Is entrepreneurship an emerging area of research? A computational response

Objective: We aim to answer four questions. First, with the increasing number of publications, is there a concentration in specific subjects, or on the contrary, a dispersion, amplifying the span of themes related to entrepreneurship? Second, is there a hierarchy of subjects, in the sense that some of them constitute the “core” of entrepreneurship? Third, are they connected with other established research areas? Finally, it is possible to identify papers that are influential, acting as hubs in the cluster’s formation? Method: We developed an original version of the computational procedure proposed by Shibata et al (2008), which allows us to understand the diversity of the different sub-areas of the topic investigated, reducing the need for specialist supervision. Originality / Relevance: We developed and applied a method to capture the formation and evolution of research areas in entrepreneurship literature, via direct citation networks, allowing us to understand the iteration between the different research sub-areas. Results: The dispersion is a feature of entrepreneurship as field research, with a hierarchy between research areas, indicating an emergent organization in the expansion processes. We concluded that research on entrepreneurship consists of specialization, that is, by application in niches.

Genetic Risk Factors for Idiopathic Urolithiasis: The Causative Role of Genes in Stones Formation

Background: The genetic factor of urolithiasis plays an important role in the etiology. Elucidation of responsible genes can lead to better targeted gene therapy and prevention in the future. This article aims to explain various genetic factors that play a role in kidney stone formation Method: A review article on urolithiasis based on a genetic approach is reported to underlie stone formation. A total of 41 abstracts and research articles published by internationally reputed journals were selected based on the keywords genetic factors and urolithiasis. Summary: A deeper understanding of the genetic factors that play a role in the mechanisms of stone formation and advances in molecular and pharmacogenomics have revolutionized diagnosis and treatment, and paved the way for the identification of new therapeutic targets and treatment approaches based on genetic engineering.

Choosing a methodological base for forming and accounting for the construction costs of a gas well at the final stage of field development

The article introduces the problems of choosing a methodological base for forming and accounting costs during well construction, taking into account the intensification of gas inflow at the final stage of field development. The main methods that allow taking into account the costs of drilling operations are outlined. The main costs that need to be taken into account when designing fields with hard-to-recover gas reserves are identified and characterized. The main stages of cost formation by construction phases of a gas-producing well are shown, as well as the factors influencing the level and structure of the cost price during the construction of a well are highlighted. The authors consider the classification of cost accounting methods in the context of the comparison criterion and present the possible results of the correct choice of the cost formation method during the construction of a gas well at the final stage of its development.

Formulation Development and Evaluation of Migraine Almotriptan Loaded Ethosomes Using Box Behnken Design

One of the most common nervous system illnesses is headache disorders, which are characterized by chronic headaches. In Present investigation Almotriptan loaded Ethosomes were prepared by water phase addition method. The three independent factors including Phosphotidylcholine: Cholestrol: DSPE (6:3:1molar ratio), Surfactant concentration and sonication time. A factorial design 3*3(3 factor 3 level) was applied to prepare 17 formulation. Optimization of ethosomal preparation was carried out by applying Box Behnken response surface randomized factorial design following quadratic model using Design of Experiment (DOE) software version 11.04.0. The factor Soya PC: Cholesterol: DSPE in molar ration (6:3:1), Concentration of Tween-80 and sonication time were selected as dependable process and formulation factors that can be effect formulation characteristics like entrapment efficiency, average vesicle size, Polydispersity Index (PDI). All other factors like sonication speed and rotation speed was kept constant All the formulation were prepared by simple solvent evaporation thin film formation method and characterized for the drug entrapment, average vesicle size and PDI, shape morphology. Formulations were optimized on the basis of responses such as average vesicle size, PDI, and entrapment efficiency. All the characterized values of the responses were putted in the formulation design table and analyse to best fitted model for the design. It was observed that, quadaratic model is best fitted model for the design. The prepared ethosomes formulation can further incorporated in situ gel for effective treatment of migraine.

