The diagnostic performance of perfusion CT in the detection of local tumor recurrence in head and neck cancer

BACKGROUND: Detecting local tumor recurrence from post-treatment changes in head and neck cancer (HNC) remains a challenge. Based on the hypothesis that post-therapeutically altered tissue is bradytroph, lower perfusion values are expected in perfusion CT (PCT) while higher perfusion values are expected in recurrent malignant tissue. OBJECTIVES: This prospective study investigates PCT for post-treatment recurrent HNC detection with a maximum slope algorithm. METHODS: A total of 80 patients who received PCT of the head and neck for post-therapy follow-up, of which 63 had no tumor recurrence and 17 presented a histopathologically confirmed recurrence were examined. Regions of interest were placed in the location of the initial tumor, in reference ipsilateral nuchal muscle tissue and the corresponding internal carotid artery. Perfusion was calculated using a single-input maximum slope algorithm. RESULTS: With PCT, recurrent HNC can be differentiated from post-treatment tissue (p < 0.05). It further allows delineating recurrent tumor tissue from benign nuchal tissue of reference (p < 0.05). PCT data of patients with and without recurrent HNC are comparable as perfusion values of reference tissues in patients with and without HNC do not differ (p > 0.05). CONCLUSIONS: PCT in combination with a commercially available maximum slope algorithm offers radiologists a reliable imaging tool to detect recurrent head and neck cancer within post-therapeutically altered tissue.

Download Full-text

Value of Dynamic Contrast-Enhanced MRI to Detect Local Tumor Recurrence in Primary Head and Neck Cancer Patients

Medicine ◽

10.1097/md.0000000000003698 ◽

2016 ◽

Vol 95 (19) ◽

pp. e3698 ◽

Cited By ~ 7

Author(s):

Young Jun Choi ◽

Jeong Hyun Lee ◽

Yu Sub Sung ◽

Ra Gyoung Yoon ◽

Ji Eun Park ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Tumor Recurrence ◽

Local Tumor ◽

Local Tumor Recurrence ◽

Dynamic Contrast Enhanced ◽

Contrast Enhanced ◽

Contrast Enhanced Mri

Download Full-text

Effect of Epoetin Alfa on Survival and Cancer Treatment–Related Anemia and Fatigue in Patients Receiving Radical Radiotherapy With Curative Intent for Head and Neck Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2009.22.3693 ◽

2009 ◽

Vol 27 (34) ◽

pp. 5751-5756 ◽

Cited By ~ 39

Author(s):

Peter J. Hoskin ◽

Martin Robinson ◽

Nicholas Slevin ◽

David Morgan ◽

Kevin Harrington ◽

...

Keyword(s):

Head And Neck Cancer ◽

Adverse Events ◽

Cancer Treatment ◽

Head And Neck ◽

Neck Cancer ◽

Functional Assessment ◽

Radical Radiotherapy ◽

Epoetin Alfa ◽

Local Tumor ◽

Curative Intent

Purpose To evaluate the effect of epoetin alfa on local disease-free survival (DFS), overall survival (OS), and cancer treatment–related anemia and fatigue in patients with head and neck cancer receiving radical radiotherapy with curative intent. Patients and Methods Patients (N = 301) with hemoglobin (Hb) less than 15 g/dL were randomly assigned in a ratio of 1:1 to receive radiotherapy plus epoetin alfa (10,000 U subcutaneously [SC] three times weekly if baseline Hb was < 12.5 g/dL; 4,000 U SC three times weekly if baseline Hb ≥ 12.5 g/dL) or radiotherapy alone. Hb levels were monitored weekly. The primary end point was local DFS, defined as the time from random assignment to local disease recurrence or death. Secondary efficacy end points included OS, local tumor response, and local tumor control. Patients were followed at 1, 4, 8, and 12 weeks postradiotherapy and annually for 5 years. Cancer treatment–related anemia and fatigue were evaluated with the Functional Assessment of Cancer Therapy-Anemia and Functional Assessment of Cancer Therapy-Head and Neck. Adverse events were recorded up to 12 weeks postradiotherapy. Results Hb levels increased from baseline with epoetin alfa. The median duration of local DFS was not statistically different between groups (observation, 35.42 months; epoetin alfa, 31.47 months; hazard ratio, 1.04; 95% CI, 0.77 to 1.41). Groups did not significantly differ in DFS, OS, tumor outcomes, or cancer treatment–related anemia or fatigue. No new or unexpected adverse events were observed. Conclusion Addition of epoetin alfa to radical radiotherapy did not affect survival, tumor outcomes, anemia, or fatigue positively or negatively in patients with head and neck cancer.

Download Full-text

Perfusion CT of head and neck cancer

European Journal of Radiology ◽

10.1016/j.ejrad.2013.12.008 ◽

2014 ◽

Vol 83 (3) ◽

pp. 537-544 ◽

Cited By ~ 56

Author(s):

Ahmed Abdel Khalek Abdel Razek ◽

Ahmed Mohamed Tawfik ◽

Lamiaa Galal Ali Elsorogy ◽

Nermin Yehia Soliman

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Perfusion Ct

Download Full-text

Complete Response After Definitive Radiotherapy for Node-Positive Head and Neck Cancer: The Use of Post-treatment Physical Exam Versus Computed Tomography in the Management of the Neck

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2005.07.323 ◽

2005 ◽

Vol 63 ◽

pp. S186

Author(s):

