scholarly journals Analgesic Efficacy of Cordia Verbenacea-based Gel in the Reduction of Pain Associated with Use of Separator Elastics/ Eficácia Analgésica do Gel à base de Cordia Verbenacea na Redução de Tinta Associada ao Uso de Elásticos Separadores

2021 ◽  
Vol 7 (6) ◽  
pp. 63855-63868
Author(s):  
Itauana Vettorello ◽  
Daniele Michelin Paganotte ◽  
Adilson Sartorato ◽  
Vivian Fernandes Furletti de Góes ◽  
Andrea Aparecida de Aro ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Analgesic Efficacy ◽  
Topical Administration ◽  
Burning Sensation ◽  
The Other ◽  
Analog Scale ◽  
Double Blind ◽  
Reduction Of Pain ◽  
Blinded Manner ◽  
Experimental Side

Introduction: In Orthodontics separator elastics are used to create space for inserting the bands. This causes pain. Phytotherapy has been promising as a therapy. Objective. This double blind randomized clinical trial evaluated the level of pain due to the use of elastic separator (SE) after intraoral topical administration of Cordia verbenacea gel (CV). Methods. 50 volunteers received the SE on the mesial and distal surfaces of the maxillary first molars. In a blinded manner, 0.5 g of the gel was used in one hemi-arch, and placebo in the other hemi-arch on the free gingival margin of the first molar, every 8 hours, for 3 days. Pain was measured on a visual analog scale (VAS), before insertion of the SE (t0), immediately after (t1) and every hour after the following applications. Sensory analysis of the was performed for effects of taste and burning. Wilcoxon (comparison between sides) and Friedman and Nemenyi tests were performed for comparisons between times (α=0.05). Results. The pain was lower on the side that received the phytotherapeutic gel, from the first application until before the removal of the elastic (p 0.05).  As regards the burning sensation, the experimental side had higher scores and 20% of the subjects considered the CV gel had an unpleasant taste. It was concluded that the use of the intrabucal topic of CV has an analgesic potential for pain resulting from the insertion of SE.

scholarly journals Evaluation on immediate analgesic efficacy and safety of Kai-Hou-Jian spray (children’s type) in treating sore throat caused by acute pharyngitis and tonsillitis in children: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yan-ning Ma ◽  
Cheng-liang Zhong ◽  
Si-yuan Hu ◽  
Qiu-han Cai ◽  
Sheng-xuan Guo
Keyword(s):  
Clinical Trial ◽  
Sore Throat ◽  
Controlled Trial ◽  
Analgesic Efficacy ◽  
Effective Rate ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Acute Pharyngitis ◽  
Randomized Controlled ◽  
Parallel Group

Abstract Background Acute pharyngitis and tonsillitis are common respiratory diseases for which children seek medical care. Their main clinical manifestation is sore throat which interferes with patients’ quality of life. However, there is no proven effective or safe method to treat it. It is necessary to find an excellent strategy to reduce sore throat and reduce the burden of acute illness. We designed the randomized controlled trial with the characteristics of traditional Chinese medicine (TCM) to determine the clinical positioning of Kai-Hou-Jian spray (children’s type) (KHJS) through evidence-based research. This trial aims to evaluate the immediate analgesic efficacy of KHJS on sore throat caused by acute pharyngitis and tonsillitis (wind-heat syndrome/heat exuberance in lung and stomach syndrome) in children and to observe its safety. Methods/design This is a prospective, multicenter, randomized, double-blind, parallel-group, placebo-controlled trial. It will include 240 children with acute pharyngitis/tonsillitis from 7 study sites across China. All participants are randomly assigned to two parallel treatment groups, one with KHJS and the other with placebo sprays, for 5 consecutive days. The primary outcome is the time of analgesic onset. Secondary outcomes include duration of analgesic effect, area under time curve of 0–3 h Wong-Baker FACES Pain Rating Scale (WBS) score (AUC0-3 h), rate of analgesic onset, rate of disappearance of sore throat, changes of WBS score (in days), effective rate of pharyngeal signs, and effective rate of TCM syndrome. The incidence of adverse events during the trial is the primary safety outcome. In addition, vital signs and laboratory tests before and after medication are monitored. Discussion To our knowledge, this will be the first clinical trial to explore the immediate analgesic efficacy of a Chinese patent medicine spray for acute pharyngitis/tonsillitis induced sore throat in children in a multicenter, randomized, double-blinded, parallel-group, placebo-controlled manner. Not only might it prove the efficacy and safety of KHJS in the treatment of sore throat caused by acute pharyngitis/tonsillitis in children, but it might also provide evidence for the treatment of acute sore throat with Chinese herbal medicine. Trial registration A multicenter, randomized, double-blind, very low-dose, parallel controlled trial for the immediate analgesic effect and safety of Kai-Hou- Jian spray (children's type) in the treatment of sore throat caused by acute pharyngitis and tonsillitis in children. Chinese Clinical Trial Registry ChiCTR2000031599. Registered on 5 April 2020

A Double-Blind Comparative Clinical Trial of Floctafenine and Four Other Analgesics Conducted in General Practice

1976 ◽  
Vol 4 (3) ◽  
pp. 179-182 ◽  
Author(s):  
D M Lomas ◽  
J Gay ◽  
R N Midha ◽  
D L Postlethwaite
Keyword(s):  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Analgesic Effect ◽  
Rank Order ◽  
Controlled Trial ◽  
The Other ◽  
Double Blind ◽  
Comparative Clinical Trial

Three hundred and twelve patients suffering from painful conditions were admitted to a multicentre, double-blind controlled trial, conducted in general practice in which five analgesics—floctafenine (Idarac), paracetamol, aspirin, dihydrocodeine and pentazocine—were compared. Overall ratings of analgesic effect placed floctafenine first in rank order. Floctafenine was statistically significantly superior in effect to pentazocine but not to the other three agents as far as doctor ratings were concerned; and superior to both pentazocine and dihydrocodeine in the opinion of patients. Fewer patients experienced side-effects on floctafenine than on the other four analgesics and this difference between floctafenine and pentazocine, and floctafenine and dihydrocodeine was statistically significant.

