Abstract
BackgroundHigh-protein (HP) diets have been recommended for weight loss including obese persons. However, the potential effects of HP regimens on kidney health for persons without chronic kidney disease (CKD) are still controversial. MethodsTo investigate the effects of HP diets versus standard protein/low protein (SP/LP) ones on renal function in individuals without CKD, we conducted this meta-analysis. ResultsThirty-nine RCTs including 3400 participants were considered in this meta-analysis. HP diets resulted in an increased GFR (standardized mean difference [SMD] = 0.64, 95% confidence interval [CI]: 0.03, 1.26) and concentrations of serum urea (MD = 1.05, 95% CI: 0.66, 1.44), creatinine (MD = 2.94, 95% CI: 1.30, 4.58), and uric acid (MD = 19.89, 95% CI: 12.35, 27.43) in obese subjects when compared with SP/LP diets. The results in T2D and health participants did not show a notable detrimental effect on renal outcomes. Subgroup analysis showed that an increase in GFR was presented in obese subjects following an intervention shorter than 6 months. No significant differences were found in the urinary albumin excretion between the HP and SP/LP diets in obese and T2D populations, except for the healthy participants which was reported by only one study.ConclusionsThis meta-analysis showed that HP diets were associated with increased GFR, serum urea, creatinine, and uric acid in obese adults. Future studies are warranted to examine whether resulted glomerular hyperfiltration from HP diet can cause kidney damage in obese individuals.