Evidence in Practice of Tissue Healing with Latex Biomembrane: Integrative Review

Wound healing is a perfectly coordinated cascade of cellular, molecular, and biochemical events which interact in tissue reconstitution. Chronic diseases such as pressure ulcers (PU) and diabetes mellitus (DM) are considered risk factors for wound healing. Patients with such diseases often have higher sepsis, infection, and complication rates, since they have revascularization inhibition and low growth factor expression. Thus, latex biomembrane (LBM), a biocompatible material, derived from the latex of the rubber tree (Hevea brasiliensis) appears to create tendencies as an angiogenic-inducing tissue healing agent and as biomaterial, resulting from its structural qualities and its low cost when compared to conventional treatments. Therefore, this work aims at summarizing the results, experiments, and scientific findings that certify or recommend the use of LBM as a new technique to be applied effectively in the treatment of wounds. An integrative review was held in the BIREME, LILACS, Burns, MEDLINE, PubMed, and SciELO databases, from 2000 to 2016, using the following descriptors: “healing,” “diabetes mellitus,” “wounds,” and “latex membrane.” As a result, 600 experiments (out of 612) presented satisfactory results; however, 33% of the cases received explicit recommendations, 11% required more studies on the subjects, and 1% was denied. On the other hand, half of the studies did not expressly endorse its use, despite presenting satisfactory results. The LBM was characterized as a good therapeutic alternative in cases of wounds, including chronic diseases, such as diabetes mellitus and PU, due to its relevant potential for wound healing stimulation, acceleration of cell tissue mending and revascularization, or the reestablishment of angiogenic functions (creation of new blood vessels). The LBM was also confirmed to be safe as a biocompatible material whose structural qualities (elasticity, adaptability, impermeability, and possibility of suture), devoid of toxicity, allowed interaction between tissues and presented no hypersensitivity inducer and no antimicrobial effect.

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Short Report: The Moisture Balance with Aloe Vera Gel in Diabetic Wound Healing

International Journal of Nursing and Health Services (IJNHS) ◽

10.35654/ijnhs.v1i1.9 ◽

2018 ◽

Vol 1 (1) ◽

pp. 21-23

Author(s):

Fahrianto Selamet ◽

Andi Mayasari Usman ◽

Rian Adi Pamungkas

Keyword(s):

Diabetes Mellitus ◽

Wound Healing ◽

Wound Care ◽

Aloe Vera ◽

Foot Ulcer ◽

Diabetic Foot Ulcer ◽

Short Report ◽

Bacterial Reduction ◽

Moisture Balance ◽

Patients With Diabetes

Diabetic foot ulcer (DF) is a chronic complication of diabetes mellitus (DM), which impact on the morbidity, mortality and quality of patients’ lives.Of those patients with diabetes mellitus, approximately 15% to 25% developed to the foot ulcer. Beside has the infection and debridement of devitalized tissue downloading; the moisture imbalance becomes the factors of recalcitrant to healing. Moist wound healing is often contraindicated to the non-healable wounds. While wound care involves the debridement, bacterial reduction, and moisture balance in order to achieve the good granulation of the tissue development and adequate blood supply.

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Mutations of mtDNA in some vascular and metabolic diseases

Current Pharmaceutical Design ◽

10.2174/1381612826999200820162154 ◽

2020 ◽

Vol 26 ◽

Author(s):

Margarita A. Sazonova ◽

Anastasia I. Ryzhkova ◽

Vasily V. Sinyov ◽

Marina D. Sazonova ◽

Tatiana V. Kirichenko ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

Chronic Diseases ◽

Metabolic Diseases ◽

Present Review ◽

Mtdna Mutations

Background: The present review article considers some chronic diseases of vascular and metabolic genesis, the causes of which may be mitochondrial dysfunction. Very often, in the long course of the disease, complications may occur, leading to myocardial infarction or ischemic stroke and as a result, death.In particular, a large percentage of human deaths nowadays belongs to cardiovascular diseases such as coronary heart disease (CHD), arterial hypertension, cardiomyopathies and type 2 diabetes mellitus. Objective: The aim of the present review was the analysis of literature sources, devoted to an investigation of a link of mitochondrial DNA mutations with chronic diseases of vascular and metabolic genesis, Results: The analysis of literature indicates the association of the mitochondrial genome mutations with coronary heart disease, type 2 diabetes mellitus, hypertension and various types of cardiomyopathies. Conclusion: The detected mutations can be used to analyze the predisposition to chronic diseases of vascular and metabolic genesis. They can also be used to create molecular-cell models necessary to evaluate the effectiveness of drugs developed for treatment of these pathologies. MtDNA mutations associated withthe absence of diseases of vascular and metabolic genesis could be potential candidates for gene therapy of diseases of vascular and metabolic genesis.

