Faculty Opinions recommendation of The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.

2010 ◽  
Author(s):  
Peter Downes ◽  
Nicholas Leslie
Keyword(s):  
Growth Factor ◽  
Tumor Suppressor ◽  
Negative Regulation ◽  
Regulatory Subunit ◽  
Growth Factor Signaling ◽  
Phosphoinositide 3 Kinase ◽  
Regulation Of Growth

scholarly journals The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

2010 ◽  
Vol 70 (13) ◽  
pp. 5305-5315 ◽  
Author(s):  
Cullen M. Taniguchi ◽  
Jonathon Winnay ◽  
Tatsuya Kondo ◽  
Roderick T. Bronson ◽  
Alexander R. Guimaraes ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Suppressor ◽  
Negative Regulation ◽  
Regulatory Subunit ◽  
Growth Factor Signaling ◽  
Phosphoinositide 3 Kinase ◽  
Regulation Of Growth

scholarly journals Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival

2002 ◽  
Vol 22 (3) ◽  
pp. 965-977 ◽  
Author(s):  
Kohjiro Ueki ◽  
David A. Fruman ◽  
Saskia M. Brachmann ◽  
Yu-Hua Tseng ◽  
Lewis C. Cantley ◽  
...  
Keyword(s):  
Growth Factor ◽  
Insulin Signaling ◽  
Regulatory Subunit ◽  
Central Component ◽  
Growth Factor Signaling ◽  
Wild Type ◽  
Catalytic Subunits ◽  
Phosphoinositide 3 Kinase ◽  
Molecular Balance ◽  
Kinase Pathway

ABSTRACT Class Ia phosphoinositide (PI) 3-kinase is a central component in growth factor signaling and is comprised of a p110 catalytic subunit and a regulatory subunit, the most common family of which is derived from the p85α gene (Pik3r1). Optimal signaling through the PI 3-kinase pathway depends on a critical molecular balance between the regulatory and catalytic subunits. In wild-type cells, the p85 subunit is more abundant than p110, leading to competition between the p85 monomer and the p85-p110 dimer and ineffective signaling. Heterozygous disruption of Pik3r1 results in increased Akt activity and decreased apoptosis by insulin-like growth factor 1 (IGF-1) through up-regulated phosphatidylinositol (3,4,5)-triphosphate production. Complete depletion of p85α, on the other hand, results in significantly increased apoptosis due to reduced PI 3-kinase-dependent signaling. Thus, a reduction in p85α represents a novel therapeutic target for enhancing IGF-1/insulin signaling, prolongation of cell survival, and protection against apoptosis.

scholarly journals Extracellular regulation of growth factor signaling by fibrillin microfibrils

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Lynn Sakai ◽  
Gerhard Sengle ◽  
Noe L. Charbonneau ◽  
Valerie M. Carlberg
Keyword(s):  
Growth Factor ◽  
Growth Factor Signaling ◽  
Regulation Of Growth

scholarly journals Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling

PLoS Genetics ◽  
2011 ◽  
Vol 7 (11) ◽  
pp. e1002363 ◽  
Author(s):  
Ashish Lal ◽  
Marshall P. Thomas ◽  
Gabriel Altschuler ◽  
Francisco Navarro ◽  
Elizabeth O'Day ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Suppressor ◽  
Growth Factor Signaling
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