Membrane Lipid Homeostasis

2004 ◽  
pp. 317-357 ◽  
Author(s):  
Claude Wolf ◽  
Peter J. Quinn
Keyword(s):  
Membrane Lipid ◽  
Lipid Homeostasis

scholarly journals Lipid Acyl Chain Remodeling in Yeast

2015 ◽  
Vol 8s1 ◽  
pp. LPI.S31780 ◽  
Author(s):  
Mike F. Renne ◽  
Xue Bao ◽  
Cedric H. De Smet ◽  
Anton I. P. M. De Kroon
Keyword(s):  
Intracellular Transport ◽  
De Novo ◽  
Acyl Chain ◽  
Model Organism ◽  
Lipid Synthesis ◽  
Membrane Lipid ◽  
Lipid Homeostasis ◽  
Synthetic Process ◽  
Acyl Chains ◽  
Phospholipid Acyl Chain

Membrane lipid homeostasis is maintained by de novo synthesis, intracellular transport, remodeling, and degradation of lipid molecules. Glycerophospholipids, the most abundant structural component of eukaryotic membranes, are subject to acyl chain remodeling, which is defined as the post-synthetic process in which one or both acyl chains are exchanged. Here, we review studies addressing acyl chain remodeling of membrane glycerophospholipids in Saccharomyces cerevisiae, a model organism that has been successfully used to investigate lipid synthesis and its regulation. Experimental evidence for the occurrence of phospholipid acyl chain exchange in cardiolipin, phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine is summarized, including methods and tools that have been used for detecting remodeling. Progress in the identification of the enzymes involved is reported, and putative functions of acyl chain remodeling in yeast are discussed.

scholarly journals First person – Wei Sheng Yap

2020 ◽  
Vol 133 (21) ◽  
pp. jcs256016
Keyword(s):  
Biological Sciences ◽  
Membrane Lipid ◽  
Early Career ◽  
Lipid Homeostasis ◽  
First Person ◽  
Early Career Researchers ◽  
Technological University ◽  
Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Wei Sheng Yap is first author on ‘The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis’, published in JCS. Wei Sheng works in the lab of Guillaume Thibault in the School of Biological Sciences, Nanyang Technological University, Singapore, studying the interplay between the proteostasis network and lipid homeostasis.

scholarly journals The Role of Diglycosyl Lipids in Photosynthesis and Membrane Lipid Homeostasis in Arabidopsis

2009 ◽  
Vol 150 (3) ◽  
pp. 1147-1159 ◽  
Author(s):  
Georg Hölzl ◽  
Sandra Witt ◽  
Nicole Gaude ◽  
Michael Melzer ◽  
Mark Aurel Schöttler ◽  
...  
Keyword(s):  
Membrane Lipid ◽  
Lipid Homeostasis

scholarly journals Understanding the role of lipids and lipoproteins in development

Development ◽  
2020 ◽  
Vol 147 (24) ◽  
pp. dev186411 ◽  
Author(s):  
Wilhelm Palm ◽  
Jonathan Rodenfels
Keyword(s):  
Fruit Fly ◽  
Membrane Lipid ◽  
Lipid Homeostasis ◽  
Hedgehog Signalling ◽  
Animal Development ◽  
Lipid Species ◽  
Hedgehog Signalling Pathway ◽  
Living Organisms ◽  
Lipids And Lipoproteins

ABSTRACTLipids exert diverse functions in living organisms. They form cellular membranes, store and transport energy and play signalling roles. Some lipid species function in all of these processes, making them ideal candidates to coordinate metabolism with cellular homeostasis and animal development. This theme was central to Suzanne Eaton's research in the fruit fly, Drosophila. Here, we discuss her work on membrane lipid homeostasis in changing environments and on functions for lipids in the Hedgehog signalling pathway. We further highlight lipoproteins as inter-organ carriers of lipids and lipid-linked morphogens, which communicate dietary and developmental signals throughout the organism.

scholarly journals Diverse Chemical Compounds Target Plasmodium falciparum Plasma Membrane Lipid Homeostasis

2019 ◽  
Vol 5 (4) ◽  
pp. 550-558 ◽  
Author(s):  
Suyash Bhatnagar ◽  
Sezin Nicklas ◽  
Joanne M. Morrisey ◽  
Daniel E. Goldberg ◽  
Akhil B. Vaidya
Keyword(s):  
Plasmodium Falciparum ◽  
Plasma Membrane ◽  
Chemical Compounds ◽  
Membrane Lipid ◽  
Lipid Homeostasis ◽  
Plasma Membrane Lipid

scholarly journals The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis

2020 ◽  
Vol 133 (21) ◽  
pp. jcs248526 ◽  
Author(s):  
Wei Sheng Yap ◽  
Peter Shyu ◽  
Maria Laura Gaspar ◽  
Stephen A. Jesch ◽  
Charlie Marvalim ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Endoplasmic Reticulum ◽  
Lipid Droplets ◽  
Membrane Lipid ◽  
Model System ◽  
Lipid Homeostasis ◽  
Compensatory Mechanism ◽  
Unfolded Protein ◽  
Protein Response

ABSTRACTLipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage-inducing transmembrane (FIT; also known as FITM) family induces LD formation. Here, we establish a model system to study the role of the Saccharomyces cerevisiae FIT homologues (ScFIT), SCS3 and YFT2, in the proteostasis and stress response pathways. While LD biogenesis and basal endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) remain unaltered in ScFIT mutants, SCS3 was found to be essential for proper stress-induced UPR activation and for viability in the absence of the sole yeast UPR transducer IRE1. Owing to not having a functional UPR, cells with mutated SCS3 exhibited an accumulation of triacylglycerol within the ER along with aberrant LD morphology, suggesting that there is a UPR-dependent compensatory mechanism that acts to mitigate lack of SCS3. Additionally, SCS3 was necessary to maintain phospholipid homeostasis. Strikingly, global protein ubiquitylation and the turnover of both ER and cytoplasmic misfolded proteins is impaired in ScFITΔ cells, while a screen for interacting partners of Scs3 identifies components of the proteostatic machinery as putative targets. Together, our data support a model where ScFITs play an important role in lipid metabolism and proteostasis beyond their defined roles in LD biogenesis.This article has an associated First Person interview with the first author of the paper.

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