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Cigarette smoking, type 2 diabetes mellitus, and glucagon-like peptide-1 receptor agonists as a potential treatment for smokers with diabetes: An integrative review

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2019.01.033 ◽

2019 ◽

Vol 149 ◽

pp. 78-88 ◽

Cited By ~ 2

Author(s):

Luba Yammine ◽

Thomas R. Kosten ◽

Maria Pimenova ◽

Joy M. Schmitz

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cigarette Smoking ◽

Integrative Review ◽

Potential Treatment ◽

Receptor Agonists ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1

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Low Cost Negative Pressure Wound Healing Device System

Research Journal of Applied Sciences Engineering and Technology ◽

10.19026/rjaset.14.3989 ◽

2017 ◽

Vol 14 (2) ◽

pp. 56-60

Author(s):

Tian-Swee Tan ◽

Kee-Gang Ng ◽

Kasim Johari ◽

Kah-Meng Leong ◽

Zaharil Arman ◽

...

Keyword(s):

Wound Healing ◽

Negative Pressure ◽

Low Cost

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Theoretical and contextual considerations for self-management strategies of children and adolescents with chronic diseases: An integrative review

Journal of Child Health Care ◽

10.1177/13674935211013697 ◽

2021 ◽

pp. 136749352110136

Author(s):

Logan J Camp-Spivey ◽

Ayaba Logan ◽

Michelle Nichols

Keyword(s):

Children And Adolescents ◽

Chronic Diseases ◽

Management Strategies ◽

Healthcare Providers ◽

Integrative Review ◽

Self Management ◽

Intervention Delivery ◽

Management Interventions ◽

Technological Platforms ◽

Management Behaviors

The primary aim of this integrative review was to critically evaluate and synthesize published, peer-reviewed research to better understand self-management strategies of children and adolescents with chronic diseases. This review was guided by Whittemore and Knafl’s methodological framework. The Pediatric Self-management Model provided the theoretical framework for understanding how self-management behaviors operate within the domains of individual, family, community, and healthcare systems. In June 2019, the electronic databases of EBSCOhost, PubMed, and Scopus, along with reference lists of applicable studies, were searched for appropriate publications. The initial searches yielded 920 citations. Of these, 11 studies met inclusion criteria. A key finding was that involving children and adolescents in the design and delivery phases of interventions was most effective in improving self-management when the interventions did not outweigh cognitive ability or maturity level. In addition, incorporating self-efficacy promotion into self-management interventions may lead to greater sense of responsibility and improved health outcomes. In terms of intervention delivery of self-management strategies, the use of technological platforms and devices was revealed as a promising avenue for youth. A final implication was the importance of family members, peers, and healthcare providers in supporting children and adolescents in adopting self-management behaviors.

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Silver diamine fluoride for managing carious lesions: A literature review

Archives of Dental Research ◽

10.18231/j.adr.2021.020 ◽

2021 ◽

Vol 11 (2) ◽

pp. 118-122

Author(s):

Dishika Iswar ◽

Arun Kumar Sajjanar ◽

Milind Wasnik ◽

Niharika Gawod ◽

Partima Kolekar ◽

...

