Faculty Opinions recommendation of A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.

2017 ◽  
Author(s):  
Nicola Heller
Keyword(s):  
Protective Role ◽  
Pulmonary Injury ◽  
Injury And Repair

scholarly journals A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair

2015 ◽  
Vol 9 (1) ◽  
pp. 240-253 ◽  
Author(s):  
D Karo-Atar ◽  
A Bordowitz ◽  
O Wand ◽  
M Pasmanik-Chor ◽  
I E Fernandez ◽  
...  
Keyword(s):  
Protective Role ◽  
Pulmonary Injury ◽  
Injury And Repair

Endotoxin protection against oxygen-induced acute and chronic lung injury

1979 ◽  
Vol 47 (3) ◽  
pp. 577-581 ◽  
Author(s):  
L. Frank ◽  
R. J. Roberts
Keyword(s):  
Protective Role ◽  
Histological Evaluation ◽  
Treated Animal ◽  
Pulmonary Injury ◽  
Significant Protection ◽  
Adult Rats ◽  
Enzyme Systems ◽  
Reticular Fiber ◽  
Fiber Deposition ◽  
Increased Activity

Small dosages of endotoxin (100--500 micrograms/kg) provide significant protection against the acute manifestations of pulmonary O2 toxicity and lethality. Ninety-seven percent of endotoxin-treated adult rats survived a 72-h exposure to greater than or equal to 95% O2 with mimimal lung changes, compared to 32% of control animals (P less than 0.01). Exposure to greater than or equal to 95% O2 for 7 days resulted in a 20% survival rate in untreated control rats vs. 98% survival in endotoxin-treated rats (P LESS THan 0.01). Histological evaluation of lung from survivors revealed substantially less collagen and reticular fiber deposition in the endotoxin-treated animal lungs. Endotoxin treatment was associated with increased activity of the protectant antioxidant enzyme systems of the lung in an apparent dose-response manner. Endotoxin's protective activity against O2 toxicity does not appear to depend on an initial toxic insult to the lung like with alpha-naphthylthiourea, oleic acid, or alloxan treatment. The data support a protective role for endotoxin against the acute and the more chronic manifestations of O2-induced pulmonary injury.

scholarly journals A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury

2005 ◽  
Vol 115 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Chun-Xiao Sun ◽  
Hays W. Young ◽  
Jose G. Molina ◽  
Jonathan B. Volmer ◽  
Jurgen Schnermann ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Protective Role ◽  
Pulmonary Injury ◽  
A1 Adenosine Receptor

scholarly journals The Rise and Fall of Hyaluronan in Respiratory Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Mark E. Lauer ◽  
Raed A. Dweik ◽  
Stavros Garantziotis ◽  
Mark A. Aronica
Keyword(s):  
Respiratory Diseases ◽  
Tissue Injury ◽  
Pulmonary Vasculature ◽  
Early Event ◽  
Pulmonary Injury ◽  
Heavy Chains ◽  
Injury And Repair ◽  
Proper Resolution ◽  
Airway Physiology

In normal airways, hyaluronan (HA) matrices are primarily located within the airway submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following pulmonary injury, elevated levels of HA matrices accumulate in these regions, and in respiratory secretions, correlating with the extent of injury. Animal models have provided important insight into the role of HA in the onset of pulmonary injury and repair, generally indicating that the induction of HA synthesis is an early event typically preceding fibrosis. The HA that accumulates in inflamed airways is of a high molecular weight (>1600 kDa) but can be broken down into smaller fragments (<150 kDa) by inflammatory and disease-related mechanisms that have profound effects on HA pathobiology. During inflammation in the airways, HA is often covalently modified with heavy chains from inter-alpha-inhibitor via the enzyme tumor-necrosis-factor-stimulated-gene-6 (TSG-6) and this modification promotes the interaction of leukocytes with HA matrices at sites of inflammation. The clearance of HA and its return to normal levels is essential for the proper resolution of inflammation. These data portray HA matrices as an important component of normal airway physiology and illustrate its integral roles during tissue injury and repair among a variety of respiratory diseases.

scholarly journals Role of NOS2 in pulmonary injury and repair in response to bleomycin

2016 ◽  
Vol 91 ◽  
pp. 293-301 ◽  
Author(s):  
Changjiang Guo ◽  
Elena Atochina-Vasserman ◽  
Helen Abramova ◽  
Blessy George ◽  
Veleeparambil Manoj ◽  
...  
Keyword(s):  
Pulmonary Injury ◽  
Injury And Repair

scholarly journals Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice

2016 ◽  
Vol 5 (1) ◽  
pp. 268-277 ◽  
Author(s):  
Yuqing Zhu ◽  
Jinquan Li ◽  
Zhuo Wu ◽  
Yu Lu ◽  
Huihui You ◽  
...  
Keyword(s):  
Vitamin E ◽  
Human Activity ◽  
Protective Role ◽  
Lower Atmosphere ◽  
Acute Exposure ◽  
Pulmonary Injury ◽  
Nrf2 Pathway

Ozone (O3) in the lower atmosphere is generally derived from various sources of human activity.

A Comprehensive Ultrastructural Study of Pulmonary Injury and Repair in the Rat Resulting From Exposures to Less Than One PPM Ozone

CHEST Journal ◽  
1974 ◽  
Vol 65 (4) ◽  
pp. 11S-12S ◽  
Author(s):  
R.J. Stephens ◽  
M.J. Evans ◽  
M.F. Sloan ◽  
G. Freeman
Keyword(s):  
Ultrastructural Study ◽  
Pulmonary Injury ◽  
Injury And Repair

Protective role of peroxiredoxin-4 in heart failure

2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq
Keyword(s):  
Heart Failure ◽  
Cardiac Fibroblasts ◽  
Protective Role ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Galectin 3 ◽  
Consequent Increase ◽  
And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

Parenting Behaviors and Anxiety in Young Adults

2015 ◽  
Vol 36 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Erin N. Stevens ◽  
Joseph R. Bardeen ◽  
Kyle W. Murdock
Keyword(s):  
Effortful Control ◽  
Parenting Behaviors ◽  
Protective Role ◽  
Anxiety Symptoms ◽  
Interactive Effects ◽  
Parental Overprotection ◽  
High Control ◽  
Development Of Anxiety ◽  
The Relationship

Parenting behaviors – specifically behaviors characterized by high control, intrusiveness, rejection, and overprotection – and effortful control have each been implicated in the development of anxiety pathology. However, little research has examined the protective role of effortful control in the relation between parenting and anxiety symptoms, specifically among adults. Thus, we sought to explore the unique and interactive effects of parenting and effortful control on anxiety among adults (N = 162). Results suggest that effortful control uniquely contributes to anxiety symptoms above and beyond that of any parenting behavior. Furthermore, effortful control acted as a moderator of the relationship between parental overprotection and anxiety, such that overprotection is associated with anxiety only in individuals with lower levels of effortful control. Implications for potential prevention and intervention efforts which specifically target effortful control are discussed. These findings underscore the importance of considering individual differences in self-regulatory abilities when examining associations between putative early-life risk factors, such as parenting, and anxiety symptoms.

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