Faculty Opinions recommendation of Dual function of UPF3B in early and late translation termination.

2017 ◽  
Author(s):  
Miles Wilkinson
Keyword(s):  
Translation Termination ◽  
Dual Function

scholarly journals Dual function of UPF3B in early and late translation termination

2017 ◽  
Vol 36 (20) ◽  
pp. 2968-2986 ◽  
Author(s):  
Gabriele Neu‐Yilik ◽  
Etienne Raimondeau ◽  
Boris Eliseev ◽  
Lahari Yeramala ◽  
Beate Amthor ◽  
...  
Keyword(s):  
Translation Termination ◽  
Dual Function

Influence of nascent polypeptide positive charges on translation dynamics

2020 ◽  
Vol 477 (15) ◽  
pp. 2921-2934
Author(s):  
Rodrigo D. Requião ◽  
Géssica C. Barros ◽  
Tatiana Domitrovic ◽  
Fernando L. Palhano
Keyword(s):  
Mrna Decay ◽  
Translation Termination ◽  
Published Data ◽  
Translation Efficiency ◽  
Amino Acid Residues ◽  
High Concentration ◽  
Strong Argument ◽  
Translation Arrest ◽  
Exit Tunnel ◽  
Positively Charged

Protein segments with a high concentration of positively charged amino acid residues are often used in reporter constructs designed to activate ribosomal mRNA/protein decay pathways, such as those involving nonstop mRNA decay (NSD), no-go mRNA decay (NGD) and the ribosome quality control (RQC) complex. It has been proposed that the electrostatic interaction of the positively charged nascent peptide with the negatively charged ribosomal exit tunnel leads to translation arrest. When stalled long enough, the translation process is terminated with the degradation of the transcript and an incomplete protein. Although early experiments made a strong argument for this mechanism, other features associated with positively charged reporters, such as codon bias and mRNA and protein structure, have emerged as potent inducers of ribosome stalling. We carefully reviewed the published data on the protein and mRNA expression of artificial constructs with diverse compositions as assessed in different organisms. We concluded that, although polybasic sequences generally lead to lower translation efficiency, it appears that an aggravating factor, such as a nonoptimal codon composition, is necessary to cause translation termination events.

THE BALANCE OF PROBABILITY: STATISTICS AND THE DIACHRONIC STUDY OF ANCIENT HEBREW

2017 ◽  
Vol 25 (2) ◽  
pp. 927-960
Author(s):  
Jarod Jacobs
Keyword(s):  
Dead Sea Scrolls ◽  
Dead Sea ◽  
Biblical Hebrew ◽  
Large Datasets ◽  
Dual Function ◽  
Statistical Tools ◽  
Masoretic Text ◽  
Linguistic Research ◽  
Recent Debate ◽  
Diachronic Study

In this article, I discuss three statistical tools that have proven pivotal in linguistic research, particularly those studies that seek to evaluate large datasets. These tools are the Gaussian Curve, significance tests, and hierarchical clustering. I present a brief description of these tools and their general uses. Then, I apply them to an analysis of the variations between the “biblical” DSS and our other witnesses, focusing upon variations involving particles. Finally, I engage the recent debate surrounding the diachronic study of Biblical Hebrew. This article serves a dual function. First, it presents statistical tools that are useful for many linguistic studies. Second, it develops an analysis of the he-locale, as it is used in the “biblical” Dead Sea Scrolls, Masoretic Text, and Samaritan Pentateuch. Through that analysis, this article highlights the value of inferential statistical tools as we attempt to better understand the Hebrew of our ancient witnesses.

Dual-Function, Light Switchable Cobalt Catalysis via Active Site Metamorphosis

2019 ◽  
Author(s):  
Enrico Bergamaschi ◽  
Frédéric Beltran ◽  
Christopher Teskey
Keyword(s):  
Visible Light ◽  
Active Site ◽  
Catalytic Site ◽  
Dual Function ◽  
Catalytic Systems ◽  
Hydride Complex ◽  
Dual Functional ◽  
Multiple Processes ◽  
Olefin Migration

<p></p><p></p><p>Switchable catalysis offers opportunities to control the rate or selectivity of a reaction <i>via</i> a stimulus such as pH or light. However, few examples of switchable catalytic systems that can facilitate multiple processes exist. Here we report a rare example of such dual-functional, switchable catalysis. Featuring an easily prepared, bench-stable cobalt(I) hydride complex in conjunction with pinacolborane, we can completely alter the reaction outcome between two widely employed transformations – olefin migration and hydroboration – with visible light as the sole trigger. This dichotomy arises from ligand photodissociation which leads to metamorphosis of the active catalytic site, resulting in divergent mechanistic pathways.</p><p></p><p></p>

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