Keyword(s):

Dental Caries ◽

Dental Health ◽

Low Cost ◽

Invasive Procedure ◽

Antimicrobial Effect ◽

Permanent Teeth ◽

Silver Diamine Fluoride ◽

The Us ◽

Socioeconomical Status ◽

Silver Compounds

Though the prevalence and the severity of dental caries is decreased in past few years, still children from low socioeconomical status in many industrialized or developing countries are still suffering from ill-effects of dental caries. The antimicrobial effect of silver compounds has been proven by the 100-year-old application of silver compounds. Silver diamine fluoride (SDF) has been used to arrest dental caries during 1970s in Japan, but it was not exposed much to other parts of the world. Today in many countries a 38% (44,800 ppm fluoride) SDF solution is commonly used to arrest caries and also to reduce hypersensitivity in primary and permanent teeth. Application of SDF to arrest dental caries is non-invasive procedure and is quick and simple to use. Reports of available studies showed that there is no severe pulpal damage after SDF application. However, it has some drawbacks like black discoloration of the carious teeth and an unpleasant metallic taste. But, low cost of SDF and its simplicity in application suggest that it is an appropriate agent for use in community dental health programme. Thus, SDF appears to meet the criteria of both the WHO Millennium Goals and the US Institute of Medicine’s criteria for 21st century medical care, that is, it is a safe, effective, efficient, and equitable caries preventive agent.

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SGLT2 inhibitors: the future for treatment of type 2 diabetes mellitus and other chronic diseases

Diabetologia ◽

10.1007/s00125-018-4678-z ◽

2018 ◽

Vol 61 (10) ◽

pp. 2134-2139 ◽

Cited By ~ 20

Author(s):

Christoph Wanner ◽

Nikolaus Marx

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Chronic Diseases ◽

Sglt2 Inhibitors ◽

The Future

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Impact of bevacizumab chemotherapy on craniotomy wound healing

Journal of Neurosurgery ◽

10.3171/2010.10.jns101042 ◽

2011 ◽

Vol 114 (6) ◽

pp. 1609-1616 ◽

Cited By ~ 59

Author(s):

Aaron J. Clark ◽

Nicholas A. Butowski ◽

Susan M. Chang ◽

Michael D. Prados ◽

Jennifer Clarke ◽

...

Keyword(s):

Wound Healing ◽

Recurrent Glioblastoma ◽

Csf Leak ◽

Categorical Variables ◽

Complication Rates ◽

Phase Ii Trials ◽

Impaired Wound Healing ◽

The Third ◽

Impaired Healing ◽

Bevacizumab Treatment

Object The FDA approval of bevacizumab for recurrent glioblastoma has resulted in its increased use in this patient population. Phase II trials reported 4%–6% impaired wound healing for bevacizumab initiated postoperatively. The effect of preoperative bevacizumab on subsequent craniotomy healing has not been addressed. Methods The authors retrospectively reviewed the cases of patients who underwent craniotomy for recurrent glioblastoma between 2005 and 2009, evaluating bevacizumab therapy/duration and healing complications (dehiscence, pseudomeningocele, CSF leak, and wound/bone infection). The Wilcoxon rank-sum test and Kruskal-Wallis test were used to compare continuous variables between groups. The Fisher exact test was used to assess for an association between categorical variables, including the comparison of wound-healing complication rates. Logistic regression models were used to estimate odds ratios of wound-healing complications while adjusting for baseline variables. Results Two hundred nine patients underwent a second craniotomy (161 patients) or third craniotomy (48 patients) for recurrent glioblastoma. Twenty-six individuals (12%) developed wound-healing complications. One hundred sixty-eight patients received no bevacizumab, 23 received preoperative bevacizumab, and 18 received postoperative bevacizumab. Significantly more patients receiving preoperative bevacizumab developed healing complications (35%) than non–bevacizumab-treated patients (10.0%, p = 0.004). Postoperative bevacizumab was associated with 6% impaired healing, not significantly different from non–bevacizumab-treated controls (p = 1.0). Preoperative bevacizumab treatment duration (weeks) did not influence healing (OR 0.98, p = 0.55). More healing complications occurred in patients receiving preoperative bevacizumab than in non–bevacizumab-treated controls before the third craniotomy (44% vs 9%, p = 0.03). Conclusions Although subject to the limitations of a retrospective study, we demonstrate that preoperative bevacizumab treatment resulted in impaired healing after a second and third craniotomy, compared with minimal effect of postoperative bevacizumab. This effect is more striking for the third craniotomy and for a shorter delay between bevacizumab and surgery. These complications should be acknowledged as increased bevacizumab use results in more post–bevacizumab-treated patients in whom surgery for recurrent glioblastoma is considered. Based on these results, the authors recommend performing repeated craniotomy more than 28 days after last administered dose of bevacizumab whenever possible.

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