Faculty Opinions recommendation of Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression.

2003 ◽  
Author(s):  
Evelyn Jabri
Keyword(s):  
Mental Retardation ◽  
Messenger Rna ◽  
Fragile X ◽  
Cytoplasmic Granules ◽  
Translation Repression ◽  
Fragile X Mental Retardation ◽  
Mental Retardation Protein

scholarly journals Hypothesis: A Role for Fragile X Mental Retardation Protein in Mediating and Relieving MicroRNA-Guided Translational Repression?

2006 ◽  
Vol 2006 ◽  
pp. 1-7 ◽  
Author(s):  
Isabelle Plante ◽  
Patrick Provost
Keyword(s):  
Mental Retardation ◽  
Messenger Rna ◽  
Mammalian Cells ◽  
Fragile X ◽  
Strand Exchange ◽  
Translational Repression ◽  
Fragile X Mental Retardation ◽  
Mental Retardation Protein ◽  
Cellular Signal ◽  
Reverse Strand

MicroRNA (miRNA)-guided messenger RNA (mRNA) translational repression is believed to be mediated by effector miRNA-containing ribonucleoprotein (miRNP) complexes harboring fragile X mental retardation protein (FMRP). Recent studies documented the nucleic acid chaperone properties of FMRP and characterized its role and importance in RNA silencing in mammalian cells. We propose a model in which FMRP could facilitate miRNA assembly on target mRNAs in a process involving recognition of G quartet structures. Functioning within a duplex miRNP, FMRP may also mediate mRNA targeting through a strand exchange mechanism, in which the miRNA*of the duplex is swapped for the mRNA. Furthermore, FMRP may contribute to the relief of miRNA-guided mRNA repression through a reverse strand exchange reaction, possibly initiated by a specific cellular signal, that would liberate the mRNA for translation. Suboptimal utilization of miRNAs may thus account for some of themolecular defects in patients with the fragile X syndrome.

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