Faculty Opinions recommendation of c-Myc regulates mammalian body size by controlling cell number but not cell size.

2002 ◽  
Author(s):  
Laura Johnston
Keyword(s):  
Body Size ◽  
Cell Size ◽  
Cell Number

c-Myc regulates mammalian body size by controlling cell number but not cell size

Nature ◽  
2001 ◽  
Vol 414 (6865) ◽  
pp. 768-773 ◽  
Author(s):  
Andreas Trumpp ◽  
Yosef Refaeli ◽  
Thordur Oskarsson ◽  
Stephan Gasser ◽  
Mark Murphy ◽  
...  
Keyword(s):  
Body Size ◽  
Cell Size ◽  
Cell Number

scholarly journals DIFFERENT CELL SIZE AND CELL NUMBER CONTRIBUTION IN TWO NEWLY ESTABLISHED AND ONE ANCIENT BODY SIZE CLINE OF DROSOPHILA SUBOBSCURA

Evolution ◽  
2003 ◽  
Vol 57 (3) ◽  
pp. 566-573 ◽  
Author(s):  
Federico C. F. Calboli ◽  
George W. Gilchrist ◽  
Linda Partridge
Keyword(s):  
Body Size ◽  
Cell Size ◽  
Cell Number ◽  
Drosophila Subobscura

scholarly journals MalagasyConostigmus(Hymenoptera: Ceraphronoidea) and the secret of scutes

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2682 ◽  
Author(s):  
István Mikó ◽  
Carolyn Trietsch ◽  
Emily L. Sandall ◽  
Matthew Jon Yoder ◽  
Heather Hines ◽  
...  
Keyword(s):  
Body Size ◽  
Cell Size ◽  
Size Variation ◽  
Intraspecific Variability ◽  
Cell Number ◽  
Cellular Processes ◽  
Ontology Language ◽  
Diversity Gradient ◽  
New Information ◽  
First Time

We revise the genusConostigmus Dahlbom1858 occurring in Madagascar, based on data from more specimens than were examined for the latest world revision of the genus. Our results yield new information about intraspecific variability and the nature of the atypical latitudinal diversity gradient (LDG) observed in Ceraphronoidea. We also investigate cellular processes that underlie body size polyphenism, by utilizing the correspondence between epidermal cells and scutes, polygonal units of leather-like microsculpture. Our results reveal that body size polyphenism in Megaspilidae is most likely related to cell number and not cell size variation, and that cell size differs between epithelial fields of the head and that of the mesosoma. Three species,Conostigmus ballescoracasDessart, 1997,C. babaiaxDessart, 1996 andC. longulusDessart, 1997, are redescribed. Females ofC. longulusare described for the first time, as are nine new species:C. bucephalusMikó and Trietsch sp. nov.,C. clavatusMikó and Trietsch sp. nov.,C. fianarantsoaensisMikó and Trietsch sp. nov.,C. lucidusMikó and Trietsch sp. nov.,C. macrocupula, Mikó and Trietsch sp. nov.,C. madagascariensisMikó and Trietsch sp. nov.,C. missyhazenaeMikó and Trietsch sp. nov.,C. pseudobabaiaxMikó and Trietsch sp. nov., andC. toliaraensisMikó and Trietsch sp. nov. A fully illustrated identification key forMalagasy Conostigmusspecies and a Web Ontology Language (OWL) representation of the taxonomic treatment, including specimen data, nomenclature, and phenotype descriptions, in both natural and formal languages, are provided.

scholarly journals Environmental effects on body size variation in Drosophila melanogaster and its cellular basis

1997 ◽  
Vol 70 (1) ◽  
pp. 35-43 ◽  
Author(s):  
G. H. DE MOED ◽  
G. DE JONG ◽  
W. SCHARLOO
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Variation ◽  
Body Size ◽  
Cell Size ◽  
Wing Length ◽  
Size Variation ◽  
Cell Number ◽  
Food Level ◽  
Mean Size ◽  
Food Conditions

Eight isofemale lines of Drosophila melanogaster were raised at four temperatures and at four yeast concentrations in their food. Temperature and food show a significant interaction in determining wing length and thorax length, affecting mean size per line and genetic variation between lines. The combination of low temperature and poor food conditions leads to a sharp increase in the genetic variation over lines of both body size characters. The increase in genetic variation in wing length under less favourable conditions is due to an increase in genetic variation of both cell size and cell number. Changes in wing area in response to both temperature and food level follow a common cell size/cell number trajectory. Changes in wing size are obtained by line-specific changes in the cellular composition of the wing, rather than by changes specific for the environmental factor.

scholarly journals Reduced beta cell number rather than size is a major contributor to beta cell loss in type 2 diabetes

Diabetologia ◽  
2021 ◽  
Author(s):  
Hironobu Sasaki ◽  
Yoshifumi Saisho ◽  
Jun Inaishi ◽  
Yuusuke Watanabe ◽  
Tami Tsuchiya ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Beta Cell ◽  
Cell Size ◽  
Cell Mass ◽  
Cell Number ◽  
Relative Reduction ◽  
Major Contributor ◽  
Islet Morphology ◽  
The Impact

Abstract Aims/hypothesis Type 2 diabetes is characterised by reduced beta cell mass (BCM). However, it remains uncertain whether the reduction in BCM in type 2 diabetes is due to a decrease in size or number of beta cells. Our aim was to examine the impact of beta cell size and number on islet morphology in humans with and without type 2 diabetes. Methods Pancreas samples were obtained from 64 Japanese adults with (n = 26) and without (n = 38) type 2 diabetes who underwent pancreatectomy. Using pancreatic tissues stained for insulin, we estimated beta cell size based on beta cell diameter. Beta cell number was estimated from the product of fractional beta cell area and pancreas volume divided by beta cell size. The associations of beta cell size and number with islet morphology and metabolic status were examined. Results Both beta cell size (548.7 ± 58.5 vs 606.7 ± 65.0 μm3, p < 0.01) and number (5.10 × 108 ± 2.35 × 108 vs 8.16 × 108 ± 4.27 × 108, p < 0.01) were decreased in participants with type 2 diabetes compared with those without diabetes, with the relative reduction in beta cell number (37%) being greater than for beta cell size (10%). Beta cell number but not size was positively correlated with BCM in participants with and without type 2 diabetes (r = 0.97 and r = 0.98, both p < 0.01) and negatively correlated with HbA1c (r = −0.45, p < 0.01). Conclusions/interpretation Both beta cell size and number were reduced in participants with type 2 diabetes, with the relative reduction in beta cell number being greater. Decrease in beta cell number appears to be a major contributor to reduced BCM in type 2 diabetes. Graphical abstract

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