scholarly journals Genetic Risk Factors for Idiopathic Urolithiasis: The Causative Role of Genes in Stones Formation

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Jatmiko Susilo
Keyword(s):  
Kidney Stone ◽  
Genetic Factors ◽  
Stone Formation ◽  
Review Article ◽  
Causative Role ◽  
Genetic Approach ◽  
Formation Method ◽  
Targeted Gene Therapy ◽  
Kidney Stone Formation

Background: The genetic factor of urolithiasis plays an important role in the etiology. Elucidation of responsible genes can lead to better targeted gene therapy and prevention in the future. This article aims to explain various genetic factors that play a role in kidney stone formation Method: A review article on urolithiasis based on a genetic approach is reported to underlie stone formation. A total of 41 abstracts and research articles published by internationally reputed journals were selected based on the keywords genetic factors and urolithiasis. Summary: A deeper understanding of the genetic factors that play a role in the mechanisms of stone formation and advances in molecular and pharmacogenomics have revolutionized diagnosis and treatment, and paved the way for the identification of new therapeutic targets and treatment approaches based on genetic engineering.

ROLE OF ANIONIC PROTEINS IN KIDNEY STONE FORMATION:

2000 ◽  
pp. 1343-1348 ◽  
Author(s):  
JEFFREY A. WESSON &NA; ◽  
ELAINE M. WORCESTER ◽  
JACK G. KLEINMAN
Keyword(s):  
Kidney Stone ◽  
Stone Formation ◽  
Kidney Stone Formation

The Potential Role of Salt Abuse on the Risk for Kidney Stone Formation

1993 ◽  
Vol 150 (2 Part 1) ◽  
pp. 310-312 ◽  
Author(s):  
Khashayar Sakhaee ◽  
Jean A. Harvey ◽  
Paulette K. Padalino ◽  
Peggy Whitson ◽  
Charles Y.C. Pak
Keyword(s):  
Kidney Stone ◽  
Potential Role ◽  
Stone Formation ◽  
Kidney Stone Formation

scholarly journals ALBUMIN AND ITS ROLE IN UROLITHIASIS

2017 ◽  
Vol 10 (10) ◽  
pp. 32 ◽  
Author(s):  
Devesh Raizada ◽  
Pragya Kumar ◽  
Tanya Singh ◽  
Trisha Pruthi ◽  
Riyadarshini Riyadarshini
Keyword(s):  
Fatty Acids ◽  
Organic Matter ◽  
Human Blood ◽  
Kidney Stone ◽  
Potential Role ◽  
Stone Formation ◽  
Multifactorial Disease ◽  
The Matrix ◽  
Kidney Stone Formation

Urolithiasis is a multifactorial disease with an incidence rate of more than one million cases reported annually in India. Various forms of the calculus have been reported to have 90-95% inorganic and 5% organic matter. Out of the major proteins that comprise this organic component of the matrix, albumin, and uromodulin are found to be the most abundant. Albumin is also the most abundant protein in the human blood serum where it plays the role of a transporter of hormones, fatty acids, and other compounds. The increased concentrations of albumin may significantly affect a patient’s susceptibility to kidney stone formation. The study of the role of albumin in urolithiasis could give us useful insights on its potential role in this disease and may add to the therapeutic repertoire of albumin.

scholarly journals Assessment of the role of general, biochemical and family history characteristics in kidney stone formation

2015 ◽  
Vol 22 (1) ◽  
pp. 65-68 ◽  
Author(s):  
Faiza Jabbar ◽  
Muhammad Asif ◽  
Hajirah Dutani ◽  
Abrar Hussain ◽  
Arif Malik ◽  
...  
Keyword(s):  
Family History ◽  
Kidney Stone ◽  
Stone Formation ◽  
Kidney Stone Formation

scholarly journals Paracellular calcium transport in the proximal tubule and the formation of kidney stones

2019 ◽  
Vol 316 (5) ◽  
pp. F966-F969
Author(s):  
Joshua N. Curry ◽  
Alan S. L. Yu
Keyword(s):  
Proximal Tubule ◽  
Kidney Stones ◽  
Calcium Transport ◽  
Kidney Stone ◽  
Stone Formation ◽  
Idiopathic Hypercalciuria ◽  
Recent Developments ◽  
Calcium Reabsorption ◽  
Kidney Stone Formation

The proximal tubule (PT) is responsible for the majority of calcium reabsorption by the kidney. Most PT calcium transport appears to be passive, although the molecular facilitators have not been well established. Emerging evidence supports a major role for PT calcium transport in idiopathic hypercalciuria and the development of kidney stones. This review will cover recent developments in our understanding of PT calcium transport and the role of the PT in kidney stone formation.

Role of the Renal Collecting System in Initial Kidney Stone Formation

1999 ◽  
Vol 13 (9) ◽  
pp. 601-604 ◽  
Author(s):  
PARAMJIT S. CHANDHOKE ◽  
JIE FAN ◽  
DONALD J. MAY ◽  
TAKASHI YAGISAWA
Keyword(s):  
Kidney Stone ◽  
Stone Formation ◽  
Kidney Stone Formation ◽  
Collecting System

scholarly journals The role of the microbiome in kidney stone formation

2016 ◽  
Vol 36 ◽  
pp. 607-612 ◽  
Author(s):  
Mansi Mehta ◽  
David S. Goldfarb ◽  
Lama Nazzal
Keyword(s):  
Kidney Stone ◽  
Stone Formation ◽  
Kidney Stone Formation

Possible Role of Carbohydrate-Induced Calciuria in Calcium Oxalate Kidney-Stone Formation

1969 ◽  
Vol 280 (5) ◽  
pp. 232-237 ◽  
Author(s):  
Jacob Lemann ◽  
Walter F. Piering ◽  
E. J. Lennon ◽  
Opal A. Kelly ◽  
Jean Brock
Keyword(s):  
Calcium Oxalate ◽  
Kidney Stone ◽  
Stone Formation ◽  
Kidney Stone Formation
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