Faculty Opinions recommendation of Hox control of organ size by regulation of morphogen production and mobility.

Author(s):  
Carl Thummel
Keyword(s):  
Author(s):  
Emanuele Trovalusci ◽  
Marco Gasparella ◽  
Cristina Pizzato ◽  
Paola Midrio

AbstractThe laparoscopic splenectomy in pediatric patients is performed worldwide but often the disproportion between size of patients and size of organs requires an extra laparotomic access for spleen removal. The aim of the present study was to evaluate the safety and effectiveness of the Alexis® system to retrieve the spleen without additional laparotomic access. The charts of all patients who underwent splenectomy at our center during the last 5 years were retrieved. In all the cases the Alexis® system was placed in the umbilicus, thru which a 10 mm camera was inserted. Three additional 5 mm standard trocars were inserted. Seven patients, affected by spherocytosis (3), epidermoid cyst (2), idiopathic thrombocytopenic purpura (2) and thalassemia (1), underwent laparoscopic splenectomy at a median age of 10 years (range: 8–17). Median patients’ weight was 32.5 kg (range: 25–71) and spleen size 15 cm (11–18). In all the cases, upon removal of the camera, the retrieval bag was inserted thru the umbilicus under direct view, the spleen retrieved, morcellated, and removed. No conversion nor enlargement of one of the ports nor an extra laparotomic access were required. The patients were discharged on the fifth post-operative day and the cosmetic results were excellent. Removal of the spleen can be safely performed without any additional laparotomy thru the Alexis® system placed in the umbilicus. This system is effective also in case of major patient/organ size disproportion and the final cosmetic aspect is excellent.


2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Nian Liu ◽  
Lili Tu ◽  
Lichen Wang ◽  
Haiyan Hu ◽  
Jiao Xu ◽  
...  

2020 ◽  
Vol 64 (4-5-6) ◽  
pp. 299-318
Author(s):  
Carmen M.A. Coelho

The regulation of growth and the determination of organ-size in animals is an area of research that has received much attention during the past two and a half decades. Classic regeneration and cell-competition studies performed during the last century suggested that for size to be determined, organ-size is sensed and this sense of size feeds back into the growth control mechanism such that growth stops at the “correct” size. Recent work using Drosophila imaginal discs as a system has provided a particularly detailed cellular and molecular understanding of growth. Yet, a clear mechanistic basis for size-sensing has not emerged. I re-examine these studies from a different perspective and ask whether there is scope for alternate modes of size control in which size does not need to be sensed.


Nature ◽  
2007 ◽  
Vol 445 (7130) ◽  
pp. 886-891 ◽  
Author(s):  
Ben Z. Stanger ◽  
Akemi J. Tanaka ◽  
Douglas A. Melton
Keyword(s):  

Nature ◽  
2016 ◽  
Vol 530 (7590) ◽  
pp. 344-348 ◽  
Author(s):  
Bruno Hudry ◽  
Sanjay Khadayate ◽  
Irene Miguel-Aliaga

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