The frequency of cytogenetic abnormalities in idiopathic oligospermia and azoospermia infertile men in Chaharmahal and Bakhtiari province: a cross-sectional study

Background and aims: Infertility is one of the main health issues in families worldwide. In addition, there is a complex correlation between genetics and infertility and chromosomal abnormalities are found in 8% of infertile males. The aim of this study was to determine the frequency of cytogenetic abnormalities among idiopathic oligospermia and azoospermia infertile men who were treated in Chaharmahal and Bakhtiari province. Methods: In this cross-sectional study, the records of a total of 100 participants were evaluated retrospectively. The patients who were under careful physical and para-clinical (i.e., hormonal, ultrasound, and spermiogeram) examinations were enrolled in the study. Chromosomal analysis was carried out on the cultures of peripheral blood lymphocytes by Giemsa (G) banding. Eventually, 10 well-spread metaphases were analyzed by G-banding. Result: The chromosome abnormality frequency, the numerical type, and the structural type were 13%, 3%, and 10%, respectively. Among patients with azoospermia, two cases had Klinefelter syndrome with karyotype. Conclusion: This study demonstrated that structural abnormalities are more prevalent than numerical abnormalities in infertile men who were treated in Chaharmahal and Bakhtiari province. This indicates the importance of cytogenetic examination and the relevance of its achievements to the patient’s management in infertility clinics. Therefore, the cytogenetic test is proposed for infertile men, in particular in those who endure azoospermia.

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Clinico-Hematological and cytogenetic spectrum of adult myelodysplastic syndrome The first retrospective cross-sectional study in Iranian patients

10.21203/rs.3.rs-249637/v1 ◽

2021 ◽

Author(s):

Mostafa Paridar ◽

Kazem Zibara ◽

Seyed Esmaeil Ahmadi ◽

Abbas Khosravi ◽

Maral Soleymani ◽

...

Keyword(s):

Myelodysplastic Syndrome ◽

Cross Sectional Study ◽

Cytogenetic Abnormality ◽

Sectional Study ◽

Trisomy 8 ◽

Cross Sectional ◽

Iron Storage ◽

Monosomy 7 ◽

Female Ratio ◽

Cytogenetic Abnormalities

Abstract Background Myelodysplastic syndrome (MDS), a heterogeneous group of hematopoietic malignancy, has been shown to present different cytogenetic abnormalities, risk factors, and clinico-hematological features in different populations and geographic areas. Herein, we determined the cytogenetic spectrum and clinico-hematological features of Iranian MDS patients for the first time. Methods This prospective cross-sectional study was conducted on 103 patients with MDS in Ahvaz, southwest of Iran, from 2014 to 2018. Clinical presentations, complete blood counts (CBC), and bone marrow (BM) biopsy samples were assessed. Perls' staining was used to evaluate BM iron storage. The cytogenetic evaluation was performed using the conventional G banding method on the BM. Results Patients’ median age was 62.3 (ranged from 50–76), and the majority were male (72.8%). The most common clinical symptom at the time of admission was fatigue (n = 33) followed by pallor (n = 27). The most common subgroup was MDS-Multi Lineage Dysplasia (MDS-MLD) (n = 38, 36.8%), followed by MDS-Single Lineage Dysplasia (MDS-SLD) (n = 28, 18.4%). A normal karyotype was observed in 59 patients (57.3%), while 44 patients (42.7%) had cytogenetic abnormalities. Trisomy 8 (+ 8) was the most common cytogenetic abnormality (n = 14) followed by dell 17p (n = 9) and monosomy 7 (-7) (n = 7). Twelve patients (11.65 %) were transformed to AML. Conclusion Our data betokened that among our MDS patients, Trisomy 8 is the predominant cytogenetic abnormality, and MDS-MLD and MDS-SLD are the most common of subtypes. Noteworthy, the male: female ratio was slightly higher in Iran than in previous reports from other parts of the world. Our study is the first report of the clinical, hematological, and cytogenetic spectrum of MDS patients in Iran

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Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017

Reproductive Biology and Endocrinology ◽

10.1186/s12958-019-0551-2 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 1

Author(s):

W. N. Li ◽

M. M. Jia ◽

Y. Q. Peng ◽

R. Ding ◽

L. Q. Fan ◽

...

