Serum albumin levels are associated with sex steroids hormones and sperm concentration impairment in primary infertile men – results of a cross-sectional study

Abstract Background The aim of this study was to provide information on the semen quality pattern of infertile men and age thresholds for semen parameters in China. Methods This was a retrospective cross-sectional study investigating 71,623 infertile men from the Reproductive and Genetic Hospital of CITIC Xiangya in Hunan, China, from 2011 to 2017. The Kruskal-Wallis test, Mann-Kendall test, linear regression model and joinpoint regression were used. Results Although erratic changes were observed in the median semen parameters (sperm concentration 40.1–52.1 × 106/ml, total sperm count 117.8–153.1 × 106, sperm progressive motility 33.4–38.1%) during the 7 years of observation, no significant decrease in semen quality was found, and 47.88% of infertile men showed normal semen parameters according to the World Health Organization (WHO) criteria. According to the joinpoint regression analysis, sperm progressive motility appeared to decrease earlier than the sperm concentration and total sperm count (at 28, 58, and 42 years of age, respectively). Conclusions There is no evidence of a deterioration in semen quality among infertile men in Hunan, China. Semen parameters decreased with increasing age, with turning points noted at different ages. Semen parameters are not absolute evidence for the assessment of male fertility potential. Therefore, we believe that, among semen parameters, the sperm concentration is the best predictor of fertility for ART, followed by motility. Decreased sperm motility may affect natural pregnancy, but it is not necessary for successful IVF.

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Low serum albumin, aspartate aminotransferase, and body mass are risk factors for frailty in elderly people with diabetes: possible mechanistic role of dehydroepiandrosterone sulfate – a cross-sectional study

10.21203/rs.2.22681/v1 ◽

2020 ◽

Author(s):

Toshihiko Yanase ◽

Ikumi Yanagita ◽

Yuya Fujihara ◽

Chikayo Iwaya ◽

Yuichi Kitajima ◽

...

Keyword(s):

Risk Factors ◽

Regression Analysis ◽

Serum Albumin ◽

Body Mass ◽

Aspartate Aminotransferase ◽

Dehydroepiandrosterone Sulfate ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Independent Risk Factors

Abstract Background: Relatively low dehydroepiandrosterone sulfate (DHEA-S) and high cortisol/DHEA ratio have been suggested to be associated with frailty, evaluated using a physical scale. However, the significance of these two hormones for frailty in elderly patients with type 2 diabetes mellitus (T2DM) has not been assessed using a wider range of measures of frailty, including physical, mental, and social indices. Methods: We performed a cross-sectional study to investigate the significance of these two hormones for frailty in elderly T2DM patients (n=148; ≥65 years), using a broad assessment, the clinical frailty scale, and to reevaluate the risk factors for frailty in elderly T2DM patients. We compared parameters between the non-frail and frail groups using the unpaired t and Mann-Whitney U tests. The Jonckheere-Therpstra test was used to identify relationships with the severity of frailty and risk factors were identified using binary regression analysis. Results: Simple regression analysis identified a number of significant risk factors for frailty, including DHEAS <70 µg/dL and cortisol/DHEA-S ratio ≥0.2. Multiple regression analysis showed that low albumin (<4.0 g/dl) (odds ratio [OR]=5.79, p <0.001), low aspartate aminotransferase (AST) activity (<25 IU/L) (OR=4.34, p =0.009), and low body mass (BM) (<53 kg) (OR=3.85, p =0.012) were independent risk factors for frailty. A significant decrease in DHEA-S and a significant increase in the cortisol/DHEA-S ratio occurred alongside increases in the severity of frailty. DHEA-S concentration positively correlated with both serum albumin and BM. Conclusions: Hypoalbuminemia, low AST, and low BM are independent risk factors for frailty in elderly T2DM patients, strongly implying relative malnutrition in these frail patients. DHEA-S may be important for the maintenance of liver function and BM. A decrease in DHEA-S and an increase in the cortisol/DHEAS ratio may be involved in the mechanism of the effect of malnutrition in elderly T2DM patients.

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The impact of semen infections over sperm parameters in primary infertile men - results from a real life, cross-sectional study

Fertility and Sterility ◽

10.1016/j.fertnstert.2018.07.840 ◽

2018 ◽

Vol 110 (4) ◽

pp. e299

Author(s):

F. Pederzoli ◽

E. Ventimiglia ◽

P. Capogrosso ◽

L. Boeri ◽

W. Cazzaniga ◽

...

Keyword(s):

Real Life ◽

Cross Sectional Study ◽

Sperm Parameters ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Men ◽

The Impact

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Fibrinogen status in relapse and remission of childhood nephrotic syndrome

Paediatrica Indonesiana ◽

10.14238/pi46.4.2006.149-53 ◽

2016 ◽

Vol 46 (4) ◽

pp. 149

Author(s):

Veronica Lily Limantara ◽

Ida Bagus Mudita ◽

I Ketut Suarta

Keyword(s):

