scholarly journals Characteristics of lumbar disc degeneration and risk factors for collapsed lumbar disc in Korean farmers and fishers

2021 ◽  
Vol 33 ◽  
Author(s):  
Chaeyoung Hong ◽  
Chul Gab Lee ◽  
Hansoo Song
Keyword(s):  
Risk Factors ◽  
Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration

scholarly journals Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study

2011 ◽  
Vol 70 (10) ◽  
pp. 1740-1745 ◽  
Author(s):  
Gregory Livshits ◽  
Maria Popham ◽  
Ida Malkin ◽  
Philip N Sambrook ◽  
Alex J MacGregor ◽  
...  
Keyword(s):  
Risk Factors ◽  
Low Back Pain ◽  
Back Pain ◽  
Disc Degeneration ◽  
Genetic Factors ◽  
Lumbar Disc ◽  
Low Back ◽  
Lumbar Disc Degeneration ◽  
Sibling Pairs ◽  
Validated Questionnaire

ObjectiveLow back pain (LBP) is a common musculoskeletal disorder, but it is still unclear which individuals develop it. The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in a female sample of the general population.Material and MethodsA cross-sectional study was conducted among 2256 women (371 and 698 monozygotic and dizygotic twin pairs and 29 sibling pairs and 60 singletons) with a mean age of 50 years (18–84). A self-reported validated questionnaire was used to collect back pain data. Risk factors including body weight, smoking, occupation, physical exercise and MRI assessed LDD were measured. Data analysis included logistic regression and variance decomposition.ResultsThe major factors associated with LBP included genetic background, with OR approximately 6 if the monozygotic co-twin had LBP, or 2.2 if she was a dizygotic co-twin. In addition, LDD and overweight were highly significantly (p<0.001) associated with non-specific LBP. The single most important risk factor was the amount of LDD. After adjustment for other risk factors, the individuals who exhibited advanced LDD (90% vs 10%) had 3.2 higher odds of manifesting LBP. The data also showed a significant (p<0.001) genetic correlation between the LBP and LDD measurements, suggesting that approximately 11–13% of the genetic effects are shared by LDD and LBP.ConclusionsThe main risk factors for reported episodes of severe and disabling LBP in UK women include the degree of LDD as assessed by MRI, being overweight and genetic heritability.

Risk Factors for Lumbar Disc Degeneration in High School American Football Players

2013 ◽  
Vol 41 (9) ◽  
pp. 2059-2064 ◽  
Author(s):  
Masaki Nagashima ◽  
Hitoshi Abe ◽  
Kenji Amaya ◽  
Hideo Matsumoto ◽  
Hisashi Yanaihara ◽  
...  
Keyword(s):  
Risk Factors ◽  
High School ◽  
Disc Degeneration ◽  
Lumbar Disc ◽  
American Football ◽  
Football Players ◽  
Lumbar Disc Degeneration

scholarly journals Analysis of Risk Factors for Spinal Pain: A Case Control Study of New Graduate Aviators Based on Imaging and Questionnaire Results.

2020 ◽  
Author(s):  
Fang Xie ◽  
Yachao Ma ◽  
Zhipeng Tu ◽  
Peipei Huang ◽  
Zhe Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disc Degeneration ◽  
Lumbar Disc ◽  
Multivariate Logistic Regression Analysis ◽  
Spinal Pain ◽  
Degenerative Changes ◽  
Cervical Disc ◽  
Lumbar Disc Degeneration ◽  
Disc Protrusion ◽  
New Graduate

Abstract Background: Disc degenerative diseases are common in occupational aviators exposed to long flight time and vibration during flight. The incidence of pathological and degenerative changes of spine in experienced pilots are widely studied and reported. However, few literatures focused on new graduate aviators. In this study we intended to describe imaging features of spine in new graduate aviators from flight academy and analyzed the risk factors for spinal pain.Methods: This is a retrospective study of 178 new graduate aviators. All received full-length lateral X-ray of spine and 1.5T magnetic resonance imaging (MRI) of cervical and lumbar spine. Sagittal alignments were measured through X-ray imaging. The degenerative grade of disc was defined according to Miyazaki and Pfirrmann grading classifications. The prevalence of degenerative disc diseases was reported under disc nomenclatures. The incidence of spinal pain during the last 12 months of flight training was acquired from questionnaires. Multivariate logistic regression analysis was utilized to analyses risk factors for spinal pain.Results: The whole cohort presented at least one level disc degeneration of Grade 2 in cervical or lumbar spine. 134 of 178 subjects (75.3%) showed at least one cervical disc degeneration in grade 3. 61 (34.3%) presented cervical disc bulging and 5 (3%) presented cervical disc protrusion. 110 (61.8%) aviators reported neck pain during the last 12 months. 53 of 178 (29.8%) volunteers had at least one lumbar disc degeneration in grade 3. 31 (17.4%) aviators presented lumbar disc bulging and 21 (11.8%) presented lumbar disc protrusion. 45 (25.3%) aviators reported back pain during the last 12 months. Multivariate logistic regression analysis showed age, cervical disc degeneration and bulging were risk factors for neck pain; lumbar disc degeneration, bulging and protrusion were risk factors for back pain. Conclusions: Moderate degrees of disc degenerative changes and diseases of spine could be found in new graduate aviators at an early age. Disc degeneration and diseases correlate strongly with spinal pain. It is essential to recognize these pathological conditions to intervene in the occurrence and development of degenerative changes in aviators in advance.

