NASAL NEUROBLASTOMA: REVIEW AND CASE REPORT

Abstract Sinonasal neuroblastoma is a rare malignant tumor with a wide variability of clinical manifestations, which may cause diagnostic difficulty and have hindered the progress in understanding the clinical course and improving outcomes of treatment. Patients often present with nasal obstruction, rhinorrhea, recurrent epistaxis, hyposmia, or anosmia. Treatment options consist of surgical resection and before or followed radiation and chemotherapy. We present a case report and short literature review about diagnostic, clinical and histological classification and treatment of this tumor. Keywords: neuroblastoma, nasal cavity, diagnostic, classification, treatment.

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Keratosis Lichenoides Chronica – a Case Report and Literature Review

Serbian Journal of Dermatology and Venerology ◽

10.2478/sjdv-2014-0011 ◽

2014 ◽

Vol 6 (3) ◽

pp. 120-137

Author(s):

Mirjana Paravina ◽

Predrag Cvetanović ◽

Miloš Kostov ◽

Slađana Živković ◽

Ivana Dimovski ◽

...

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Literature Review ◽

Rare Disease ◽

Clinical Picture ◽

Treatment Options ◽

Clinical Manifestations ◽

Poor Response ◽

Unknown Etiology ◽

Distinct Entity

Abstract Keratosis lichenoides chronica represents a distinct entity, a rare disease of unknown etiology and pathogenesis, with clinical manifestations which, although typical, require extensive differential diagnosis. The course of the disease is chronic, progressive, and it is resistant to various treatment options, so despite variations in the clinical picture it is really easier to diagnose than to treat. This is a case report of a male patient in whom the diagnosis of keratosis lichenoides chronica was based on typical clinical picture, repeated biopsies and histopathological findings, course of the disease and poor response to any therapy.

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Extracalvarial Composite Infantile Myofibromatosis: Case Report and Literature Review

European Journal of Pediatric Surgery Reports ◽

10.1055/s-0036-1580704 ◽

2016 ◽

Vol 04 (01) ◽

pp. 022-025 ◽

Cited By ~ 1

Author(s):

Alexander Ivanov ◽

Tibor Valyi-Nagy ◽

Dimitrios Nikas

Keyword(s):

Case Report ◽

Genetic Testing ◽

Soft Tissue ◽

Literature Review ◽

Clinical Course ◽

Treatment Options ◽

Soft Tissue Tumors ◽

Infantile Myofibromatosis ◽

Histopathological Features

Infantile soft tissue tumors of the head are very rare and the majority of them are myofibromas. The authors present the case of a 1-day-old boy with a scalp tumor with several distinct histopathological features including myofibroma, hemangiopericytoma, and fibrosarcoma consistent with the diagnosis of composite infantile myofibromatosis. Genetic testing was negative for trisomy 17, translocation (12; 15), FUS, and ETV6 translocations. Despite the ominous histopathological features, the clinical course was benign. The authors review here available literature concerning current concepts of making the diagnosis of composite infantile myofibromatosis and discuss treatment options.

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Acute Kidney Injury Secondary to Rhabdomyolysis and COVID-19: A Case Report and Literature Review

Case Reports in Nephrology ◽

10.1155/2021/5528461 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Vishaka K. Chetram ◽

Akram I. Ahmad ◽

Saira Farid ◽

Tanuj Sood

Keyword(s):

Acute Kidney Injury ◽

Case Report ◽

Literature Review ◽

Viral Infection ◽

Clinical Course ◽

Clinical Manifestations ◽

Kidney Injury ◽

Laboratory Findings ◽

Global Spread ◽

Uncommon Complication

The viral infection causing COVID-19 most notably affects the respiratory system but can result in extrapulmonary clinical manifestations as well. Rhabdomyolysis-associated acute kidney injury (AKI) in the setting of COVID-19 is an uncommon complication of the infection. There is significant interest in this viral infection given its global spread, ease of transmission, and varied clinical manifestations and outcomes. This case report and literature review describes the symptoms, laboratory findings, and clinical course of a patient who developed AKI secondary to rhabdomyolysis and COVID-19, which will help clinicians recognize and treat this condition.