S.L. Liauw ◽

R.J. Amdur ◽

C.G. Morris ◽

A. Mancuso ◽

W.M. Mendenhall

Keyword(s):

Computed Tomography ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Complete Response ◽

Post Treatment ◽

Physical Exam ◽

Definitive Radiotherapy ◽

Node Positive

Download Full-text

Role of perfusion CT in the evaluation of functional primary tumour response after radiochemotherapy in head and neck cancer: preliminary findings

British Journal of Radiology ◽

10.1259/bjr.20151070 ◽

2016 ◽

Vol 89 (1065) ◽

pp. 20151070 ◽

Cited By ~ 5

Author(s):

Stefano Ursino ◽

Lorenzo Faggioni ◽

Federica Guidoccio ◽

Patrizia Ferrazza ◽

Veronica Seccia ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Primary Tumour ◽

Tumour Response ◽

Perfusion Ct

Download Full-text

Analysis of the frequency and degree of temporomandibular disorder in patients with head and neck cancer undergoing radiotherapy

Fisioterapia em Movimento ◽

10.1590/0103-5150.029.002.ao15 ◽

2016 ◽

Vol 29 (2) ◽

pp. 361-368 ◽

Cited By ~ 1

Author(s):

Douglas Roberto Pegoraro ◽

Barbara Zanchet ◽

Caroline de Oliveira Guariente ◽

Josemara de Paula Rocha ◽

Juliana Secchi Batista

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Temporomandibular Disorder ◽

Malignant Neoplasm ◽

Post Treatment ◽

Chi Square ◽

Significance Level ◽

Chi Square Test ◽

Quantitative Descriptive

Abstract Introduction: Head and neck cancer is responsible for an increasing incidence of primary malignant neoplasm cases worldwide. Radiotherapy is one of the treatments of choice for this type of cancer, but it can cause adverse effects, such as temporomandibular disorder. The objective of this study was to characterize the degree and frequency of temporomandibular disorder in patients with head and neck cancer undergoing radiotherapy. Method: This research was quantitative, descriptive and exploratory. The sample consisted of 22 patients that answered assessment questions and the Helkimo anamnestic questionnaire, modified by Fonseca (1992). The data were collected from May to October 2014, and statistically analyzed using the Chi-square test, with a significance level of p ≤ 0.05. Results: Of the 22 patients, 86.4 % were male, with a mean age of 58.86 ± 9.41 years. Temporomandibular disorder was present in 31.8% of the subjects, based on the assessment prior to radiotherapy, and in 59.1% in the post-treatment assessment. Among all questions, the most frequent was "Do you use only one side of the mouth to chew?" with 22.7% "yes" answers, both at the first assessment and at the post treatment. Conclusion: According to the results of this study, temporomandibular disorder is a disease that is present with a high prevalence in people diagnosed with head and neck cancer undergoing radiotherapy.

Download Full-text

Post‐Treatment Head and Neck Cancer Care: National Audit and Analysis of Current Practice in the United Kingdom

Clinical Otolaryngology ◽

10.1111/coa.13616 ◽

2020 ◽

Vol 46 (1) ◽

pp. 284-294

Author(s):

◽

Matthew Ellis ◽

George Garas ◽

John Hardman ◽

Maha Khan ◽

...

Keyword(s):

Head And Neck Cancer ◽

United Kingdom ◽

Head And Neck ◽

Neck Cancer ◽

Cancer Care ◽

Current Practice ◽

Post Treatment ◽

National Audit ◽

The United Kingdom

Download Full-text

Head and neck cancer survivors’ preferences for and evaluations of a post-treatment dietary intervention

Nutrition Journal ◽

10.1186/s12937-019-0479-6 ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 1

Author(s):

Sylvia L. Crowder ◽

Katherine G. Douglas ◽

Andrew D. Frugé ◽

William R. Carroll ◽

Sharon A. Spencer ◽

...

Keyword(s):

Program Evaluation ◽

Head And Neck Cancer ◽

Cancer Survivors ◽

Head And Neck ◽

Neck Cancer ◽

Dietary Intervention ◽

Post Treatment ◽

Leafy Vegetables ◽

Registered Dietitian ◽

Study Program

Abstract Background Dietary preferences vary depending on cancer type. The purpose of this study was to report dietary intervention preferences and a study program evaluation from post-treatment head and neck cancer survivors participating in a dietary intervention. Methods Between January 2015 and August 2016, 24 head and neck cancer survivors participated in a 12-week randomized clinical dietary intervention trial that promoted weekly consumption of 2.5 cups of cruciferous vegetables and 3.5 cups of green leafy vegetables. At study completion, survivors completed a preferences survey and a study program evaluation to probe interests and improvement aspects for planning future dietary intervention trials. Descriptive statistics (means and frequencies) were generated for multiple choice question responses. Responses to open-ended questions were recorded and grouped based on themes, and verified by quality assurance checks by a second study team member. Results Twenty-three survivors completed the preferences and evaluation surveys (response rate 96%). Overall, most participants reported a preference for one-on-one telephone counseling from a registered dietitian nutritionist before beginning treatment. Ninety-six percent of participants ranked the overall study program as “very good” to “excellent,” and all agreed the objectives of the study were clear, the study staff was helpful and easy to contact, and the registered dietitian nutritionist was knowledgeable. Conclusions Future research and dietary intervention planning for head and neck cancer survivors should focus on strategies to promote one-on-one telephone or other distance-based counseling combined with face-to-face visits, according to survivor preference.

Download Full-text