RISK FACTORS FOR LUMBAR DISC DEGENERATION: AN MRI ANALYSIS OF 130 HEALTHY VOLUNTEERS

Spine ◽  
2008 ◽  
Vol &NA; ◽  
pp. 101
Author(s):  
Masahiro Kanayama ◽  
Daisuke Togawa ◽  
Tomoya Terai ◽  
Tomoyuki Hashimoto ◽  
Keiichi Shigenobu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Healthy Volunteers ◽  
Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration

Young Investigator Award 2001 Winner: Risk Factors for Lumbar Disc Degeneration

Spine ◽  
2002 ◽  
Vol 27 (2) ◽  
pp. 125-134 ◽  
Author(s):  
Achim Elfering ◽  
Norbert Semmer ◽  
Daniel Birkhofer ◽  
Marco Zanetti ◽  
Juerg Hodler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
Young Investigator ◽  
Young Investigator Award

scholarly journals 080 LUMBAR DISC DEGENERATION AND GENETIC FACTORS ARE THE MAIN RISK FACTORS FOR LOW BACK PAIN: THE UK TWIN SPINE STUDY

2010 ◽  
Vol 18 ◽  
pp. S42
Author(s):  
G. Livshits ◽  
S. Ermakov ◽  
M. Popham ◽  
A.J. MacGregor ◽  
P.N. Sambrook ◽  
...  
Keyword(s):  
Risk Factors ◽  
Low Back Pain ◽  
Back Pain ◽  
Disc Degeneration ◽  
Genetic Factors ◽  
Lumbar Disc ◽  
Low Back ◽  
Lumbar Disc Degeneration ◽  
The Uk

scholarly journals Trans-ethnic polygenic analysis supports genetic overlaps of lumbar disc degeneration with height, body mass index, and bone mineral density

2018 ◽  
Author(s):  
Xueya Zhou ◽  
Ching-Lung Cheung ◽  
Tatsuki Karasugi ◽  
Jaro Karppinen ◽  
Dino Samartzis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Body Mass Index ◽  
Body Mass ◽  
Disc Degeneration ◽  
Bone Mineral ◽  
Lumbar Disc ◽  
Lipid Levels ◽  
Lumbar Disc Degeneration ◽  
Mineral Density

AbstractLumbar disc degeneration (LDD) is age-related break-down in the fibrocartilaginous joints between lumbar vertebrae. It is a major cause of low back pain and is conventionally assessed by magnetic resonance imaging (MRI). Like most other complex traits, LDD is likely polygenic and influenced by both genetic and environmental factors. However, genome-wide association studies (GWASs) of LDD have uncovered few susceptibility loci due to the limited sample size. Previous epidemiology studies of LDD also reported multiple heritable risk factors, including height, body mass index (BMI), bone mineral density (BMD), lipid levels, etc. Genetics can help elucidate causality between traits and suggest loci with pleiotropic effects. One such approach is polygenic score (PGS) which summarizes the effect of multiple variants by the summation of alleles weighted by estimated effects from GWAS. To investigate genetic overlaps of LDD and related heritable risk factors, we calculated the PGS of height, BMI, BMD and lipid levels in a Chinese population-based cohort with spine MRI examination and a Japanese case-control cohort of lumbar disc herniation (LDH) requiring surgery. Because most large-scale GWASs were done in European populations, PGS of corresponding traits were created using weights from European GWASs. We calibrated their prediction performance in independent Chinese samples, then tested associations with MRI-derived LDD scores and LDH affection status. The PGS of height, BMI, BMD and lipid levels were strongly associated with respective phenotypes in Chinese, although phenotype variances explained were lower than in Europeans which would reduce the power to detect genetic overlaps. Despite of this, the PGS of BMI and lumbar spine BMD were significantly associated with LDD scores; and the PGS of height was associated with the increased the liability of LDH. Furthermore, linkage disequilibrium score regression suggested that, osteoarthritis, another degenerative disorder that shares common features with LDD, also showed genetic correlations with height, BMI and BMD. The findings suggest a common key contribution of biomechanical stress to the pathogenesis of LDD and will direct the future search for pleiotropic genes.

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