasis was installed at the expense of O. Lesevytsky (a colonel of Okhtyrka regiment and a brigadier of Sloboda regiments). The icons were painted by Kharkiv icon painter V. Dmitriev. While painting he was working in Kiev‑Pechersk Laura. The iconostasis of the Assumption Cathedral became an example of an innovative decision of altar partitions not only in Slobozhanshchyna, but also in the whole of Ukraine. The altar partitions reflected the stylistic innovations relevant for the first half of the 18th century – a combination of Rococo and Classicism. The iconostasis of 1738 demonstrates that the spread of these styles in Slobozhanshchyna took place much earlier than in Central and Western Ukraine, and the sacred art of Slobozhanshchyna regiments had its own path of development. The iconostasis of the Assumption Cathedral became the first altar partition, which broke with traditional for Ukraine and, in particular, for Slobozhanshchyna, stylistic and iconographic decisions of altar partitions. It can be considered the first altar partition, which opens a new era in the history of Ukrainian iconostasis. A new solution for iconostasis in Slobozhanshchyna was the introduction of the metric type in the construction of tiers (the rhythmic type was traditionally used before that), the elimination of the Deisus tier, which was replaced by a large-format Holiday tier. The iconostasis also shows internal influences. Thus, the Sovereign tier of the iconostasis presented images of Christ, the Birth‑Giver of God and saints, depicted in full length, which was widespread in Kyiv and had not previously been typical in Slobozhanshchyna (traditionally the Sovereign (bottom) tier of the iconostasis in Slobozhanshchyna consisted of half‑length images). A new solution of the Sovereign tier of the iconostasis was probably proposed by V. Dmitriev, who could transfer part of Kyiv icon-painting tradition to Slobozhanshchyna.


2022 ◽  
Author(s):  
Ahmed Elsayed Hegazy ◽  
Mohammed Rashdi

Abstract Pressure transient analysis (PTA) has been used as one of the important reservoir surveillance tools for tight condensate-rich gas fields in Sultanate of Oman. The main objectives of PTA in those fields were to define the dynamic permeability of such tight formations, to define actual total Skin factors for such heavily fractured wells, and to assess impairment due to condensate banking around wellbores. After long production, more objectives became also necessary like assessing impairment due to poor clean-up of fractures placed in depleted layers, assessing newly proposed Massive fracturing strategy, assessing well-design and fracture strategies of newly drilled Horizontal wells, targeting the un-depleted tight layers, and impairment due to halite scaling. Therefore, the main objective of this paper is to address all the above complications to improve well and reservoir modeling for better development planning. In order to realize most of the above objectives, about 21 PTA acquisitions have been done in one of the mature gas fields in Oman, developed by more than 200 fractured wells, and on production for 25 years. In this study, an extensive PTA revision was done to address main issues of this field. Most of the actual fracture dynamic parameters (i.e. frac half-length, frac width, frac conductivity, etc.) have been estimated and compared with designed parameters. In addition, overall wells fracturing responses have been defined, categorized into strong and weak frac performances, proposing suitable interpretation and modeling workflow for each case. In this study, more reasonable permeability values have been estimated for individual layers, improving the dynamic modeling significantly. In addition, it is found that late hook-up of fractured wells leads to very poor fractures clean out in pressure-depleted layers, causing the weak frac performance. In addition, the actual frac parameters (i.e. frac-half-length) found to be much lower than designed/expected before implementation. This helped to improve well and fracturing design and implementation for next vertical and horizontal wells, improving their performances. All the observed PTA responses (fracturing, condensate-banking, Halite-scaling, wells interference) have been matched and proved using sophisticated single and sector numerical simulation models, which have been incorporated into full-field models, causing significant improvements in field production forecasts and field development planning (FDP).


2016 ◽  
Vol 9 (1) ◽  
pp. 207-215 ◽  
Author(s):  
Hongling Zhang ◽  
Jing Wang ◽  
Haiyong Zhang

Shale gas is one of the primary types of unconventional reservoirs to be exploited in search for long-lasting resources. Production from shale gas reservoirs requires horizontal drilling with hydraulic fracturing to achieve the most economic production. However, plenty of parameters (e.g., fracture conductivity, fracture spacing, half-length, matrix permeability, and porosity,etc) have high uncertainty that may cause unexpected high cost. Therefore, to develop an efficient and practical method for quantifying uncertainty and optimizing shale-gas production is highly desirable. This paper focuses on analyzing the main factors during gas production, including petro-physical parameters, hydraulic fracture parameters, and work conditions on shale-gas production performances. Firstly, numerous key parameters of shale-gas production from the fourteen best-known shale gas reservoirs in the United States are selected through the correlation analysis. Secondly, a grey relational grade method is used to quantitatively estimate the potential of developing target shale gas reservoirs as well as the impact ranking of these factors. Analyses on production data of many shale-gas reservoirs indicate that the recovery efficiencies are highly correlated with the major parameters predicted by the new method. Among all main factors, the impact ranking of major factors, from more important to less important, is matrix permeability, fracture conductivity, fracture density of hydraulic fracturing, reservoir pressure, total organic content (TOC), fracture half-length, adsorbed gas, reservoir thickness, reservoir depth, and clay content. This work can provide significant insights into quantifying the evaluation of the development potential of shale gas reservoirs, the influence degree of main factors, and optimization of shale gas production.


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