Nephrotic Syndrome ◽

Serum Albumin ◽

Cross Sectional Study ◽

Fibrinogen Concentration ◽

Strongly Correlated ◽

Sectional Study ◽

Laboratory Findings ◽

Cross Sectional ◽

Remission Status ◽

The Mean

Objective To evaluate fibrinogen concentration of relapsing neph-rotic syndrome (NS) in children, and to investigate relationshipbetween fibrinogen with albumin and cholesterol.Methods A cross-sectional study among NS patients admitted topediatric outpatient clinic and pediatric ward at Sanglah Hospital,Denpasar, from November 1, 2003 to January 31, 2004. All pa-tients were evaluated for clinical and laboratory findings of relapseand remission, including edema, proteinuria, serum albumin, totalcholesterol, as well as total platelet count and fibrinogen concen-tration to evaluate coagulation parameters in nephrotic patients.Results There were 36 patients with the mean age of 7.4 (SD 2.3)years included in this study. Mean fibrinogen concentration in re-lapse state was 671.8 (SD 102.7) mg/dl, while in remission statewas 255.2 (SD 50.5 mg/dl); the mean difference was 416.6 mg/dl(95% CI 362.9;470.4; P<0.001). Fibrinogen was inversely andstrongly correlated with serum albumin concentrations (r=-0.91;P<0.001). Fibrinogen was positively and strongly correlated to to-tal cholesterol (r=0.80; P<0.001). Using multiple regression analy-sis, it was shown that only relapse/remission status was signifi-cantly associated with fibrinogen concentration (P<0.001).Conclusion Fibrinogen status is significantly correlated with re-lapse and remission status of NS in childhood patients.

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Association between varicocele grade and semen analysis parameter

Medical Journal of Indonesia ◽

10.13181/mji.v26i4.1623 ◽

2018 ◽

Vol 26 (4) ◽

pp. 270-6 ◽

Cited By ~ 2

Author(s):

Ira Ariyati ◽

Rahmad Mulyadi ◽

Ponco Birowo ◽

Budi Wiweko ◽

Joedo Prihartono

Keyword(s):

Sperm Morphology ◽

Semen Analysis ◽

Sperm Concentration ◽

Secondary Data ◽

Cross Sectional Study ◽

Sectional Study ◽

Maximum Condition ◽

Cross Sectional ◽

Doppler Examination ◽

Pampiniform Plexus

Background: Varicocele is a condition characterized by elongation, dilatation and tortuousity of spermatic vein in pampiniform plexus. Approximately 50% of infertility cases among men are caused by varicocele. The varicocele may affect the components of sperm. This study aimed to determine the association between varicocele grade based on ultrasound Doppler examination and sperm concentration, sperm motility, and sperm morphology based on semen analysis examination.Methods: This was a descriptive, cross-sectional study which used secondary data from 85 patients that visited Department of Urology, Cipto Mangunkusumo Hospital, then underwent ultrasonography examination at Department of Radiology, Cipto Mangunkusumo Hospital and semen analysis examination at Department of Obstetrics and Gynecology, Cipto Mangunkusumo General Hospital.Results: Varicocele grade was significantly associated with sperm morphology, concentration and motility (all p<0.05). Significant association was found between maximum condition and semen analysis component.Conclusion: Varicocele grade may affect semen analysis component.

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Dietary Antioxidant Intake in Relation to Semen Quality Parameters in Infertile Men: a Cross-Sectional Study

Clinical Nutrition Research ◽

10.7762/cnr.2019.8.3.229 ◽

2019 ◽

Vol 8 (3) ◽

pp. 229

Author(s):

Mehran Rahimlou ◽

Sara Sohaei ◽

Mohammadhossein Nasr-Esfahani ◽

Mehran Nouri

Keyword(s):

Semen Quality ◽

Cross Sectional Study ◽

Quality Parameters ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Men ◽

Dietary Antioxidant ◽

Antioxidant Intake

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The association between animal flesh foods consumption and semen parameters among infertile Iranian men: a cross-sectional study

Nutrition Journal ◽

10.1186/s12937-020-00633-w ◽

2020 ◽

Vol 19 (1) ◽

Author(s):

Reza Ghiasvand ◽

Laleh Dehghan Marvast ◽

Seyyed Payam Shariatpanahi ◽

Makan Pourmasoumi ◽

Cain C. T. Clark ◽

...

Keyword(s):

Quality Indicators ◽

Semen Quality ◽

Cross Sectional Study ◽

Red Meat ◽

Fish Intake ◽

Sectional Study ◽

Cross Sectional ◽

Fresh Fish ◽

Infertile Men ◽

Canned Fish

Abstract Background Previous studies have demonstrated the association between dietary patterns and semen quality indicators, but research on the possible association between animal flesh foods consumption and semen quality is limited. Therefore, this study was conducted to investigate the association between animal flesh foods consumption with semen quality. Methods In this cross-sectional study, 400 newly-identified (< 6 months) infertile men, as diagnosed by an andrologist, were recruited into the study. Dietary intake was assessed by using a semiquantitative Food Frequency Questionnaire. The total meat consumption was defined as the sum of red meat, poultry, fresh fish, canned fish, processed meats, and organ meats in the diet. A linear mixed model was used to assess the relationship between meat consumption and semen quality indicators of participants. Results Consumption of canned fish was inversely related to sperm immotility. Compared with the men in the lowest quartile of canned fish intake, those in the highest quartile had a lower sperm immotility [lowest quartile: 52.5%; (95% CI: 47–57) vs 47.4%; (95% CI: 43–51) P-trend = 0.026]. Similarly, a trend toward an inverse significant association between fresh fish intake and sperm immotility was observed (P-trend = 0.074). In contrast, fresh and canned fish intake was unrelated to other outcomes of sperm quality (P-trend > 0.05). No association was found between consumption of processed red meat, red meat, poultry, and organ meat, and semen quality indicators (P-trend > 0.05). Conclusions We found that consumption of canned fish is associated with a lower percentage of immotile sperm, whilst a high consumption of fresh fish increased the percentage of immotile sperm in Iranian infertile men. Further studies are recommended in this regard.

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