Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKD

There is greater than tenfold variation in nephron number of the human kidney at birth. Although low nephron number is a recognized risk factor for CKD, its determinants are poorly understood. Evolutionary medicine represents a new discipline that seeks evolutionary explanations for disease, broadening perspectives on research and public health initiatives. Evolution of the kidney, an organ rich in mitochondria, has been driven by natural selection for reproductive fitness constrained by energy availability. Over the past 2 million years, rapid growth of an energy-demanding brain in Homo sapiens enabled hominid adaptation to environmental extremes through selection for mutations in mitochondrial and nuclear DNA epigenetically regulated by allocation of energy to developing organs. Maternal undernutrition or hypoxia results in intrauterine growth restriction or preterm birth, resulting in low birth weight and low nephron number. Regulated through placental transfer, environmental oxygen and nutrients signal nephron progenitor cells to reprogram metabolism from glycolysis to oxidative phosphorylation. These processes are modulated by counterbalancing anabolic and catabolic metabolic pathways that evolved from prokaryote homologs and by hypoxia-driven and autophagy pathways that evolved in eukaryotes. Regulation of nephron differentiation by histone modifications and DNA methyltransferases provide epigenetic control of nephron number in response to energy available to the fetus. Developmental plasticity of nephrogenesis represents an evolved life history strategy that prioritizes energy to early brain growth with adequate kidney function through reproductive years, the trade-off being increasing prevalence of CKD delayed until later adulthood. The research implications of this evolutionary analysis are to identify regulatory pathways of energy allocation directing nephrogenesis while accounting for the different life history strategies of animal models such as the mouse. The clinical implications are to optimize nutrition and minimize hypoxic/toxic stressors in childbearing women and children in early postnatal development.

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Irreversible impact of early thermal conditions: an integrative study of developmental plasticity linked to mobility in a butterfly species

Journal of Experimental Biology ◽

10.1242/jeb.243724 ◽

2022 ◽

Author(s):

Anaïs Degut ◽

Klaus Fischer ◽

Martin Quque ◽

François Criscuolo ◽

Peter Michalik ◽

...

Keyword(s):

Life History ◽

Seasonal Changes ◽

Developmental Plasticity ◽

Thermal Conditions ◽

Life History Strategies ◽

Butterfly Species ◽

Oxidative Markers ◽

Displacement Capacity ◽

Irreversible Effects ◽

Cool Conditions

Within populations, phenotypic plasticity may allow adaptive phenotypic variation in response to selection generated by environmental heterogeneity. For instance, in multivoltine species, seasonal changes between and within generations may trigger morphological and physiological variation enhancing fitness under different environmental conditions. These seasonal changes may irreversibly affect adult phenotypes when experienced during development. Yet, the irreversible effects of developmental plasticity on adult morphology have rarely been linked to life-history traits even though they may affect different fitness components such as reproduction, mobility and self-maintenance. To address this issue, we raised larvae of Pieris napi butterflies under warm or cool conditions to subsequently compare adult performance in terms of reproduction performance (as assessed through fecundity), displacement capacity (as assessed through flight propensity and endurance) and self-maintenance (as assessed through the measurement of oxidative markers). As expected in ectotherms, individuals developed faster under warm conditions and were smaller than individuals developing under cool conditions. They also had more slender wings and showed a higher wing surface ratio. These morphological differences were associated with changes in the reproductive and flight performances of adults, as individuals developing under warm conditions laid fewer eggs and flew larger distances. Accordingly, the examination of their oxidative status suggested that individuals developing under warm conditions invested more strongly into self-maintenance than individuals developing under cool conditions (possibly at the expense of reproduction). Overall, our results indicate that developmental conditions have long-term consequences on several adult traits in butterflies. This plasticity likely acts on life history strategies for each generation to keep pace with seasonal variations and may facilitate acclimation processes in the context of climate change.

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Habitat–performance relationships: finding the right metric at a given spatial scale

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2010.0085 ◽

2010 ◽

Vol 365 (1550) ◽

pp. 2255-2265 ◽

Cited By ~ 186

Author(s):

Jean-Michel Gaillard ◽

Mark Hebblewhite ◽

Anne Loison ◽

Mark Fuller ◽

Roger Powell ◽

...

Keyword(s):

Life History ◽

Resource Selection ◽

Life History Strategies ◽

Animal Performance ◽

Global Positioning ◽

Selection For ◽

The Right ◽

Conceptual Difficulties ◽

Long Term Studies

The field of habitat ecology has been muddled by imprecise terminology regarding what constitutes habitat, and how importance is measured through use, selection, avoidance and other bio-statistical terminology. Added to the confusion is the idea that habitat is scale-specific. Despite these conceptual difficulties, ecologists have made advances in understanding ‘how habitats are important to animals’, and data from animal-borne global positioning system (GPS) units have the potential to help this clarification. Here, we propose a new conceptual framework to connect habitats with measures of animal performance itself—towards assessing habitat–performance relationship (HPR). Long-term studies will be needed to estimate consequences of habitat selection for animal performance. GPS data from wildlife can provide new approaches for studying useful correlates of performance that we review. Recent examples include merging traditional resource selection studies with information about resources used at different critical life-history events (e.g. nesting, calving, migration), uncovering habitats that facilitate movement or foraging and, ultimately, comparing resources used through different life-history strategies with those resulting in death. By integrating data from GPS receivers with other animal-borne technologies and combining those data with additional life-history information, we believe understanding the drivers of HPRs will inform animal ecology and improve conservation.

