Faculty Opinions recommendation of The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells.

2009 ◽  
Author(s):  
Peter Downes ◽  
Nicholas Leslie
Keyword(s):  
Tumor Suppressor ◽  
Epithelial Cells ◽  
Epithelial Mesenchymal Transition ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Mesenchymal Transition ◽  
Group Protein ◽  
Nasopharyngeal Epithelial

scholarly journals Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity

2021 ◽  
Vol 7 (1) ◽  
pp. 00254-2020
Author(s):  
Jonathan O'Loughlin ◽  
Robert J. Hall ◽  
Sangita Bhaker ◽  
Michael A. Portelli ◽  
Amanda Henry ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Epithelial Cells ◽  
Epithelial Mesenchymal Transition ◽  
Cell Attachment ◽  
Bronchial Epithelial Cells ◽  
Polycomb Group ◽  
Proliferative Potential ◽  
Polycomb Group Protein ◽  
Bronchial Epithelial ◽  
Mesenchymal Transition

Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs) isolated from patients. Increased expression of the polycomb group protein BMI-1 extends the lifespan of HBECs while maintaining cell context plasticity. Herein we aimed to assess how BMI-1 expression impacted cellular functions and global mRNA expression. HBECs from six donors were transduced with lentivirus containing BMI-1 and cells were characterised, including by RNA sequencing and impedance measurement. BMI-1-expressing HBECs (B-HBECs) have a proliferative advantage and show comparable in vitro properties to low passage primary HBECs, including cell attachment/spreading and barrier formation. The B-HBEC mRNA signature was modestly different to HBECs, with only 293 genes differentially expressed (5% false discovery rate). Genes linked to epithelial mesenchymal transition and cell cycle were enriched in B-HBECs. We investigated the expression of genes implicated in asthma from genetic and expression studies and found that 97.6% of genes remained unaltered. We have shown that increased BMI-1 expression in HBECs delays lung epithelial cell senescence by promoting cell cycle progression and highlighted the flexible utility for B-HBECs as an important platform for studying airway epithelial mechanisms.

scholarly journals The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2

Oncogene ◽  
2007 ◽  
Vol 26 (31) ◽  
pp. 4590-4595 ◽  
Author(s):  
L Beke ◽  
M Nuytten ◽  
A Van Eynde ◽  
M Beullens ◽  
M Bollen
Keyword(s):  
Tumor Suppressor ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Gene Encoding ◽  
Group Protein ◽  
Prostatic Tumor

scholarly journals The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells

Neoplasia ◽  
2005 ◽  
Vol 7 (11) ◽  
pp. 1011-1019 ◽  
Author(s):  
Michael Zeidler ◽  
Sooryanarayana Varambally ◽  
Qi Cao ◽  
Arul M. Chinnaiyan ◽  
David O. Ferguson ◽  
...  
Keyword(s):  
Dna Repair ◽  
Epithelial Cells ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Breast Epithelial Cells ◽  
Group Protein ◽  
Breast Epithelial

Epigenetic Repression of SATB1 by Polycomb Group Protein EZH2 in Epithelial Cells

2010 ◽  
Vol 25 (4) ◽  
pp. 199-205 ◽  
Author(s):  
Lei Li ◽  
Lu Lu ◽  
Xiang Lü ◽  
Xue-song Wu ◽  
De-pei Liu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Group Protein ◽  
Epigenetic Repression

scholarly journals The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells

Oncotarget ◽  
2014 ◽  
Vol 5 (8) ◽  
pp. 2065-2076 ◽  
Author(s):  
Almudena Bosch ◽  
Konstantina Panoutsopoulou ◽  
Josep Maria Corominas ◽  
Ramón Gimeno ◽  
Gema Moreno-Bueno ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Steady State ◽  
Breast Carcinoma ◽  
Epithelial Cells ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Ductal Breast Carcinoma ◽  
Group Protein ◽  
Steady State Levels

scholarly journals The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2

2009 ◽  
Vol 69 (6) ◽  
pp. 2623-2629 ◽  
Author(s):  
Jeffrey M. Friedman ◽  
Gangning Liang ◽  
Chun-Chi Liu ◽  
Erika M. Wolff ◽  
Yvonne C. Tsai ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Putative Tumor Suppressor ◽  
Group Protein
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