Faculty Opinions recommendation of Photosensitizing agents and the risk of non-melanoma skin cancer: a population-based case-control study.

Author(s):  
Iris Zalaudek ◽  
Aimilios Lallas
2013 ◽  
Vol 133 (8) ◽  
pp. 1950-1955 ◽  
Author(s):  
Sarah N. Robinson ◽  
Michael S. Zens ◽  
Ann E. Perry ◽  
Steven K. Spencer ◽  
Eric J. Duell ◽  
...  

1996 ◽  
Vol 46 (3) ◽  
pp. 186-196 ◽  
Author(s):  
J. F. Gamble ◽  
S. E. Lerman ◽  
W. R. Holder ◽  
M. J. Nicolich ◽  
C. M. Yarborough

2011 ◽  
Vol 23 (2) ◽  
pp. 245-254 ◽  
Author(s):  
Dana E. Rollison ◽  
Michelle R. Iannacone ◽  
Jane L. Messina ◽  
L. Frank Glass ◽  
Anna R. Giuliano ◽  
...  

2020 ◽  
Vol 9 (12) ◽  
pp. 3819
Author(s):  
Carolina Morgado-Águila ◽  
Purificación Rey-Sánchez ◽  
Guadalupe Gil-Fernández ◽  
María Carmen Costa-Fernández ◽  
Francisco José Rodríguez-Velasco

Exposure to sunlight is the major source of vitamin D and the main environmental cause of non-melanocytic skin cancers. Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer. The aim of this study was to investigate the association of BsmI and ApaI VDR polymorphisms among patients with non-melanoma cancers and controls. An observational case-control study was conducted in a sample of 154 subjects. We observed no significant effects between these polymorphisms and skin cancer risk. When stratified for gender, GG and AG BsmI polymorphisms significantly increased the risk of basal cell carcinomas in males. In relation to ApaI, all three polymorphisms significantly increased the risk of basal cell carcinoma in males. When stratified for age, we found that being 70 years of age or younger was a protective factor against both skin cancers. Being a female and 70 years old or younger was a protective factor for basal cell carcinoma. A comparison of the frequencies of the VDR genotypes in patients older than 70 years vs. 70 years or younger also revealed age-dependent variations in patients with non-melanoma skin cancer. Our study suggests a role for VDR polymorphisms in non-melanoma skin cancer development.


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