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Growth patterns and life-history strategies in Placodontia (Diapsida: Sauropterygia)

Royal Society Open Science ◽

10.1098/rsos.140440 ◽

2015 ◽

Vol 2 (7) ◽

pp. 140440 ◽

Cited By ~ 14

Author(s):

Nicole Klein ◽

James M. Neenan ◽

Torsten M. Scheyer ◽

Eva Maria Griebeler

Keyword(s):

Life History ◽

Bone Tissue ◽

Developmental Plasticity ◽

Growth Models ◽

Age At Onset ◽

Growth Curves ◽

Growth Patterns ◽

Tissue Type ◽

Life History Strategies ◽

Long Bone

Placodontia is a clade of durophagous, near shore marine reptiles from Triassic sediments of modern-day Europe, Middle East and China. Although much is known about their primary anatomy and palaeoecology, relatively little has been published regarding their life history, i.e. ageing, maturation and growth. Here, growth records derived from long bone histological data of placodont individuals are described and modelled to assess placodont growth and life-history strategies. Growth modelling methods are used to confirm traits documented in the growth record (age at onset of sexual maturity, age when asymptotic length was achieved, age at death, maximum longevity) and also to estimate undocumented traits. Based on these growth models, generalized estimates of these traits are established for each taxon. Overall differences in bone tissue types and resulting growth curves indicate different growth patterns and life-history strategies between different taxa of Placodontia. Psephoderma and Paraplacodus grew with lamellar-zonal bone tissue type and show growth patterns as seen in modern reptiles. Placodontia indet. aff. Cyamodus and some Placodontia indet. show a unique combination of fibrolamellar bone tissue regularly stratified by growth marks, a pattern absent in modern sauropsids. The bone tissue type of Placodontia indet. aff. Cyamodus and Placodontia indet. indicates a significantly increased basal metabolic rate when compared with modern reptiles. Double lines of arrested growth, non-annual rest lines in annuli, and subcycles that stratify zones suggest high dependence of placodont growth on endogenous and exogenous factors. Histological and modelled differences within taxa point to high individual developmental plasticity but sexual dimorphism in growth patterns and the presence of different taxa in the sample cannot be ruled out.

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Hormones and Behavior

The Oxford Handbook of Evolutionary Psychology and Behavioral Endocrinology ◽

10.1093/oxfordhb/9780190649739.013.2 ◽

2019 ◽

pp. 11-26

Author(s):

Maren N. Vitousek ◽

Laura A. Schoenle

Keyword(s):

Life History ◽

Life Histories ◽

Life History Traits ◽

Developmental Plasticity ◽

Endocrine System ◽

Phenotypic Traits ◽

Social Environments ◽

Trade Offs ◽

And Behavior

Hormones mediate the expression of life history traits—phenotypic traits that contribute to lifetime fitness (i.e., reproductive timing, growth rate, number and size of offspring). The endocrine system shapes phenotype by organizing tissues during developmental periods and by activating changes in behavior, physiology, and morphology in response to varying physical and social environments. Because hormones can simultaneously regulate many traits (hormonal pleiotropy), they are important mediators of life history trade-offs among growth, reproduction, and survival. This chapter reviews the role of hormones in shaping life histories with an emphasis on developmental plasticity and reversible flexibility in endocrine and life history traits. It also discusses the advantages of studying hormone–behavior interactions from an evolutionary perspective. Recent research in evolutionary endocrinology has provided insight into the heritability of endocrine traits, how selection on hormone systems may influence the evolution of life histories, and the role of hormonal pleiotropy in driving or constraining evolution.

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Exposure to glucocorticoids alters life history strategies in a facultatively paedomorphic salamander

Journal of Experimental Zoology Part A Ecological and Integrative Physiology ◽

10.1002/jez.2445 ◽

2021 ◽

Author(s):

Jason R. Bohenek ◽

Christopher J. Leary ◽

William J. Resetarits

Keyword(s):

Life History ◽

Life History Strategies

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Natural variation in plant telomere length is associated with flowering time

The Plant Cell ◽

10.1093/plcell/koab022 ◽

2021 ◽

Author(s):

Jae Young Choi ◽

Liliia R Abdulkina ◽

Jun Yin ◽

Inna B Chastukhina ◽

John T Lovell ◽

...

Keyword(s):

Life History ◽

Telomere Length ◽

Flowering Time ◽

Dna Sequences ◽

Genome Wide Association Study ◽

Genomic Analysis ◽

Life History Strategies ◽

Length Variation ◽

Chromosomal Structure ◽

Chromosome Integrity

Abstract Telomeres are highly repetitive DNA sequences found at the ends of chromosomes that protect the chromosomes from deterioration during cell division. Here, using whole genome re-sequencing and terminal restriction fragment assays, we found substantial natural intraspecific variation in telomere length in Arabidopsis thaliana, rice (Oryza sativa), and maize (Zea mays). Genome-wide association study (GWAS) mapping in A. thaliana identified 13 regions with GWAS-significant associations underlying telomere length variation, including a region that harbors the telomerase reverse transcriptase (TERT) gene. Population genomic analysis provided evidence for a selective sweep at the TERT region associated with longer telomeres. We found that telomere length is negatively correlated with flowering time variation not only in A. thaliana, but also in maize and rice, indicating a link between life history traits and chromosome integrity. Our results point to several possible reasons for this correlation, including the possibility that longer telomeres may be more adaptive in plants that have faster developmental rates (and therefore flower earlier). Our work suggests that chromosomal structure itself might be an adaptive trait associated with plant life history strategies.

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