O que sabemos sobre o uso de pele de tilápia na cicatrização de feridas? revisão integrativa / What do we know about the use of Tilapia skin in wound healing? integrative review

Wound healing is a perfectly coordinated cascade of cellular, molecular, and biochemical events which interact in tissue reconstitution. Chronic diseases such as pressure ulcers (PU) and diabetes mellitus (DM) are considered risk factors for wound healing. Patients with such diseases often have higher sepsis, infection, and complication rates, since they have revascularization inhibition and low growth factor expression. Thus, latex biomembrane (LBM), a biocompatible material, derived from the latex of the rubber tree (Hevea brasiliensis) appears to create tendencies as an angiogenic-inducing tissue healing agent and as biomaterial, resulting from its structural qualities and its low cost when compared to conventional treatments. Therefore, this work aims at summarizing the results, experiments, and scientific findings that certify or recommend the use of LBM as a new technique to be applied effectively in the treatment of wounds. An integrative review was held in the BIREME, LILACS, Burns, MEDLINE, PubMed, and SciELO databases, from 2000 to 2016, using the following descriptors: “healing,” “diabetes mellitus,” “wounds,” and “latex membrane.” As a result, 600 experiments (out of 612) presented satisfactory results; however, 33% of the cases received explicit recommendations, 11% required more studies on the subjects, and 1% was denied. On the other hand, half of the studies did not expressly endorse its use, despite presenting satisfactory results. The LBM was characterized as a good therapeutic alternative in cases of wounds, including chronic diseases, such as diabetes mellitus and PU, due to its relevant potential for wound healing stimulation, acceleration of cell tissue mending and revascularization, or the reestablishment of angiogenic functions (creation of new blood vessels). The LBM was also confirmed to be safe as a biocompatible material whose structural qualities (elasticity, adaptability, impermeability, and possibility of suture), devoid of toxicity, allowed interaction between tissues and presented no hypersensitivity inducer and no antimicrobial effect.

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Use of amniotic membrane in wound healing: integrative review / Uso da membrana amniótica na cicatrização de feridas: revisão integrativa

Revista de Pesquisa Cuidado é Fundamental Online ◽

10.9789/2175-5361.rpcfo.v13.9249 ◽

2021 ◽

Vol 13 ◽

pp. 1361-1366

Author(s):

Kauan Gustavo De Carvalho ◽

Karla Joelma Bezerra Cunha ◽

Nanielle Silva Barbosa ◽

Ana Caroliny de Barros Soares Lima ◽

Jefferson Abraão Caetano Lira ◽

...

Keyword(s):

Wound Healing ◽

Amniotic Membrane ◽

Allied Health ◽

Medical Literature ◽

Integrative Review ◽

Literature Analysis ◽

Health Literature

Objetivo: identificar na literatura o uso da membrana amniótica na cicatrização de feridas. Método: revisão integrativa onde aplicou-se os descritores: ‘’feridas’’, ‘’membrana amniótica’’ e ‘’cicatrização’’ às bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde, Medical Literature Analysis and Retrieval Sistem Online e Cummulative Index to Nursing and Allied Health Literature, entre Janeiro e Fevereiro de 2019. Resultados: foram selecionados 18 artigos os quais embasaram a construção de duas categorias temáticas. Evidenciou-se que a membrana aminiótica possui capacidade para diminuir o exsudato e adesões, reduzir a dor local e agir como um substrato para o crescimento de tecidos. Conclusão: a membrana amniótica constitui-se alternativa eficaz para o tratamento de feridas. Faz-se necessário o desenvolvimento de estudos mais aprofundados a fim de ampliar o conhecimento da equipe da saúde e contribuir para o avanço e fortalecimento de práticas em estomaterapia.

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Nutritional therapy and wound healing in pressure injury situations: an integrative review

Nutrire ◽

10.1186/s41110-021-00147-3 ◽

2021 ◽

Vol 46 (2) ◽

Author(s):

Guilherme Vasques Segalla ◽

Sarah Trindade Teixeira ◽

Marcelo Macedo Rogero

Keyword(s):

Wound Healing ◽

Nutritional Therapy ◽

Integrative Review ◽

Pressure Injury

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ultrastructural process of intestinal wound healing

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100141494 ◽

1995 ◽

Vol 53 ◽

pp. 1024-1025

Author(s):

Rick L. Vaughn ◽

Shailendra K. Saxena ◽

John G. Sharp

Keyword(s):

Wound Healing ◽

Epithelial Cells ◽

Smooth Muscles ◽

Microscopic Level ◽

Light Microscopic Level ◽

Ileal Mucosa ◽

Wound Model ◽

Serosal Surface ◽

Complex Process ◽

Orderly Fashion

We have developed an intestinal wound model that includes surgical construction of an ileo-cecal patch to study the complex process of intestinal wound healing. This allows approximation of ileal mucosa to the cecal serosa and facilitates regeneration of ileal mucosa onto the serosal surface of the cecum. The regeneration of ileal mucosa can then be evaluated at different times. The wound model also allows us to determine the rate of intestinal regeneration for a known size of intestinal wound and can be compared in different situations (e.g. with and without EGF and Peyer’s patches).At the light microscopic level it appeared that epithelial cells involved in regeneration of ileal mucosa originated from the enlarged crypts adjacent to the intestinal wound and migrated in an orderly fashion onto the serosal surface of the cecum. The migrating epithelial cells later formed crypts and villi by the process of invagination and evagination respectively. There were also signs of proliferation of smooth muscles underneath the migratory epithelial cells.

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Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

Clinical Science ◽

10.1042/cs20191102 ◽

2020 ◽

Vol 134 (16) ◽

pp. 2189-2201

Author(s):

Jessica P.E. Davis ◽

Stephen H. Caldwell

Keyword(s):

Wound Healing ◽

Liver Disease ◽

Hepatic Fibrosis ◽

Cell Activation ◽

Stellate Cell ◽

Factor Xa ◽

Clinical Trial Data ◽

Chronic Liver ◽

Healing Response ◽

Wound Healing Response

Abstract Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.

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