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Epidermoid brain cysts: a case report and a literature review

Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery) ◽

10.33920/med-01-2105-04 ◽

2021 ◽

pp. 358-371

Author(s):

Maksim Vladimirovich Shpagin ◽

Anton Viktorovich Yarikov ◽

Denis Nikolaevich Nikitin ◽

Igor Anatolievich Lobanov ◽

Ivan Aleksandrovich Laganin ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Cerebellopontine Angle ◽

Clinical Manifestations ◽

Complex Treatment ◽

Brain Pathology ◽

Epidermoid Cysts ◽

Histological Picture ◽

Clinical Observations ◽

Brain Cysts

The article is devoted to rare brain pathology, i.e. epidermoid cysts. The histological picture of the tumor is described; the classification is given. On the basis of our own clinical observations and a literature review, the features of the clinical manifestations of cholesteatoma of the cerebellopontine angle, modern approaches to the diagnosis and tactics of complex treatment are presented.

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Ornidazole-Induced Recurrent Encephalopathy in a Chinese Man: A Rare Case Report and Literature Review

Frontiers in Neurology ◽

10.3389/fneur.2021.706094 ◽

2021 ◽

Vol 12 ◽

Author(s):

Rong Tang ◽

Jia Liang ◽

Yuanfang Li ◽

Tingting Wu ◽

Yuhao Zhang ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Corpus Callosum ◽

Cerebellar Ataxia ◽

Drug Withdrawal ◽

Clinical Manifestations ◽

Good Prognosis ◽

Drug Discontinuation ◽

Imaging Features ◽

Mental Symptoms

Ornidazole-induced encephalopathy (OIE) is seldom seen in the clinic. In this study, we report a new case of a patient who had taken 1,000 mg ornidazole daily for nearly 4 years because of suspected diarrhea and proctitis and presented with subacute symptoms such as unsteady gait, slurred speech, and psychiatric disorder. These symptoms were significantly relieved 3 days after the patient stopped taking ornidazole. When he took this medicine again, however, similar symptoms occurred 4 months later, which were again reduced after 4 days of drug discontinuation. After the second onset, abnormal signals were identified around the aqueduct of the midbrain, around the fourth ventricle, and in the dentate nuclei of the cerebellum bilaterally. After 9 days of drug discontinuation, lesions disappeared in the magnetic resonance imaging (MRI) results. According to the clinical manifestations, imaging features, and the reduced symptoms after drug withdrawal, we clinically diagnosed the patient with OIE. This paper also reviews the literature on OIE. Only five cases (including our case) have been reported, all of whom presented with cerebellar ataxia and dysarthria and three with additional mental symptoms such as agitation and irritability. All five patients had abnormal lesions in the dentate nucleus of the cerebellum bilaterally, among whom four also had lesions in the corpus callosum and three around the periaqueduct of the midbrain. After withdrawal of ornidazole, the symptoms in all patients vanished or were alleviated, and three of them showed reduced or disappeared lesions in a head MRI reexamination. Overall, OIE has rarely been reported. Our case report and literature review show that the lesions in the cerebellum, corpus callosum, and brainstem can be reversed. The main manifestations of the lesions—cerebellar ataxia, dysarthria, and mental symptoms—quickly weaken or disappear after drug withdrawal, with good prognosis. Nevertheless, clear pathogenesis has yet to be further investigated.

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Dural Ectasia in Neurofibromatosis 1: Case Series, Management, and Review

Neurosurgery ◽

10.1093/neuros/nyz244 ◽

2019 ◽

Vol 86 (5) ◽

pp. 646-655

Author(s):

Sean P Polster ◽

Mark C Dougherty ◽

Hussein A Zeineddine ◽

Seán B Lyne ◽

Heather L Smith ◽

...

Keyword(s):

Natural History ◽

Clinical Course ◽

Treatment Options ◽

Plexiform Neurofibroma ◽

Clinical Manifestations ◽

Case Series ◽

Neurofibromatosis 1 ◽

Dural Ectasia ◽

Asymptomatic Patients ◽

Nonsurgical Patients

Abstract BACKGROUND The natural history and management of dural ectasia in Neurofibromatosis 1 (NF1) is still largely unknown. Dural ectasias are one of the common clinical manifestations of NF1; however, the treatment options for dural ectasias remain unstudied. OBJECTIVE To investigate the natural history, diagnosis, management, and outcome of the largest case series of patients with NF1-associated dural ectasia to date. METHODS Records from our NF1 clinic were reviewed to identify NF1 patients with computed tomography or magnetic resonance imaging evidence of dural ectasia(s) to determine their clinical course. Demographics, symptoms, radiographic and histopathologic findings, treatment, and clinical course were assessed. RESULTS Thirty-four of 37 patients were managed without surgery. Of the 18 initially asymptomatic patients, 5 (27.8%) progressed to symptoms attributable to a dural ectasia (onset of 2.7% per patient-year). Three patients required surgical intervention because of extraspinal mass effect. All 3 initially improved but had symptom recurrence within 2 yr. Reoperation involved shunt placement for cerebrospinal fluid (CSF) diversion. On imaging review, 26 (76.5%) of the nonsurgical patients harbored an associated nearby plexiform neurofibroma. Pathology of one surgical case revealed dural infiltration by diffuse neurofibroma. CONCLUSION Using the largest NF1-associated dural ectasia group to date, we report the first symptom-onset rate for nonsurgical patients. In the few cases requiring surgery for decompression, primary resection, and patching of ectasias failed, subsequently requiring CSF shunting. We demonstrate imaging evidence of nearby plexiform neurofibroma in a majority of cases, which, when combined with histopathology, provides a novel explanation for the formation of dural ectasias.

