Faculty Opinions recommendation of Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer.

Reprogramming of cellular metabolism is an important, emerging, and universal hallmark of cancer which has received considerable attention during the recent era of cancer research. Cancer cells show characteristic alterations in glucose metabolism in order to fulfill the needs of biosynthesis for tumor proliferation and growth. However, under certain circumstances such as invasion and metastasis, cancer cells are prone to metabolic stress and will require different strategies to meet the high energetic demand from cancer progression. From various metabolic rewiring mechanisms, cancer cells adopt other metabolic pathways with alternative nutrient sources. Therefore, targeting cancer metabolism holds promising but great challenge caused by the metabolic plasticity of cancer cells. This review will discuss characteristic cancer metabolism in detail with special focus on lipid metabolism which is gathering increasingly keen interest, in order to find novel therapeutic approaches to head and neck cancer. By understanding and exploiting the synthesis, oxidation, and storage of fatty acids, we could investigate potential strategies to block cancer proliferation and progression.

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Application of liquid biopsy as multi-functional biomarkers in head and neck cancer

British Journal of Cancer ◽

10.1038/s41416-021-01626-0 ◽

2021 ◽

Author(s):

Vasudha Mishra ◽

Alka Singh ◽

Xiangying Chen ◽

Ari J. Rosenberg ◽

Alexander T. Pearson ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Liquid Biopsy ◽

Functional Biomarkers

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Abstract 1139: Tumor-associated fibroblasts facilitate head and neck cancer metabolism

10.1158/1538-7445.am2015-1139 ◽

2015 ◽

Author(s):

Dhruv Kumar ◽

Partha Kasturi ◽

Bennett Van Houten ◽

Sufi Thomas

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Cancer Metabolism

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The diagnostic performance of perfusion CT in the detection of local tumor recurrence in head and neck cancer

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-209209 ◽

2020 ◽

Vol 76 (2) ◽

pp. 171-177

Author(s):

Daniel Troeltzsch ◽

Stefan Markus Niehues ◽

Tabea Fluegge ◽

Norbert Neckel ◽

Max Heiland ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Tumor Recurrence ◽

Perfusion Ct ◽

Post Treatment ◽

Local Tumor ◽

Local Tumor Recurrence ◽

Maximum Slope ◽

Imaging Tool

BACKGROUND: Detecting local tumor recurrence from post-treatment changes in head and neck cancer (HNC) remains a challenge. Based on the hypothesis that post-therapeutically altered tissue is bradytroph, lower perfusion values are expected in perfusion CT (PCT) while higher perfusion values are expected in recurrent malignant tissue. OBJECTIVES: This prospective study investigates PCT for post-treatment recurrent HNC detection with a maximum slope algorithm. METHODS: A total of 80 patients who received PCT of the head and neck for post-therapy follow-up, of which 63 had no tumor recurrence and 17 presented a histopathologically confirmed recurrence were examined. Regions of interest were placed in the location of the initial tumor, in reference ipsilateral nuchal muscle tissue and the corresponding internal carotid artery. Perfusion was calculated using a single-input maximum slope algorithm. RESULTS: With PCT, recurrent HNC can be differentiated from post-treatment tissue (p < 0.05). It further allows delineating recurrent tumor tissue from benign nuchal tissue of reference (p < 0.05). PCT data of patients with and without recurrent HNC are comparable as perfusion values of reference tissues in patients with and without HNC do not differ (p > 0.05). CONCLUSIONS: PCT in combination with a commercially available maximum slope algorithm offers radiologists a reliable imaging tool to detect recurrent head and neck cancer within post-therapeutically altered tissue.

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