Effectiveness of Aromatherapy for Relief of Pain, Nausea, and Vomiting after Percutaneous Nephrolithotomy: A Randomized Controlled Trial

2020 ◽  
Vol 27 (6) ◽  
pp. 440-448
Author(s):  
Mojdeh Amirhosseini ◽  
Mahlagha Dehghan ◽  
Parvin Mangolian Shahrbabaki ◽  
Hamid Pakmanesh
Keyword(s):  
Clinical Trial ◽  
Randomized Controlled Trial ◽  
Percutaneous Nephrolithotomy ◽  
Complementary Therapies ◽  
Controlled Trial ◽  
The Other ◽  
Nausea And Vomiting ◽  
Control Group ◽  
Analog Scale ◽  
Randomized Controlled

<b><i>Background:</i></b> Postoperative pain, nausea, and vomiting are common side effects of percutaneous nephrolithotomy. Nowadays, non-pharmacological and complementary therapies have been noticed. Therefore, a study was conducted to determine the effectiveness of lavender and clary sage on the pain, nausea, and vomiting after percutaneous nephrolithotomy. <b><i>Methods:</i></b> This is a randomized clinical trial study on 79 patients undergoing percutaneous nephrolithotomy. Patients were randomly divided into three groups of lavender aromatherapy (<i>n</i> = 27), clary sage aromatherapy (<i>n</i> = 26), and a control group (<i>n</i> = 26). Each of the intervention groups received the inhalation aromatherapy immediately and 3 and 6 h after the operation. Pain, nausea, and emetic episodes in patients of the three groups were measured before the intervention and 30 min after each intervention using a visual analog scale and checklist. <b><i>Results:</i></b> Pain decreased significantly in the clary sage aromatherapy group. Nausea had a downward trend in the two groups of aromatherapy. The lavender aromatherapy group had the lowest incidence of emetic episodes compared to the other groups. <b><i>Conclusion:</i></b> Regarding the annoying pain, nausea, and vomiting after percutaneous nephrolithotomy for patients, and taking into account the complications of drug therapy, the use of complementary non-pharmacological methods can help increase the comfort of patients.

scholarly journals Analgesic efficacy of cerebral and peripheral electrical stimulation in chronic nonspecific low back pain: a randomized, double-blind, factorial clinical trial

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Fuad Ahmad Hazime ◽  
Diego Galace de Freitas ◽  
Renan Lima Monteiro ◽  
Rafaela Lasso Maretto ◽  
Nilza Aparecida de Almeida Carvalho ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Electrical Stimulation ◽  
Low Back Pain ◽  
Back Pain ◽  
Analgesic Efficacy ◽  
Low Back ◽  
Double Blind ◽  
Peripheral Electrical Stimulation

Homoeopathic treatment of malaria in Ghana

1996 ◽  
Vol 85 (02) ◽  
pp. 66-70 ◽  
Author(s):  
Veronique M.A. Van Erp ◽  
Martien Brands
Keyword(s):  
Clinical Trial ◽  
Clinical Improvement ◽  
Open Study ◽  
Northern Region ◽  
The Other ◽  
Double Blind ◽  
Double Blind Clinical Trial

AbstractIn a clinic in Tamale (Ghana, Northern Region) patients with malaria were treated with homoeopathic drugs in an open study (n=75), of whom 90.7% (n=68) showed clinical improvement.Subsequently in a randomized, double-blind, clinical trial, one group (n=30) received homoeopathic drugs, of which 83.3% improved clinically, whereas the other group (n=25) received chloroquine with improvement in 72% patients. This difference is not statistically significant due to the limited samples. The results do, however, suggest further research with larger groups.

scholarly journals Evaluation of the Effectiveness of the Iralvex Gel on the Recurrent Aphthous Stomatitis Management

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Heidar Khademi ◽  
Pedram Iranmanesh ◽  
Ali Moeini ◽  
Atefeh Tavangar
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Complete Healing ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
The Other ◽  
Definitive Treatment ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Pain Duration

Introduction. As there is no definitive treatment for the recurrent aphthous stomatitis (RAS), most of the available therapies aim at decreasing pain and discomfort. The aim of this study was to investigate the effectiveness of the Iralvex gel on the RAS management. Material and Methods. In this double-blind and placebo-controlled clinical trial study, twenty patients were treated with the Iralvex gel and the other twenty patients were treated with placebo. In every participant complete healing of lesions, pain duration, and intensity were evaluated. Data were analyzed by independent t-test and analysis of variance. Results. Pain was relieved after 6.10 ± 0.29 days in the Iralvex group in comparison to 8.00 ± 0.33 days in the placebo group (P value ≤0.001). Complete remission in the Iralvex group was after 6.80 ± 0.27 days and 10.20 ± 0.42 days in the placebo group (P value ≤ 0.001). Furthermore, significant differences in the pain intensity between Iralvex and placebo group measured on days 1, 3, and 5 were obtained (P value ≤ 0.01). Conclusion. The results of this study show that Iralvex gel is effective and cheap remedy for treatment of RAS without side effects. This trial is registered with IRCT201207253251N3.

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