Faculty Opinions recommendation of Human gut bacteria contain acquired interbacterial defence systems.

2019 ◽  
Author(s):  
Michael Kurilla
Keyword(s):  
Gut Bacteria ◽  
Human Gut

scholarly journals Flavonoid-Modifying Capabilities of the Human Gut Microbiome—An In Silico Study

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2688
Author(s):  
Tobias Goris ◽  
Rafael R. C. Cuadrat ◽  
Annett Braune
Keyword(s):  
Gut Microbiome ◽  
Large Scale ◽  
Health Impact ◽  
Gut Bacteria ◽  
Human Gut ◽  
Positive Health ◽  
Human Gut Microbiome ◽  
Nutritional Recommendations ◽  
Genes Encoding ◽  
A Minor

Flavonoids are a major group of dietary plant polyphenols and have a positive health impact, but their modification and degradation in the human gut is still widely unknown. Due to the rise of metagenome data of the human gut microbiome and the assembly of hundreds of thousands of bacterial metagenome-assembled genomes (MAGs), large-scale screening for potential flavonoid-modifying enzymes of human gut bacteria is now feasible. With sequences of characterized flavonoid-transforming enzymes as queries, the Unified Human Gastrointestinal Protein catalog was analyzed and genes encoding putative flavonoid-modifying enzymes were quantified. The results revealed that flavonoid-modifying enzymes are often encoded in gut bacteria hitherto not considered to modify flavonoids. The enzymes for the physiologically important daidzein-to-equol conversion, well studied in Slackiaisoflavoniconvertens, were encoded only to a minor extent in Slackia MAGs, but were more abundant in Adlercreutzia equolifaciens and an uncharacterized Eggerthellaceae species. In addition, enzymes with a sequence identity of about 35% were encoded in highly abundant MAGs of uncultivated Collinsella species, which suggests a hitherto uncharacterized daidzein-to-equol potential in these bacteria. Of all potential flavonoid modification steps, O-deglycosylation (including derhamnosylation) was by far the most abundant in this analysis. In contrast, enzymes putatively involved in C-deglycosylation were detected less often in human gut bacteria and mainly found in Agathobacter faecis (formerly Roseburia faecis). Homologs to phloretin hydrolase, flavanonol/flavanone-cleaving reductase and flavone reductase were of intermediate abundance (several hundred MAGs) and mainly prevalent in Flavonifractor plautii. This first comprehensive insight into the black box of flavonoid modification in the human gut highlights many hitherto overlooked and uncultured bacterial genera and species as potential key organisms in flavonoid modification. This could lead to a significant contribution to future biochemical-microbiological investigations on gut bacterial flavonoid transformation. In addition, our results are important for individual nutritional recommendations and for biotechnological applications that rely on novel enzymes catalyzing potentially useful flavonoid modification reactions.

Coculture of primary human colon monolayer with human gut bacteria

2021 ◽  
Author(s):  
Jianbo Zhang ◽  
Victor Hernandez-Gordillo ◽  
Martin Trapecar ◽  
Charles Wright ◽  
Mao Taketani ◽  
...  
Keyword(s):  
Human Colon ◽  
Gut Bacteria ◽  
Human Gut

scholarly journals Selective fermentation of gentiobiose-derived oligosaccharides by human gut bacteria and influence of molecular weight

2006 ◽  
Vol 56 (3) ◽  
pp. 383-388 ◽  
Author(s):  
María Luz Sanz ◽  
Gregory L. Côté ◽  
Glenn R. Gibson ◽  
Robert A. Rastall
Keyword(s):  
Molecular Weight ◽  
Gut Bacteria ◽  
Human Gut

scholarly journals Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans

Cell ◽  
2019 ◽  
Vol 179 (1) ◽  
pp. 59-73.e13 ◽  
Author(s):  
Michael L. Patnode ◽  
Zachary W. Beller ◽  
Nathan D. Han ◽  
Jiye Cheng ◽  
Samantha L. Peters ◽  
...  
Keyword(s):  
Gut Bacteria ◽  
Human Gut ◽  
Interspecies Competition

scholarly journals Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase

2014 ◽  
Vol 15 (1) ◽  
pp. 112 ◽  
Author(s):  
Anna Sheydina ◽  
Ruth Y Eberhardt ◽  
Daniel J Rigden ◽  
Yuanyuan Chang ◽  
Zhanwen Li ◽  
...  
Keyword(s):  
Structural Genomics ◽  
Glycoside Hydrolase ◽  
Gut Bacteria ◽  
Protein Families ◽  
Human Gut ◽  
Uncharacterized Protein

scholarly journals Bacteria Effect On Health and Human-Review

2019 ◽  
Vol 1 (1) ◽  
pp. 23-27
Author(s):  
Saali Mohammed Lutfi
Keyword(s):  
Inflammatory Bowel Disease ◽  
Human Health ◽  
Chronic Diseases ◽  
Bowel Disease ◽  
Dietary Habits ◽  
Gut Bacteria ◽  
Nerve Function ◽  
Human Gut ◽  
Inflammatory Bowel ◽  
Bacteria Communities

Microbes are an important component of the microbiology  eco-system in the human gut, which is colonized by 1014 bacteria , ten times more than the human cells. Gut bacteria take  an important role in human health, like  supplying essential nutrients, synthesizing vit. K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function. However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.

Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies

2018 ◽  
Vol 3 (4) ◽  
pp. 514-522 ◽  
Author(s):  
Melanie Tramontano ◽  
Sergej Andrejev ◽  
Mihaela Pruteanu ◽  
Martina Klünemann ◽  
Michael Kuhn ◽  
...  
Keyword(s):  
Gut Bacteria ◽  
Human Gut
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