scholarly journals Preparation and Characterization of Curcumin Nanoemulsion in Olive Oil-Tween 80 System using Wet Ball Milling Method

2021 ◽  
Vol 1 (1) ◽  
pp. 16
Author(s):  
Zubaidah Ningsih ◽  
Maria Lucia A.D Lestari ◽  
Salza Aprilia Rahma Maharin
Keyword(s):  
Particle Size ◽  
Olive Oil ◽  
Ball Milling ◽  
Tween 80 ◽  
Dispersing Agent ◽  
Milling Method ◽  
Dynamic Light Scattering Technique ◽  
Nano Emulsion ◽  
Agent Particle

Nanoemulsion has been developed as a drug delivery system which increases bioavailability and effectiveness of curcumin. Many methods and formulations have been applied in order to fabricate the most efficient nanoemulsion system to deliver curcumin. Wet ball milling is a simple technique to grind solids like powder to produce nano emulsion. On the other hand, a combination of olive oil and curcumin in Mediterranian Diet shows a promising anticancer activity. This research aims to elaborate the preparation and characterization of curcumin nanoemulsion in olive oil-Tween 80 system with wet ball milling method. It is expected that the procedure yields a combination of curcumin and olive oil in nanoemulsion system with simple preparation. This research uses curcumin as active compound, olive oil as solvent for curcumin, Tween 80 as stabilizer, and water as dispersing agent. Particle size and polydispersity index are determined using Dynamic Light Scattering technique. The results show that the best milling time is 8 hours to produce nanoemulsion that has diameter of 303 nm and polidispersity index of 0.29. Nanoemulsion system is stable for 60 days storage at 4 oC and 25 oC. The maximum curcumin mass that can be loaded in the system while maintaining particle size in nanoemulsion range is 300 mg.

Effects of Tween 80 dispersant on LiFePO4/C cathode material prepared by sonochemical high-temperature ball milling method

Ionics ◽  
2019 ◽  
Vol 25 (11) ◽  
pp. 5565-5573
Author(s):  
Qing Zhao ◽  
Xuetian Li ◽  
Zhongbao Shao ◽  
Chengjun Liu ◽  
Ron Zevenhoven
Keyword(s):  
High Temperature ◽  
Cathode Material ◽  
Ball Milling ◽  
Tween 80 ◽  
Milling Method

scholarly journals Utilization and Characterization of Oyster Shell as Chitosan and Nanochitosan

2018 ◽  
Vol 21 (4) ◽  
pp. 224-231
Author(s):  
Lia Handayani ◽  
Faisal Syahputra ◽  
Yayuk Astuti
Keyword(s):  
Particle Size ◽  
Morphological Analysis ◽  
Oyster Shell ◽  
Tween 80 ◽  
Raw Material ◽  
Initial Weight ◽  
Deacetylation Degree ◽  
Chitosan Particle

Oyster is one of bivalve groups widely consumed by human, thus, it results in producing huge waste shells affecting the environment. One way to increase the value of oyster shells is to process them into chitosan. This study aims to isolate chitin then synthesize it into chitosan and convert chitosan into nano-sized chitosan and analyze the characteristics. The steps to produce chitosan from waste shells included demineralization using HCl 1 N and deproteinization using NaOH 3%. The next step was to convert chitin into chitosan through a deacetylation process using NaOH 50%. After chitosan was formed, it was continued to convert chitosan into nano chitosan particles using ion gelation method with the addition of surfactant (tween 80) and crosslinker (TPP 0.1% and 0.5%). The results showed that yield of transformation chitin into chitosan was 61.1%. Meanwhile, the yield calculated from initial weight of raw material was 18.33% with deacetylation degree value equal to 89.14%. Based on morphological analysis using SEM, the size of chitosan particles was not distributed homogeneously that was in the range of 892 nm-1.54 μm, while the nano chitosan particle size obtained was uniformly formed in the range of 679 nm-910 nm.

scholarly journals Preparation of Curcumin Nanoemulsion in Soybean Oil – Tween 80 System by Wet Ball Milling Method

2020 ◽  
Vol 833 ◽  
pp. 012044
Author(s):  
Shobbu Ibabas Sholihat ◽  
Ellya Indahyanti ◽  
Maria Lucia A.D Lestari ◽  
Zubaidah Ningsih
Keyword(s):  
Soybean Oil ◽  
Ball Milling ◽  
Tween 80 ◽  
Milling Method

scholarly journals Formulasi dan Stabilitas Nanostructured Lipid Carrier dari Campuran Fraksi Stearin dan Olein Minyak Kelapa Sawit

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Miftakhur Rohmah ◽  
Sri Raharjo ◽  
Chusnul Hidayat ◽  
Ronny Martien
Keyword(s):  
Particle Size ◽  
Bioactive Compounds ◽  
Delivery System ◽  
Ph Value ◽  
Palm Stearin ◽  
Tween 80 ◽  
Nanostructured Lipid Carrier ◽  
High Shear ◽  
Third Stage

