Faculty Opinions recommendation of Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.

2015 ◽  
Author(s):  
Ernest Arenas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Liver X Receptors ◽  
X Receptors

scholarly journals Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

2007 ◽  
Vol 104 (25) ◽  
pp. 10601-10606 ◽  
Author(s):  
N. Zelcer ◽  
N. Khanlou ◽  
R. Clare ◽  
Q. Jiang ◽  
E. G. Reed-Geaghan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Liver X Receptors ◽  
X Receptors

scholarly journals Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Jasminka Štefulj ◽  
Ute Panzenboeck ◽  
Patrick Hof ◽  
Goran Šimić
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transcription Factors ◽  
Amyloid Beta ◽  
Cholesterol Metabolism ◽  
Cholesterol Homeostasis ◽  
Tau Proteins ◽  
Liver X Receptors ◽  
Proteins Metabolism ◽  
X Receptors

AbstractThe pathogenesis of Alzheimer’s disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.

scholarly journals Lipid Metabolism and Neuroinflammation in Alzheimer's Disease: A Role for Liver X Receptors

2012 ◽  
Vol 33 (5) ◽  
pp. 715-746 ◽  
Author(s):  
Jihong Kang ◽  
Serge Rivest
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lipid Metabolism ◽  
Neurodegenerative Disease ◽  
Cholesterol Metabolism ◽  
Significant Risk ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Liver X Receptors ◽  
X Receptors

Liver X receptors (LXR) are nuclear receptors that have emerged as key regulators of lipid metabolism. In addition to their functions as cholesterol sensors, LXR have also been found to regulate inflammatory responses in macrophages. Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive cognitive decline associated with inflammation. Evidence indicates that the initiation and progression of AD is linked to aberrant cholesterol metabolism and inflammation. Activation of LXR can regulate neuroinflammation and decrease amyloid-β peptide accumulation. Here, we highlight the role of LXR in orchestrating lipid homeostasis and neuroinflammation in the brain. In addition, diabetes mellitus is also briefly discussed as a significant risk factor for AD because of the appearing beneficial effects of LXR on glucose homeostasis. The ability of LXR to attenuate AD pathology makes them potential therapeutic targets for this neurodegenerative disease.

scholarly journals Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease

2019 ◽  
Vol 176 (18) ◽  
pp. 3599-3610 ◽  
Author(s):  
Nicholas F. Fitz ◽  
Kyong Nyon Nam ◽  
Radosveta Koldamova ◽  
Iliya Lefterov
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nuclear Receptors ◽  
Therapeutic Targeting ◽  
Retinoid X Receptors ◽  
X Receptors

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

Formation of paired helical filaments in Alzheimer's disease

1984 ◽  
Vol 42 ◽  
pp. 302-303
Author(s):  
J. Metuzals ◽  
D. F. Clapin ◽  
V. Montpetit
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontal Lobe ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Normal Brain ◽  
Protein Assemblies ◽  
Electron Microscopic ◽  
Helical Symmetry ◽  
Structural Levels

Information on the conformation of paired helical filaments (PHF) and the neurofilamentous (NF) network is essential for an understanding of the mechanisms involved in the formation of the primary lesions of Alzheimer's disease (AD): tangles and plaques. The structural and chemical relationships between the NF and the PHF have to be clarified in order to discover the etiological factors of this disease. We are investigating by stereo electron microscopic and biochemical techniques frontal lobe biopsies from patients with AD and squid giant axon preparations. The helical nature of the lesion in AD is related to pathological alterations of basic properties of the nervous system due to the helical symmetry that exists at all hierarchic structural levels in the normal brain. Because of this helical symmetry of NF protein assemblies and PHF, the employment of structure reconstruction techniques to determine the conformation, particularly the handedness of these structures, is most promising. Figs. 1-3 are frontal lobe biopsies.

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