Faculty Opinions recommendation of Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: analysis of recurrent cardiovascular events and mortality.

Introduction: Assessment of left ventricular (LV) dyssynchrony by echocardiography has only a limited ability to predict response to cardiac resynchronizing therapy (CRT) because of high variability of the measurement.Tissue mitral annular displacement (TMAD) is a rapid and robust method for the assessment of left ventricular (LV) longitudinal deformity. We previously reported that TMAD predicts good responders to CRT among patients with severe heart failure (AHA scientific meeting 2012). In the present study, we investigated whether TMAD could predict the long-term prognosis after CRT implantation. Methods: We performed echocardiography study in 41 patients with dilated cardiomyopathy (DCM) before and at 6 month of CRT, using iE33 (Philips Medical Systems). TMAD was measured on an apical 4-chamber image using QLAB software (Philips Medical Systems) to assess the movement of septal- and lateral part of mitral annulus toward apex. We measured the interval between QRS complex to peak of displacement on both regions, and calculated the differences in time-to-peak (dTTP). We defined good response to CRT as decrease in LV end-systolic volume (LVESV) > 15% at 6 month of CRT. We followed the patients to observe cardiovascular events including death, myocardial infarction, stroke and hospital admission for heart failure. Results: The 27 good responders (65.8%) had significantly longer dTTP than the non-responders (156±64 vs. 63±61 msec, p<0.0001). Using 104 msec as a cutoff value, TMAD detected CRT responders with sensitivity of 79% and specificity of 78% (AUC=0.83). We observed 20 cardiac events during follow-up period of 1182±635 days. We found that dTTP was significantly associated with cardiovascular events (p=0.048 by Cox proportional hazard model), and that patients with dTTP≥104ms had better prognosis than others (Figure). Conclusion: TMAD is a promising method for predicting long-term prognosis in patients with DCM receiving CRT.

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P3264 Milrinone versus dobutamine as continuous outpatient parenteral inotropic therapy in pre-transplant chronic heart failure patients with reversible pulmonary hypertension: long-term effects

European Heart Journal ◽

10.1016/s0195-668x(03)95890-8 ◽

2003 ◽

Vol 24 (5) ◽

pp. 617

Author(s):

G KARAVOLIAS

Keyword(s):

Heart Failure ◽

Pulmonary Hypertension ◽

Chronic Heart Failure ◽

Long Term Effects ◽

Inotropic Therapy ◽

Heart Failure Patients

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Hypocalcemic cardiomyopathy after parathyroidectomy in a patient with uremia: A case report and literature review

Journal of International Medical Research ◽

10.1177/0300060520942115 ◽

2020 ◽

Vol 48 (7) ◽

pp. 030006052094211

Author(s):

Wei Zhang ◽

Feng Xue ◽

Quandong Bu ◽

Xuemei Liu

Keyword(s):

Heart Failure ◽

Case Report ◽

Secondary Hyperparathyroidism ◽

Calcium Supplementation ◽

Severe Heart Failure ◽

Cardiac Complications ◽

Refractory Heart Failure ◽

First Case ◽

Insight Into

Hypocalcemia is a rare, but reversible, cause of dilated cardiomyopathy. Although cardiomyopathy may cause severe heart failure, calcium supplementation can reverse heart failure. We report here a patient with uremia and secondary hyperparathyroidism, who was complicated by persistent hypocalcemia and refractory heart failure. The cardiac failure was refractory to treatment with digitalis and diuretics, but dramatically responded to calcium therapy and restoration of normocalcemia. As a result, the patient was eventually diagnosed with hypocalcemic cardiomyopathy. To the best of our knowledge, this is the first case of this disease to be reported in a patient with uremia. Findings from our case may help clinicians to better understand hypocalcemic cardiomyopathy. Our case might also provide new insight into long-term cardiac complications and prognoses of patients undergoing parathyroidectomy due to secondary hyperparathyroidism.

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Acute and long-term effects of enalapril on the cardiovascular response to exercise and exercise tolerance in patients with congestive heart failure

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(85)80269-2 ◽

1985 ◽

Vol 6 (1) ◽

pp. 163-170 ◽

Cited By ~ 90

Author(s):

Mark A. Creager ◽

Barry M. Massie ◽

David P. Faxon ◽

Scott D. Friedman ◽

Barry L. Kramer ◽

...

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Exercise Tolerance ◽

Cardiovascular Response ◽

Long Term Effects ◽

Response To Exercise

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Creatinine Levels at Admission as Predictors of In-Hospital Major Adverse Cardiovascular Events in Acute Heart Failure Patient

ACI (Acta Cardiologia Indonesiana) ◽

10.22146/jaci.v6i1.124 ◽

2020 ◽

Vol 6 (1) ◽

pp. 16-22

Author(s):

Farida Hanum Margolang ◽

Refli Hasan ◽

Abdul Halim Raynaldo ◽

Harris Hasan ◽

Ali Nafiah ◽

...

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

Roc Curve ◽

Cardiovascular Events ◽

Major Adverse Cardiovascular Events ◽

High Morbidity ◽

Roc Curve Analysis ◽

Heart Failure Patients ◽

Long Term Prognosis

Background: Acute heart failure is a global health problem with high morbidity and mortality. Short term and long term prognosis of these patients is poor. Therefore, early identification of patients at high risk for major adverse cardiovascular events (MACEs) during hospitalization was needed to improve outcome. Creatinine levels at admission could be used as predictors of major adverse cardiovascular events in acute heart failure patients because creatinine is a simple and routine biomarker of renal function examined in patients with acute heart failure. This study aimed to determine whether creatinine can be used as a predictor of major adverse adverse cardiovascular events in patients with acute heart failure.Methods: This study is a prospective cohort study of 108 acute heart failure patients treated at H. Adam Malik Hospital from July 2018 to January 2019. Creatinine cut-off points were determined using the ROC curve, then bivariate and multivariate analyzes were performed to determine predictors of major adverse cardiovascular events during hospitalization.Results: From 108 study subjects, 24 (22.2%) subjects experienced major adverse cardiovascular events during hospitalization. The subjects who died were 20 people (83.4%), subjects with arrhythmia were 2 people (8.3%), and those who had stroke were 2 people (8.3 %). Through the ROC curve analysis, we found creatinine cut-off values of ≥1.7 mg / dl (AUC 0.899, 95% CI 0.840- 0.957, p <0.05). Creatinine ≥1.7 mg/dl could predict major adverse cardiovascular events with a sensitivity of 87.5% and specificity of 79.5%. Multivariate analysis showed that creatinine ≥1.7 mg / dl was an independent factor to predict MACEs during hospitalization in this study (OR 18,310, p 0.001) as well as creatinine clearance and heart rate.Conclusion: Creatinine levels at admission is an independent predictor for major adverse cardiovascular events during hospitalization in acute heart failure patients.

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