Nanostructured Lipid Carriers (NLC) adalah sistem pembawa berbasis lipida yang menggunakan kombinasi matriks berupa lipid padat dan cair yang distabilkan dengan penambahan surfaktan. NLC ini dikembangkan untuk memfasilitasi dispersi senyawa bioaktif hidrofobik dalam sistem hidrofilik.  Penelitian ini bertujuan untuk mendapatkan formulasi yang tepat untuk menghasilkan dan mengevaluasi stabilitas NLC yang menggunakan fraksi stearin dan fraksi olein minyak kelapa sawit sebagai lipid padat dan cair serta penambahan surfaktan Tween 80. Tahap pertama penelitian ini adalah membuat formula NLC dengan menggunakan metode High Shear Homogenisasi dan Ultrasonication dengan rasio lipid padat:lipid cair adalah 5:5 sd. 9:1% b/b, rasio lipid:surfaktan sebesar 1:3 sd. 1:5% b/b, dan rasio lipid + surfaktan/air adalah 65, 70, 80 dan 85% b/b. Tahap kedua adalah pengujian stabilitas NLC terhadap sentrifugasi, pemanasan pendinginan, dan penyimpanan pada suhu ruang selama 30 hari. Tahap ketiga yaitu karakterisasi NLC stabil meliputi nilai pH, vikositas, ukuran partikel, indeks polidispersi (PDI), potensial zeta (ZP) dan morfologi NLC. Hasil penelitian menunjukkan NLC stabil pada rasio lipid padat:lipid cair sebesar 5:5 sd. 9:1, rasio lipid:surfaktan adalah 1:4 sd.1:5, rasio lipid + surfaktan/air sebesar 65, 70, 75 dan 80%, pH pada kisaran 6,28±0,15 sd. 6,44±0,11, viskositas sebesar 18,17±0,29 sd. 26,83±1,61 cP, ukuran partikel sebesar 164,3±6,6 s.d. 340±2,0 nm, PDI sebesar 0,20±0,01 sd. 0,53±0,01, ZP sebesar (-21,25±0,01) sd. (-33,70±0,44) mV, dan memiliki morfologi bulat. Kesimpulannya, informasi tentang formulasi dan stabilitas NLC sebagai sistem pembawa senyawa bioaktif hidrophobik dapat digambarkan dengan baik. Formulation and Stability of Nanostructured Lipid Carrier Prepared from a Mixture of Palm Stearin and Palm OleinAbstractNanostructured Lipid Carriers (NLC) is a lipid-based delivery system using a matrix of solid and liquid lipids stabilized with surfactants, developed to facilitate the dispersion of hydrophobic bioactive compounds in hydrophilic systems. This study aimed to evaluate the formulation and stability of the NLC delivery system produced using palm stearin and palm olein as solid and liquid lipids as well as Tween 80 surfactant. As initial research, NLC formulations was done using the High Shear Homogenization and Ultrasonication using the ratio of solid:liquid lipids of 5:5 to 9:1% w/w, ratio lipid:surfactant as much as 1:3 to 1:5% w/w, and lipid+surfactant/water as much as 65, 70, 80 and 85% w/w. The second stage was testing the NLC stability against centrifugation, cooling, heating, and storage at room temperature for up to 30 days. The third stage was characterization of stable NLC i.e. pH, viscosity, particle size, polydispersion index (PDI), potential zeta (ZP), and NLC morphology. The results showed stable NLC at the ratio of solid:liquid lipids as much as 5:5 to 9:1, ratio of lipid:surfactant was 1:4 to 1:5, ratio of lipid+surfactant/water was 65, 70, 75 and 80%, pH value was 6.28±0.15 to 6.44±0.11, viscosity 18.17±0.29 to 26.83±1.61 cP, particle size was 164.3±6.6 to 340±2.0 nm, PDI was 0.20±0.01 to 0.53±0.01, ZP (-21.25±0.01) to (-33.70±0.44) mV, and had spherical morphology. As conclusion, the design of NLC as a delivery system for bioactive compounds was presented succesfully.

scholarly journals Characterization of kaolin dispersion using acoustic and electroacoustic spectroscopy

2008 ◽  
Vol 44 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Z. Dohnalová ◽  
L. Svoboda ◽  
P. Sulcová
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Divalent Cations ◽  
Dispersing Agent ◽  
Time Period ◽  
Ultrasonic Techniques

The objective of this work is the investigation of the kaolin dispersion by the ultrasonic techniques. In contact with aqueous solution clay minerals show cation - exchange properties and certain degree of dissolution or rather selective leaching of components. The work is divided into two main parts - determination of zeta potential and particle size distribution. The first part is focused on measuring of zeta potential. Effects of concentration of solid, different kind of electrolytes (0.01 M KCl, 0.01 M MgCl2 and 0.01 M CaCl2), pH and temperature of the dispersions are investigated. The isoelectric points (IEP) of kaolin suspension are about pH 4-5. Electrolytes containing monovalent cations such as K+ become zeta potential more negative compared to the values obtained with water. Such behavior is explained by the exchange of K+ ions with H+ ions in the system. When the electrolyte is formed by divalent cations such as Mg2+ or Ca2+, the values of zeta potential become less negative than zeta potential of kaolin in water. The second part is focused on the determination of particle size distribution with respect to dispersing conditions, such as the optimal dispersing agent (Na2SiO3, (NaPO3)6, Na4P2O7 or Busperse), time and power of ultrasonication and also the tracking of dispersion stability that is expressed by the measuring of particle size distribution during certain time period.

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