Faculty Opinions recommendation of The prevalence of thyroid disease in patients with vitiligo: a systematic review.

Background Sjogren’s syndrome (SS) is a chronic autoimmune epithelitis characterized by disruption of epithelial cells, ensuing lymphoplasmocytic infiltration of exocrine glands, and subsequent dryness of the mouth and eyes. Individuals with SS are more likely to have the thyroid disease. However, this association remains controversial. This meta-analysis aimed to evaluate the risk of thyroid disease in patients with SS. Methods We performed this systematic review by searching both English and Chinese literature databases. Random- or fixed-effects models were used to summarize the association between thyroid disease and SS. The results were subjected to meta-analysis with odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Results The eight articles in this meta-analysis included 988 SS cases and 2,884 controls. Overall, the risk of thyroid disease in patients with SS was significantly increased compared with controls (OR, 3.29; 95% CI [2.08–5.21]). The risk of autoimmune thyroid disease (AITD) and non-AITD were also higher in patients with SS than in controls (OR, 3.48; 95% CI [1.59–7.63]; and OR, 2.90; 95% CI [1.51–5.57], respectively). Conclusions To the best of our knowledge, this systematic review is the first to demonstrate that the risk of thyroid disease was increased in SS compared to controls, suggesting that SS patients should be screened for thyroid disease.

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Systematic Review and Meta-analysis of Robotic vs Conventional Thyroidectomy Approaches for Thyroid Disease

Otolaryngology ◽

10.1177/0194599814521779 ◽

2014 ◽

Vol 150 (4) ◽

pp. 520-532 ◽

Cited By ~ 66

Author(s):

Gordon H. Sun ◽

Lilia Peress ◽

Melissa A. Pynnonen

Keyword(s):

Systematic Review ◽

Thyroid Disease ◽

Meta Analysis ◽

Conventional Thyroidectomy

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Increased Incidence of Thyroid Disease in Patients with Alopecia Areata: A Systematic Review and Meta-Analysis

Dermatology ◽

10.1159/000502025 ◽

2019 ◽

Vol 236 (3) ◽

pp. 251-254 ◽

Cited By ~ 1

Author(s):

Caihong Xin ◽

Xin Sun ◽

Li Lu ◽

Rong Yang ◽

Ling Shan ◽

...

Keyword(s):

Systematic Review ◽

Confidence Intervals ◽

Hair Loss ◽

Alopecia Areata ◽

Thyroid Disease ◽

Fixed Effects ◽

Chinese Literature ◽

Meta Analysis ◽

Fixed Effects Models ◽

Immune Mediated

Background: Alopecia areata (AA) is a common, clinically heterogeneous, immune-mediated, nonscarring hair loss disease with a pathogenesis that is not fully understood. The prevalence of thyroid disease is likely increased among individuals with AA. However, this association remains controversial. Objective: To evaluate the risk of thyroid disease in patients with AA. Methods: We performed a systematic review by searching both English and Chinese literature databases. Random- or fixed-effects models were used to summarize the association between thyroid disease and AA. Results: In total, 17 articles were included in this meta-analysis, with 2,850 AA cases and 4,667 controls. Overall, the prevalence of thyroid disease in patients with AA was significantly increased compared with that in controls (odds ratios 3.66, 95% confidence intervals 2.90–4.61). Conclusions: The results suggest that AA patients should be screened for thyroid disease.

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Hidradenitis Suppurativa and Thyroid Disease: Systematic Review and Meta-Analysis

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475419874411 ◽

2019 ◽

Vol 24 (1) ◽

pp. 23-27

Author(s):

Kevin Phan ◽

Ya Ruth Huo ◽

Olivia Charlton ◽

Saxon D. Smith

Keyword(s):

Systematic Review ◽

Thyroid Disease ◽

Hidradenitis Suppurativa ◽

Meta Analysis ◽

Pooled Analysis ◽

Case Control ◽

Chronic Inflammatory Disease ◽

Case Control Studies ◽

Clinical Endpoints ◽

Potential Association

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful nodules, sinus tracts, and significant scarring. Although the pathogenesis of this disease is not well established, there is increasing evidence to suggest that it is an immune-mediated disorder. Previous studies have suggested a relationship between HS and thyroid disease, which is also driven by an autoimmune process. We sought to assess whether an association exists between HS and thyroid disease. Objectives: To determine whether HS is associated with thyroid disease via meta-analysis of case-control studies. Methods: A systematic review and meta-analysis was performed according to recommended PRISMA guidelines. Electronic searches were performed using 6 electronic databases from their inception until August 2018. Data were extracted and analyzed according to predefined clinical endpoints. Odds ratio (OR) was used as the summary effect size. Results: We identified 5 case-controls studies included for meta-analysis. There were a total of 36 103 HS cases compared with 170 517 control cases. We found a significant association between HS and thyroid disease (OR 1.36, 95% CI 1.13-1.64, I 2 = 78%, P = .001). Conclusions: This pooled analysis of existing case-control studies to date supports an association between HS and any thyroid disease. Clinicians treating patients with HS should be aware of this potential association with thyroid disease.

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