IL-10 AND IL-35 AS INFLAMMATION REGULATORS IN PATIENTS WITH ALLERGIC RHINITIS AND MILD ATOPIC ASTHMA

Background. Significantly less is known about the immunoregulative cytokines, especially in allergic airway disease. This study aims to present the involvement of IL-35 and IL-10 in patients with allergic rhinitis (AR) and allergic bronchial asthma (BA). Methodology. The study comprised 71 patients –AR, patients with concomitant AR and mild atopic BA, and healthy controls (HC). We examined the serum levels of IL-35 and IL-10, along with other instrumental examinations, between March and September 2021. Findings. Levels of the regulatory cytokines IL-35 and IL-10 were significantly lower in patients than in HC (87.19±11.90 vs. 96.12±1.79 pg/ml; and 30.26±17.55 vs. 111.56±65.03 pg/ml, respectively). Furthermore, threefold higher serum IL-10 levels were found in healthy subjects compared to patients (p = 0.006). No difference in the levels of interleukins was found between the studied groups. Conclusions. Our results indicate that elevated IL-35 and IL-10 may play an essential role in reducing the activity of underlying allergic inflammation in allergic respiratory diseases, although no difference in the levels of the studied cytokines was found between the different groups of patients. Therefore, we can speculate that the immunosuppressive cytokines IL-35 and IL-10 were involved in maintaining the healthy state of no inflammation.

SOCIO-CULTURAL BINOCULARS VIEW OF TELEMEDICINE IN SUB-SAHARAN AFRICA: POTENCY, PROSPECT, DEFECT AND DANGER

Sub-Saharan Africa has experienced unprecedented technological advancement, just like several other regions of the world. This improvement in technology lends credence to the proliferation of android mobile phones, laptops computers and the Internet facilities that enhance interaction on the social media which in turn generates momentous alterations in the ways the residents of the region construct their daily lives. From epidemiological perspective as well as the viewpoint of change and development, via these information technologies, rendering health-related care and services to the residents in the remote places of the region and gaining access to vital information that prompts prevention and control of diseases are now feasible unlike before the advancement. Therefore, telemedicine symbolizes a health innovation in the region. In the light of this, this paper systematically reviewed the extent to which telemedicine has gained acceptance among the residents of the region; and the socio-cultural factors and practices that promote and decelerate the general acceptance of telemedicine in the region. To accomplish the objective, the review was done meta-analytically and meta-synthetically to explore recent relevant studies. The paper discovered that reduction in the cost of gaining access to health information, harnessing online health and medical services, are among the benefits derived from telemedicine while fake online information, impoverished network service delivery, financial incapacity, theft, technical faults, underutilization of the technology devices and cyber-crime are among the factors that militate against wide acceptance of telemedicine in the region.

ASTERACEAE: A TAXONOMICALLY AND MEDICINALLY IMPORTANT SUNFLOWER FAMILY

The Purpose of the research: The study aimed to document the Asteraceae species in the study area. The study also examined the species diversity and medicinally important plants. Data, Materials, and Methodology: The work is based on fresh materials collected during thirty-six field visits to Paba Upazila of Rajshahi district, Bangladesh was carried out from November 2018 to October 2019 to cover the seasonal variations. Plant parts with either flower or fruits collected using traditional herbarium techniques to make voucher specimens for documentation. The results: The result shows in all, 44 species under 35 genera of the family Asteraceae were reported, out of which 40 (90.90%) were used medicinal applications for the treatment of more than 59 diseases. Major findings: The findings of the study that 25% of species were very common, 43.18% were common, 25% species were rare and 6.82% species were very rare in the study area. Mikania cordata (Burm.f.) Robinson is the only climbing species. Blumea laciniata (Roxb.) DC. and Wedelia trilobata (L.) Hitchc. has been reported for the first time in Paba Upazila of Rajshahi. The present study will help in identifying the major Asteraceae species for further investigation and also beneficial to develop the herbal drug development.

General Diaz Process, Industrial Diaz

According to general essential of colorant of azo derivatives and structure, releasing the substitution of the azo components by electron attracting groups produces required activity enables to get blue shades from structures .

Hormonal Response of Gibberellin (Ga3), Grafting and Seasonal Variations on Growth and Yield Parameters on Okra (Abelmoschus Esculentus)

The effect of Gibberellin Hormonal Response and Grafting methods on the Growth and Yield of Okra was investigated, with the aim of inducing variability that could be exploited in the improvement of some quality traits in Okra plants. Gibberellin, grafting and a combination of grafting with Gibberellin) were applied on to the Okra seeds. The seeds of Okra were treated at four different concentrations of Gibberellin (0.1mM, 1.0 mM, 2.0 mM and 0.0 mM as control) after which some of the mutants were grafted using tongue grafting method at seedlings stage. The other set of seeds were not treated with the hormone but were grafted at seedlings stage. The results obtained revealed highly significant difference (P≤ 0.01) in the effects of Gibberellin on survival rates, number of fruits, and fruit weight. Similarly, highly significant differences (P≤0.01) were found between the treatments in Survival rate, except on the number of fruits and fruit weight, where no significant differences exist. More so, significant differences were found in the traits between the seasons except in fruit number. The result showed that Gibberellin and grafting improve important quality traits of Okra. The mutants and grafted Okra could be grown both during the rainy and dry seasons, while 0.1 mM concentration of Gibberellin and grafting improve some important quality traits of Okra that could be utilized for further improvement of Okra. However, the response of Okra to grafting was higher. Based on the findings, the study concluded that, grafting improves some important quality traits of Okra that are of high economic value and possible recommendations that could be made.