Faculty Opinions recommendation of Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor.

2003 ◽  
Author(s):  
Elena Conti
Keyword(s):  
Signal Recognition Particle ◽  
Beta Subunit ◽  
Structural Basis ◽  
Signal Recognition ◽  
Signal Recognition Particle Receptor

SRP RNA Remodeling by SRP68 Explains Its Role in Protein Translocation

Science ◽  
2014 ◽  
Vol 344 (6179) ◽  
pp. 101-104 ◽  
Author(s):  
Jan Timo Grotwinkel ◽  
Klemens Wild ◽  
Bernd Segnitz ◽  
Irmgard Sinning
Keyword(s):  
Ribosomal Rna ◽  
Protein Targeting ◽  
Rna Binding ◽  
Protein Translocation ◽  
Signal Recognition Particle ◽  
Structural Basis ◽  
Signal Recognition ◽  
Rna Remodeling ◽  
Srp Rna ◽  
Arginine Rich Motif

The signal recognition particle (SRP) is central to membrane protein targeting; SRP RNA is essential for SRP assembly, elongation arrest, and activation of SRP guanosine triphosphatases. In eukaryotes, SRP function relies on the SRP68-SRP72 heterodimer. We present the crystal structures of the RNA-binding domain of SRP68 (SRP68-RBD) alone and in complex with SRP RNA and SRP19. SRP68-RBD is a tetratricopeptide-like module that binds to a RNA three-way junction, bends the RNA, and inserts an α-helical arginine-rich motif (ARM) into the major groove. The ARM opens the conserved 5f RNA loop, which in ribosome-bound SRP establishes a contact to ribosomal RNA. Our data provide the structural basis for eukaryote-specific, SRP68-driven RNA remodeling required for protein translocation.

Structural basis of signal-sequence recognition by the signal recognition particle

2011 ◽  
Vol 18 (3) ◽  
pp. 389-391 ◽  
Author(s):  
Tobias Hainzl ◽  
Shenghua Huang ◽  
Gitte Meriläinen ◽  
Kristoffer Brännström ◽  
A Elisabeth Sauer-Eriksson
Keyword(s):  
Signal Sequence ◽  
Signal Recognition Particle ◽  
Structural Basis ◽  
Signal Recognition ◽  
Sequence Recognition

A signal recognition particle receptor gene from the early-diverging eukaryote, Giardia lamblia

1999 ◽  
Vol 98 (2) ◽  
pp. 253-264 ◽  
Author(s):  
Staffan G. Svärd ◽  
Colleen Rafferty ◽  
J.Michael McCaffery ◽  
Michael W. Smith ◽  
David S. Reiner ◽  
...  
Keyword(s):  
Giardia Lamblia ◽  
Receptor Gene ◽  
Signal Recognition Particle ◽  
Signal Recognition ◽  
Signal Recognition Particle Receptor
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