scholarly journals Faculty Opinions recommendation of Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron.

2021 ◽  
Author(s):  
William Colmers
Keyword(s):  
Gnrh Neuron

Essential Role of 2-O and N-Sulfation of Heparin on FGFR1 Regulation by Anosmin-1 in GnRH Neuron Migration.

2010 ◽  
pp. P2-133-P2-133
Author(s):  
Youli Hu ◽  
Scott E. Guimond ◽  
Soo-Hyun Kim ◽  
Jeremy E. Turnbull ◽  
Pierre Bouloux
Keyword(s):  
Essential Role ◽  
Gnrh Neuron ◽  
Neuron Migration

scholarly journals Dominant Neuropeptide Cotransmission in Kisspeptin-GABA Regulation of GnRH Neuron Firing Driving Ovulation

2018 ◽  
Vol 38 (28) ◽  
pp. 6310-6322 ◽  
Author(s):  
Richard Piet ◽  
Bruna Kalil ◽  
Tim McLennan ◽  
Robert Porteous ◽  
Katja Czieselsky ◽  
...  
Keyword(s):  
Gnrh Neuron ◽  
Neuron Firing

scholarly journals Prenatal Androgenization Alters the Development of GnRH Neuron and Preoptic Area RNA Transcripts in Female Mice

Endocrinology ◽  
2020 ◽  
Vol 161 (11) ◽  
Author(s):  
Laura L Burger ◽  
Elizabeth R Wagenmaker ◽  
Chayarndorn Phumsatitpong ◽  
David P Olson ◽  
Suzanne M Moenter
Keyword(s):  
Protein Synthesis ◽  
Oxidative Phosphorylation ◽  
Polycystic Ovary ◽  
Affinity Purification ◽  
Developmental Trajectory ◽  
Late Gestation ◽  
Gnrh Neuron ◽  
Altered Expression ◽  
Increased Risk ◽  
Gnrh Neurons

Abstract Polycystic ovary syndrome (PCOS) is the most common form of infertility in women. The causes of PCOS are not yet understood and both genetics and early-life exposure have been considered as candidates. With regard to the latter, circulating androgens are elevated in mid–late gestation in women with PCOS, potentially exposing offspring to elevated androgens in utero; daughters of women with PCOS are at increased risk for developing this disorder. Consistent with these clinical observations, prenatal androgenization (PNA) of several species recapitulates many phenotypes observed in PCOS. There is increasing evidence that symptoms associated with PCOS, including elevated luteinizing hormone (LH) (and presumably gonadotropin-releasing hormone [GnRH]) pulse frequency emerge during the pubertal transition. We utilized translating ribosome affinity purification coupled with ribonucleic acid (RNA) sequencing to examine GnRH neuron messenger RNAs from prepubertal (3 weeks) and adult female control and PNA mice. Prominent in GnRH neurons were transcripts associated with protein synthesis and cellular energetics, in particular oxidative phosphorylation. The GnRH neuron transcript profile was affected more by the transition from prepuberty to adulthood than by PNA treatment; however, PNA did change the developmental trajectory of GnRH neurons. This included families of transcripts related to both protein synthesis and oxidative phosphorylation, which were more prevalent in adults than in prepubertal mice but were blunted in PNA adults. These findings suggest that prenatal androgen exposure can program alterations in the translatome of GnRH neurons, providing a mechanism independent of changes in the genetic code for altered expression.

P-264. Role of cyclic nucleotide phosphodiesterase (PDE) in GnRH secretion from GnRH neuron

1999 ◽  
Vol 14 (Suppl_3) ◽  
pp. 273-273
Author(s):  
M. Taga ◽  
H. Yoshida ◽  
H. Sakakibara ◽  
C. Ohkohchi ◽  
F. Hirahara
Keyword(s):  
Cyclic Nucleotide ◽  
Cyclic Nucleotide Phosphodiesterase ◽  
Gnrh Neuron ◽  
Gnrh Secretion

scholarly journals Insulin Receptor Signaling in the GnRH Neuron Plays a Role in the Abnormal GnRH Pulsatility of Obese Female Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119995 ◽  
Author(s):  
Sara A. DiVall ◽  
Danny Herrera ◽  
Bonnie Sklar ◽  
Sheng Wu ◽  
Fredric Wondisford ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Receptor Signaling ◽  
Gnrh Neuron ◽  
Female Mice ◽  
Obese Female ◽  
Insulin Receptor Signaling

scholarly journals Both Estrogen and Androgen Modify the Response to Activation of Neurokinin-3 and κ-Opioid Receptors in Arcuate Kisspeptin Neurons From Male Mice

Endocrinology ◽  
2015 ◽  
Vol 157 (2) ◽  
pp. 752-763 ◽  
Author(s):  
Kristen A. Ruka ◽  
Laura L. Burger ◽  
Suzanne M. Moenter
Keyword(s):  
Estrogen Receptor ◽  
Firing Pattern ◽  
Pulse Generator ◽  
Brain Slices ◽  
Gonadal Steroids ◽  
Gnrh Neuron ◽  
Male Mice ◽  
Neurokinin B ◽  
Neuron Firing ◽  
Kndy Neurons

Abstract Gonadal steroids regulate the pattern of GnRH secretion. Arcuate kisspeptin (kisspeptin, neurokinin B, and dynorphin [KNDy]) neurons may convey steroid feedback to GnRH neurons. KNDy neurons increase action potential firing upon the activation of neurokinin B receptors (neurokinin-3 receptor [NK3R]) and decrease firing upon the activation of dynorphin receptors (κ-opioid receptor [KOR]). In KNDy neurons from intact vs castrated male mice, NK3R-mediated stimulation is attenuated and KOR-mediated inhibition enhanced, suggesting gonadal secretions are involved. Estradiol suppresses spontaneous GnRH neuron firing in male mice, but the mediators of the effects on firing in KNDy neurons are unknown. We hypothesized the same gonadal steroids affecting GnRH firing pattern would regulate KNDy neuron response to NK3R and KOR agonists. To test this possibility, extracellular recordings were made from KNDy neurons in brain slices from intact, untreated castrated or castrated adult male mice treated in vivo with steroid receptor agonists. As observed previously, the stimulation of KNDy neurons by the NK3R agonist senktide was attenuated in intact vs castrated mice and suppression by dynorphin was enhanced. In contrast to observations of steroid effects on the GnRH neuron firing pattern, both estradiol and DHT suppressed senktide-induced KNDy neuron firing and enhanced the inhibition caused by dynorphin. An estrogen receptor-α agonist but not an estrogen receptor-β agonist mimicked the effects of estradiol on NK3R activation. These observations suggest the steroid modulation of responses to activation of NK3R and KOR as mechanisms for negative feedback in KNDy neurons and support the contribution of these neurons to steroid-sensitive elements of a GnRH pulse generator.

scholarly journals Clinical Manifestations of Impaired GnRH Neuron Development and Function

Neurosignals ◽  
2008 ◽  
Vol 16 (2-3) ◽  
pp. 165-182 ◽  
Author(s):  
Hyung-Goo Kim ◽  
Balasubramanian Bhagavath ◽  
Lawrence C. Layman
Keyword(s):  
Clinical Manifestations ◽  
Gnrh Neuron ◽  
Neuron Development ◽  
And Function
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