Faculty Opinions recommendation of Structural basis for the transcriptional regulation of membrane lipid homeostasis.

2010 ◽  
Author(s):  
Roy Lancaster ◽  
Florian Müller
Keyword(s):  
Transcriptional Regulation ◽  
Membrane Lipid ◽  
Lipid Homeostasis ◽  
Structural Basis

scholarly journals Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus

2013 ◽  
Vol 9 (1) ◽  
pp. e1003108 ◽  
Author(s):  
Daniela Albanesi ◽  
Georgina Reh ◽  
Marcelo E. Guerin ◽  
Francis Schaeffer ◽  
Michel Debarbouille ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Transcriptional Regulation ◽  
Membrane Lipid ◽  
Lipid Homeostasis ◽  
Structural Basis ◽  
Feed Forward

scholarly journals Structural basis for the transcriptional regulation of membrane lipid homeostasis

2010 ◽  
Vol 17 (8) ◽  
pp. 971-975 ◽  
Author(s):  
Darcie J Miller ◽  
Yong-Mei Zhang ◽  
Chitra Subramanian ◽  
Charles O Rock ◽  
Stephen W White
Keyword(s):  
Transcriptional Regulation ◽  
Membrane Lipid ◽  
Lipid Homeostasis ◽  
Structural Basis

scholarly journals Transcriptional Regulation of Membrane Lipid Homeostasis in Escherichia coli

2009 ◽  
Vol 284 (50) ◽  
pp. 34880-34888 ◽  
Author(s):  
Kun Zhu ◽  
Yong-Mei Zhang ◽  
Charles O. Rock
Keyword(s):  
Escherichia Coli ◽  
Transcriptional Regulation ◽  
Membrane Lipid ◽  
Lipid Homeostasis

scholarly journals Lipid Acyl Chain Remodeling in Yeast

2015 ◽  
Vol 8s1 ◽  
pp. LPI.S31780 ◽  
Author(s):  
Mike F. Renne ◽  
Xue Bao ◽  
Cedric H. De Smet ◽  
Anton I. P. M. De Kroon
Keyword(s):  
Intracellular Transport ◽  
De Novo ◽  
Acyl Chain ◽  
Model Organism ◽  
Lipid Synthesis ◽  
Membrane Lipid ◽  
Lipid Homeostasis ◽  
Synthetic Process ◽  
Acyl Chains ◽  
Phospholipid Acyl Chain

Membrane lipid homeostasis is maintained by de novo synthesis, intracellular transport, remodeling, and degradation of lipid molecules. Glycerophospholipids, the most abundant structural component of eukaryotic membranes, are subject to acyl chain remodeling, which is defined as the post-synthetic process in which one or both acyl chains are exchanged. Here, we review studies addressing acyl chain remodeling of membrane glycerophospholipids in Saccharomyces cerevisiae, a model organism that has been successfully used to investigate lipid synthesis and its regulation. Experimental evidence for the occurrence of phospholipid acyl chain exchange in cardiolipin, phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine is summarized, including methods and tools that have been used for detecting remodeling. Progress in the identification of the enzymes involved is reported, and putative functions of acyl chain remodeling in yeast are discussed.

scholarly journals First person – Wei Sheng Yap

2020 ◽  
Vol 133 (21) ◽  
pp. jcs256016
Keyword(s):  
Biological Sciences ◽  
Membrane Lipid ◽  
Early Career ◽  
Lipid Homeostasis ◽  
First Person ◽  
Early Career Researchers ◽  
Technological University ◽  
Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Wei Sheng Yap is first author on ‘The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis’, published in JCS. Wei Sheng works in the lab of Guillaume Thibault in the School of Biological Sciences, Nanyang Technological University, Singapore, studying the interplay between the proteostasis network and lipid homeostasis.

scholarly journals Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

Science ◽  
2019 ◽  
Vol 363 (6430) ◽  
pp. eaav9334 ◽  
Author(s):  
Ying Yin ◽  
Son C. Le ◽  
Allen L. Hsu ◽  
Mario J. Borgnia ◽  
Huanghe Yang ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Structural Information ◽  
Receptor Potential ◽  
Membrane Lipid ◽  
Structural Basis ◽  
Trpm8 Channel ◽  
Allosteric Coupling ◽  
Transient Receptor Potential Melastatin ◽  
Lipid Sensing ◽  
Transient Receptor

Transient receptor potential melastatin member 8 (TRPM8) is a calcium ion (Ca2+)–permeable cation channel that serves as the primary cold and menthol sensor in humans. Activation of TRPM8 by cooling compounds relies on allosteric actions of agonist and membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), but lack of structural information has thus far precluded a mechanistic understanding of ligand and lipid sensing by TRPM8. Using cryo–electron microscopy, we determined the structures of TRPM8 in complex with the synthetic cooling compound icilin, PIP2, and Ca2+, as well as in complex with the menthol analog WS-12 and PIP2. Our structures reveal the binding sites for cooling agonists and PIP2in TRPM8. Notably, PIP2binds to TRPM8 in two different modes, which illustrate the mechanism of allosteric coupling between PIP2and agonists. This study provides a platform for understanding the molecular mechanism of TRPM8 activation by cooling agents.

scholarly journals The Role of Diglycosyl Lipids in Photosynthesis and Membrane Lipid Homeostasis in Arabidopsis

2009 ◽  
Vol 150 (3) ◽  
pp. 1147-1159 ◽  
Author(s):  
Georg Hölzl ◽  
Sandra Witt ◽  
Nicole Gaude ◽  
Michael Melzer ◽  
Mark Aurel Schöttler ◽  
...  
Keyword(s):  
Membrane Lipid ◽  
Lipid Homeostasis

scholarly journals Understanding the role of lipids and lipoproteins in development

Development ◽  
2020 ◽  
Vol 147 (24) ◽  
pp. dev186411 ◽  
Author(s):  
Wilhelm Palm ◽  
Jonathan Rodenfels
Keyword(s):  
Fruit Fly ◽  
Membrane Lipid ◽  
Lipid Homeostasis ◽  
Hedgehog Signalling ◽  
Animal Development ◽  
Lipid Species ◽  
Hedgehog Signalling Pathway ◽  
Living Organisms ◽  
Lipids And Lipoproteins

ABSTRACTLipids exert diverse functions in living organisms. They form cellular membranes, store and transport energy and play signalling roles. Some lipid species function in all of these processes, making them ideal candidates to coordinate metabolism with cellular homeostasis and animal development. This theme was central to Suzanne Eaton's research in the fruit fly, Drosophila. Here, we discuss her work on membrane lipid homeostasis in changing environments and on functions for lipids in the Hedgehog signalling pathway. We further highlight lipoproteins as inter-organ carriers of lipids and lipid-linked morphogens, which communicate dietary and developmental signals throughout the organism.

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