Faculty Opinions recommendation of Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice.

2011 ◽  
Author(s):  
Juan Bernal
Keyword(s):  
Skeletal Muscle ◽  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Alpha ◽  
Deficient Mice

scholarly journals Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142400 ◽  
Author(s):  
Hideyuki Matsunaga ◽  
Shigekazu Sasaki ◽  
Shingo Suzuki ◽  
Akio Matsushita ◽  
Hirotoshi Nakamura ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Essential Role ◽  
Thyroid Hormone Receptor ◽  
Negative Regulation

scholarly journals Thyroid Hormone Receptor Alpha is Essential to Maintain the Satellite Cell Niche During Skeletal Muscle Injury and Sarcopenia of Aging

Thyroid ◽  
2017 ◽  
Vol 27 (10) ◽  
pp. 1316-1322 ◽  
Author(s):  
Anna Milanesi ◽  
Jang-Won Lee ◽  
An Yang ◽  
Yan-Yun Liu ◽  
Sargis Sedrakyan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Thyroid Hormone ◽  
Satellite Cell ◽  
Hormone Receptor ◽  
Muscle Injury ◽  
Thyroid Hormone Receptor ◽  
Skeletal Muscle Injury ◽  
Receptor Alpha ◽  
Satellite Cell Niche ◽  
Cell Niche

scholarly journals SAT-560 Role of COUP-TFII and Thyroid Hormone Receptor α in Skeletal Muscle Loss

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Paola Aguiari ◽  
Yan-Yun Liu ◽  
Sheue-Yann Cheng ◽  
Laura Perin ◽  
Gregory Brent ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Muscle Loss ◽  
Skeletal Muscle Loss ◽  
Thyroid Hormone Receptor Α

Isometric force and endurance in soleus muscle of thyroid hormone receptor-α1- or -β-deficient mice

2000 ◽  
Vol 278 (3) ◽  
pp. R598-R603 ◽  
Author(s):  
Catarina Johansson ◽  
Jan Lännergren ◽  
Per-Kristian Lunde ◽  
Björn Vennström ◽  
Peter Thorén ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Isometric Force ◽  
Relaxation Times ◽  
Wild Type ◽  
Skeletal Muscle Function ◽  
Contraction And Relaxation ◽  
Deficient Mice

The specific role of each subtype of thyroid hormone receptor (TR) on skeletal muscle function is unclear. We have therefore studied kinetics of isometric twitches and tetani as well as fatigue resistance in isolated soleus muscles of R-α1- or -β-deficient mice. The results show 20–40% longer contraction and relaxation times of twitches and tetani in soleus muscles from TR-α1-deficient mice compared with their wild-type controls. TR-β-deficient mice, which have high thyroid hormone levels, were less fatigue resistant than their wild-type controls, but contraction and relaxation times were not different. Western blot analyses showed a reduced concentration of the fast-type sarcoplasmic reticulum Ca2+-ATPase (SERCa1) in TR-α1-deficient mice, but no changes were observed in TR-β-deficient mice compared with their respective controls. We conclude that in skeletal muscle, both TR-α1 and TR-β are required to get a normal thyroid hormone response.

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