Faculty Opinions recommendation of Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress.

2017 ◽  
Author(s):  
Paul Enck
Keyword(s):  
Medical Students ◽  
Gut Microbiota ◽  
Lactobacillus Casei ◽  
Fermented Milk ◽  
Academic Stress

scholarly journals Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress

2016 ◽  
Vol 82 (12) ◽  
pp. 3649-3658 ◽  
Author(s):  
Akito Kato-Kataoka ◽  
Kensei Nishida ◽  
Mai Takada ◽  
Mitsuhisa Kawai ◽  
Hiroko Kikuchi-Hayakawa ◽  
...  
Keyword(s):  
Placebo Group ◽  
Medical Students ◽  
16S Rrna ◽  
Gut Microbiota ◽  
Lactobacillus Casei ◽  
Fermented Milk ◽  
Rrna Gene ◽  
Daily Consumption ◽  
Content Type ◽  
Abdominal Symptoms

ABSTRACTStress-induced abdominal dysfunction is an attractive target for probiotics. To investigate the effects of the probioticLactobacillus caseistrain Shirota on abdominal dysfunction, a double-blind, placebo-controlled trial was conducted with healthy medical students undertaking an authorized nationwide examination for academic advancement. For 8 weeks, until the day before the examination, 23 and 24 subjects consumed anL. caseistrain Shirota-fermented milk and a placebo milk daily, respectively. In addition to assessments of abdominal symptoms, psychophysical state, and salivary stress markers, gene expression changes in peripheral blood leukocytes and composition of the gut microbiota were analyzed using DNA microarray analysis and 16S rRNA gene amplicon sequence analysis, respectively, before and after the intervention. Stress-induced increases in a visual analog scale measuring feelings of stress, the total score of abdominal dysfunction, and the number of genes with changes in expression of more than 2-fold in leukocytes were significantly suppressed in theL. caseistrain Shirota group compared with those in the placebo group. A significant increase in salivary cortisol levels before the examination was observed only in the placebo group. The administration ofL. caseistrain Shirota, but not placebo, significantly reduced gastrointestinal symptoms. Moreover, 16S rRNA gene amplicon sequencing demonstrated that theL. caseistrain Shirota group had significantly higher numbers of species, a marker of the alpha-diversity index, in their gut microbiota and a significantly lower percentage ofBacteroidaceaethan the placebo group. Our findings indicate that the daily consumption of probiotics, such asL. caseistrain Shirota, preserves the diversity of the gut microbiota and may relieve stress-associated responses of abdominal dysfunction in healthy subjects exposed to stressful situations.IMPORTANCEA novel clinical trial was conducted with healthy medical students under examination stress conditions. It was demonstrated that the daily consumption of lactic acid bacteria provided health benefits to prevent the onset of stress-associated abdominal symptoms and a good change of gut microbiota in healthy medical students.

Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress

2016 ◽  
Vol 7 (2) ◽  
pp. 153-156 ◽  
Author(s):  
A. Kato-Kataoka ◽  
K. Nishida ◽  
M. Takada ◽  
K. Suda ◽  
M. Kawai ◽  
...  
Keyword(s):  
Placebo Group ◽  
Medical Students ◽  
Stress Responses ◽  
Salivary Cortisol ◽  
Lactobacillus Casei ◽  
Controlled Trial ◽  
Fermented Milk ◽  
Physical Symptoms ◽  
Intervention Period ◽  
Daily Consumption

This pilot study investigated the effects of the probiotic Lactobacillus casei strain Shirota (LcS) on psychological, physiological, and physical stress responses in medical students undertaking an authorised nationwide examination for promotion. In a double-blind, placebo-controlled trial, 24 and 23 healthy medical students consumed a fermented milk containing LcS and a placebo milk, respectively, once a day for 8 weeks until the day before the examination. Psychophysical state, salivary cortisol, faecal serotonin, and plasma L-tryptophan were analysed on 5 different sampling days (8 weeks before, 2 weeks before, 1 day before, immediately after, and 2 weeks after the examination). Physical symptoms were also recorded in a diary by subjects during the intervention period for 8 weeks. In association with a significant elevation of anxiety at 1 day before the examination, salivary cortisol and plasma L-tryptophan levels were significantly increased in only the placebo group (P<0.05). Two weeks after the examination, the LcS group had significantly higher faecal serotonin levels (P<0.05) than the placebo group. Moreover, the rate of subjects experiencing common abdominal and cold symptoms and total number of days experiencing these physical symptoms per subject were significantly lower in the LcS group than in the placebo group during the pre-examination period at 5-6 weeks (each P<0.05) and 7-8 weeks (each P<0.01) during the intervention period. Our results suggest that the daily consumption of fermented milk containing LcS may exert beneficial effects preventing the onset of physical symptoms in healthy subjects exposed to stressful situations.