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Arthritis in children with LRBA deficiency – case report and literature review

Pediatric Rheumatology ◽

10.1186/s12969-019-0388-4 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 1

Author(s):

Rotem Semo Oz ◽

Melissa S. Tesher

Keyword(s):

Case Report ◽

Literature Review ◽

Rheumatic Disease ◽

Case Reports ◽

Clinical Manifestations ◽

Immune Dysregulation ◽

Joint Involvement ◽

Female Ratio ◽

Minimal Data ◽

Lrba Deficiency

Abstract Background Lipopolysaccharide (LPS)-responsive and beige like anchor (LRBA) deficiency is categorized as a subtype of common variable immune deficiency (CVID). A growing number of case reports and cohorts reveal a broad spectrum of clinical manifestations and variable phenotype expression, including immune dysregulation, enteropathy and recurrent infections. The association between rheumatic disease and CVID generally has been well established, arthritis has been less frequently reported and minimal data regarding its clinical features and characteristic in LRBA deficiency has been published. This case report and literature review evaluates the characteristics and features of arthritis in LRBA deficiency patients. Case presentation and review results Herein, we describe a unique case of LRBA deficiency first presented with poly articular arthritis. Alongside the report, a literature review focusing on LRBA deficiency, rheumatic disease and arthritis has been conducted. We reviewed 43 publications. Among these, 7 patients were identified with arthritis. Age of first presentation was six weeks to 3 years. Male to female ratio was 4/3. Two patients were diagnosed with polyarticular Juvenile idiopathic arthritis (JIA) and three with oligoarticular JIA. Each patient was found to have different genomic mutation. The treatment was diverse and included corticosteroids, cyclosporine, methotrexate, adalidumab and abatacept. Conclusion Joint involvement is variable in LRBA deficiency, hence it should always be kept in mind as a differential diagnosis for a patient with combination of juvenile arthritis and clinically atypical immune dysregulation and / or immunodeficiency.

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Successful treatment of thrombocytopenia with daratumumab after allogeneic transplant: a case report and literature review

Blood Advances ◽

10.1182/bloodadvances.2019001215 ◽

2020 ◽

Vol 4 (5) ◽

pp. 815-818 ◽

Cited By ~ 3

Author(s):

Yazan Migdady ◽

Asiri Ediriwickrema ◽

Ryan Patrick Jackson ◽

Wendy Kadi ◽

Ridhi Gupta ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Successful Treatment ◽

Standard Treatment ◽

Treatment Options ◽

Allogeneic Transplant ◽

Novel Treatment ◽

Short Course ◽

Key Points ◽

Lymphocyte Populations

Key Points A source of treatment refractoriness in immune cytopenias appears to be residual CD138/38-positive lymphocyte populations. A short course of daratumumab is a novel treatment of refractory thrombocytopenia after failure of standard treatment options.

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Primary Adrenal Leiomyosarcoma: A Case Report and Literature Review

Clinical medicine Oncology ◽

10.4137/cmo.s627 ◽

2008 ◽

Vol 2 ◽

pp. CMO.S627 ◽

Cited By ~ 2

Author(s):

M Mencoboni ◽

M Bergaglio ◽

M Truini ◽

M Varaldo

Keyword(s):

Case Report ◽

Literature Review ◽

Adrenal Mass ◽

Clinical Course ◽

Therapeutic Strategies ◽

Anatomic Site ◽

Histological Features ◽

Mesenchymal Neoplasm ◽

Diagnostic Approaches ◽

Final Histological Diagnosis

The case presented here illustrates a 75 year old female patient who underwent surgical resection of a right adrenal mass of uncertain nature. The final histological diagnosis was consistent with leiomyosarcoma arising from the adrenal anatomic site. Primary leiomyosarcoma of the adrenal gland is a very rare malignant mesenchymal neoplasm: to our knowledge, this is only the twelfth case reported in literature. We describe the clinical course and a brief review of clinical and histological features, biologic behaviour, diagnostic approaches and therapeutic strategies.

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