Keyword(s):

Semen Quality ◽

Sperm Count ◽

Sperm Concentration ◽

Cross Sectional Study ◽

Semen Parameters ◽

Sectional Study ◽

Joinpoint Regression ◽

Cross Sectional ◽

Progressive Motility ◽

Infertile Men

Abstract Background The aim of this study was to provide information on the semen quality pattern of infertile men and age thresholds for semen parameters in China. Methods This was a retrospective cross-sectional study investigating 71,623 infertile men from the Reproductive and Genetic Hospital of CITIC Xiangya in Hunan, China, from 2011 to 2017. The Kruskal-Wallis test, Mann-Kendall test, linear regression model and joinpoint regression were used. Results Although erratic changes were observed in the median semen parameters (sperm concentration 40.1–52.1 × 106/ml, total sperm count 117.8–153.1 × 106, sperm progressive motility 33.4–38.1%) during the 7 years of observation, no significant decrease in semen quality was found, and 47.88% of infertile men showed normal semen parameters according to the World Health Organization (WHO) criteria. According to the joinpoint regression analysis, sperm progressive motility appeared to decrease earlier than the sperm concentration and total sperm count (at 28, 58, and 42 years of age, respectively). Conclusions There is no evidence of a deterioration in semen quality among infertile men in Hunan, China. Semen parameters decreased with increasing age, with turning points noted at different ages. Semen parameters are not absolute evidence for the assessment of male fertility potential. Therefore, we believe that, among semen parameters, the sperm concentration is the best predictor of fertility for ART, followed by motility. Decreased sperm motility may affect natural pregnancy, but it is not necessary for successful IVF.

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The impact of semen infections over sperm parameters in primary infertile men - results from a real life, cross-sectional study

Fertility and Sterility ◽

10.1016/j.fertnstert.2018.07.840 ◽

2018 ◽

Vol 110 (4) ◽

pp. e299

Author(s):

F. Pederzoli ◽

E. Ventimiglia ◽

P. Capogrosso ◽

L. Boeri ◽

W. Cazzaniga ◽

...

Keyword(s):

Real Life ◽

Cross Sectional Study ◽

Sperm Parameters ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Men ◽

The Impact

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Serum albumin levels are associated with sex steroids hormones and sperm concentration impairment in primary infertile men – results of a cross-sectional study

European Urology Supplements ◽

10.1016/s1569-9056(19)33777-7 ◽

2019 ◽

Vol 18 (9) ◽

pp. e3333-e3334

Author(s):

L. Boeri ◽

P. Capogrosso ◽

E. Ventimiglia ◽

W. Cazzaniga ◽

E. Pozzi ◽

...

Keyword(s):

Serum Albumin ◽

Sex Steroids ◽

Sperm Concentration ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Men

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Dietary Antioxidant Intake in Relation to Semen Quality Parameters in Infertile Men: a Cross-Sectional Study

Clinical Nutrition Research ◽

10.7762/cnr.2019.8.3.229 ◽

2019 ◽

Vol 8 (3) ◽

pp. 229

Author(s):

Mehran Rahimlou ◽

Sara Sohaei ◽

Mohammadhossein Nasr-Esfahani ◽

Mehran Nouri

Keyword(s):

Semen Quality ◽

Cross Sectional Study ◽

Quality Parameters ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Men ◽

Dietary Antioxidant ◽

Antioxidant Intake

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The association between animal flesh foods consumption and semen parameters among infertile Iranian men: a cross-sectional study

Nutrition Journal ◽

10.1186/s12937-020-00633-w ◽

2020 ◽

Vol 19 (1) ◽

Author(s):

Reza Ghiasvand ◽

Laleh Dehghan Marvast ◽

Seyyed Payam Shariatpanahi ◽

Makan Pourmasoumi ◽

Cain C. T. Clark ◽

...

Keyword(s):

Quality Indicators ◽

Semen Quality ◽

Cross Sectional Study ◽

Red Meat ◽

Fish Intake ◽

Sectional Study ◽

Cross Sectional ◽

Fresh Fish ◽

Infertile Men ◽

Canned Fish

Abstract Background Previous studies have demonstrated the association between dietary patterns and semen quality indicators, but research on the possible association between animal flesh foods consumption and semen quality is limited. Therefore, this study was conducted to investigate the association between animal flesh foods consumption with semen quality. Methods In this cross-sectional study, 400 newly-identified (< 6 months) infertile men, as diagnosed by an andrologist, were recruited into the study. Dietary intake was assessed by using a semiquantitative Food Frequency Questionnaire. The total meat consumption was defined as the sum of red meat, poultry, fresh fish, canned fish, processed meats, and organ meats in the diet. A linear mixed model was used to assess the relationship between meat consumption and semen quality indicators of participants. Results Consumption of canned fish was inversely related to sperm immotility. Compared with the men in the lowest quartile of canned fish intake, those in the highest quartile had a lower sperm immotility [lowest quartile: 52.5%; (95% CI: 47–57) vs 47.4%; (95% CI: 43–51) P-trend = 0.026]. Similarly, a trend toward an inverse significant association between fresh fish intake and sperm immotility was observed (P-trend = 0.074). In contrast, fresh and canned fish intake was unrelated to other outcomes of sperm quality (P-trend > 0.05). No association was found between consumption of processed red meat, red meat, poultry, and organ meat, and semen quality indicators (P-trend > 0.05). Conclusions We found that consumption of canned fish is associated with a lower percentage of immotile sperm, whilst a high consumption of fresh fish increased the percentage of immotile sperm in Iranian infertile men. Further studies are recommended in this regard.

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