Association of life habits and fermented milk intake with stool frequency, defecatory symptoms and intestinal microbiota in healthy Japanese adults

2019 ◽  
Vol 10 (8) ◽  
pp. 841-854 ◽  
Author(s):  
T. Shima ◽  
R. Amamoto ◽  
C. Kaga ◽  
Y. Kado ◽  
T. Sasai ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lactobacillus Casei ◽  
Fermented Milk ◽  
Stool Frequency ◽  
Milk Consumption ◽  
Microbiota Composition ◽  
Japanese Adults ◽  
Probiotic Lactobacillus ◽  
Bowel Movements ◽  
Gut Microbiota Composition

Few studies have examined the effects of smoking habit, the frequency of alcohol drinking, exercise, and fermented milk consumption on defecatory symptoms and gut microbiota composition, and particularly their interactive effects. We examined the effect of these lifestyle factors on bowel movements and gut microbiota composition in 366 healthy Japanese adults by analysis of covariance. Smoking did not affect defecatory symptoms but was negatively correlated with total bacteria and Enterococcus counts. Drinking frequency was significantly positively correlated with a feeling of incomplete evacuation and counts of the Bacteroides fragilis group and Acidaminococcus groups. Exercise frequency tended to be negatively correlated with the Bristol Stool Form Scale score and was significantly negatively correlated with the counts of Enterobacteriaceae and positively correlated with the Prevotella counts in the faeces. The frequency of fermented milk consumption was not significant but tended to be positively correlated with stool frequency. The frequency of fermented milk consumption was significantly positively correlated with the counts of the Atopobium cluster, Eubacterium cylindroides group, Acidaminococcus group, Clostridium ramosum subgroup, and Lactobacillus in the faeces. The frequency of consumption of probiotic Lactobacillus casei-containing fermented milk was significantly positively correlated with stool frequency. The counts of probiotic Lactobacillus casei in the stool was positively correlated with the counts of Bifidobacterium and total Lactobacillus. These results suggest that smoking, alcohol drinking, exercise, and consumption of fermented milk, particularly containing probiotic L. casei, differently affect bowel movements and gut microbiota composition in healthy Japanese adults.

Lactobacillus casei LC89 exert antidiabetic effects through regulating hepatic glucagon response and gut microbiota in type 2 diabetic mice

2021 ◽  
Author(s):  
Yongli Zhang ◽  
Tao Wu ◽  
Wen Li ◽  
Yunjiao Zhao ◽  
Hairong Long ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Molecular Mechanism ◽  
Lactobacillus Casei ◽  
Diabetic Mice ◽  
Antihyperglycemic Activity ◽  
Underlying Mechanisms ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Previous study suggests Lactobacillus casei exhibit antihyperglycemic activity, however, the molecular mechanism has rarely been elucidated. Here, the anti-diabetic effects and underlying mechanisms of Lactobacillus casei LC89 were investigated in...

IMMUNOLOGICAL ASPECT OF ORAL ADMINISTRATION OF THE PROBIOTIC LACTOBACILLUS CASEI LB 148 UNDER COLD STRESS IN ANIMALS

2020 ◽  
Author(s):  
G.V. Kozlovskaya ◽  
◽  
M.I. Zinevich ◽  
Y.E. Kozlovsky ◽  
T.I. Khomyakova ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Oral Administration ◽  
Cold Stress ◽  
Gut Microbiome ◽  
Lactobacillus Casei ◽  
Causative Factor ◽  
Sprague Dawley ◽  
Immunological Aspect ◽  
Intestinal Lymph ◽  
Probiotic Lactobacillus

Gut microbiome changes is considered as a basic causative factor of stress-associated diseases. Probiotics are usually used for the correction of disbiosis. The aim of the investigation was the study of the effects of oral probiotic Lactobacillus casei LB 148 use onto the gut microbiota as well as the number and total square of intestinal lymph nodules of rats Sprague Dawley at in health rats and under the cold stress

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