Simulation and Analysis of Grid Formation Method for UAV Clusters Based on the 3 × 3 Magic Square and the Chain Rules of Visual Reference

Large-scale unmanned aerial vehicle (UAV) formations are vulnerable to disintegration under electromagnetic interference and fire attacks. To address this issue, this work proposed a distributed formation method of UAVs based on the 3 × 3 magic square and the chain rules of visual reference. Enlightened by the biomimetic idea of the plane formation of starling flocks, this method adopts the technical means of airborne vision and a cooperative target. The topological structure of the formation’s visual reference network showed high static stability under the measurement of the network connectivity index. In addition, the dynamic self-healing ability of this network was analyzed. Finally, a simulation of a battlefield using matlab showed that, when the loss of UAVs reaches 85% for formations with different scales, the UAVs breaking formation account for 5.1–6% of the total in the corresponding scale, and those keeping formation account for 54.4–65.7% of the total undestroyed fleets. The formation method designed in this paper can maintain the maximum number of UAVs in formation on the battlefield.

circ_0075943 Dominates the miR-141-3p/AK2 Network to Support the Development of Breast Carcinoma

Background. Breast cancer (BC) progression is related to the disorder of circular RNAs (circRNAs). This study aims to characterize the role of circ_0075943 in BC. Methods. Real-time fluorescent quantitative PCR (real-time PCR) technology was implemented to investigate circ_0075943, AK2 mRNA, and microRNA-141-3p levels. MTT, colony formation method, Transwell, and flow cytometry technique were adopted to investigate cell function. The connection between miR-141-3p and circ_0075943 or AK2 was confirmed by the dual-luciferase reporter gene or RNA immunoprecipitation (RIP). The influence on circ_0075943 in vivo was confirmed by animal experiments. Results. circ_0075943 was augmented in BC cell lines and tumor specimens. Dwindling of circ_0075943 could dramatically suppress the phenotype of BC cells and induce apoptosis. MiR-141-3p is a target of circ_0075943, and its repression largely reverses the influence of knocking down circ_0075943 on cell behavior. Moreover, AK2, as a target of miR-141-3p, is augmented in BC cells and specimens. AK2 overexpression could restore the phenotype of BC cells blocked by miR-141-3p redevelopment. Moreover, knocking down circ_0075943 could suppress the growth of tumors in vivo. Conclusion. The abnormal regulation of circ_0075943 participates in part of the expansion of BC by dominating the miR-141-3p/AK2 regulatory network.

SEEKING THE MARKS OF KNITTING WITHIN THE HISTORY: NALBINDING

Being a textile surface formation method basing on binding and passing the loops prepared separately with an assistant such as crochet needle, knitting needle or shuttle and coming from the ball through one another, weft knitted fabric’s development process within the history has mostly been associated with hand-knit started with knitting needles. Together with this, scientific examinations and dating methods conducted on the needles and breadths brought out in the archaeological digs carried out world-wide proves that the commencement of hand-knit within the history dates back older times. The findings came up in archaeological digs show that knitting began with world-widely known nalbinding technique or single needle knitting. Nalbinding is based on binding the loops formed with needle and thread to one another in the form of a cyclic hoop within themselves. Although nalbinding is expressed in several Turkish resources related to knitting, it is an old technique that is not commonly used. This technique used in Northern Europe shows similarity with shuttled knitting, fishnet knitting, point lace techniques commonly known in Anatolia and in terms of formation of surface with thread hoop and usage of single thread carrier. Even though nalbinding technique is not common in Anatolia, the fact that some needles thought to have been used as knitting needle were found in the recent archaeological digs (Başur Höyük–Siirt, Körtik Tepe-Diyarbakır) makes us consider that the history of knitting dates back to 11.000 BC in these lands and knitting technique made by using knitting needle might have been used in Anatolia. Besides this, there is not an assessment on whether nalbinding was used in Turkey or not. It is observed that there is an increasing interest in nalbinding technique, which is used for gloves, socks and knit cap around the world since 1970s. Revival of this technique in Scandinavian countries is in question. For that reason, this research was designed for the ones showing interest to textile design techniques as a collection to introduce the history and technique of nalbinding technique, and its needles over knitting needles found out in recent archaeological digs conducted in Turkey and around the world. Keywords: Knitting, nalbinding, single needle knitting, knitting in archaeological digs, knitting textile findings

ANALISIS BENTUK DAN MAKNA JAM’ AL TAKSĪR DALAM ALQURAN JUZ 29 DAN 30 (ANALISIS MORFOLOGIS DAN SEMANTIS)

Broken plural is one of three plural study of arabic. It has special character whose make it different. Two other plural (intact masculine plural and intact feminine plural) have constant alteration of accidence measure, while it hasn’t. It has complex alteration measure. Alteration of this plural happend through augmentation, elimination, and by changing it’s vowel. Purpose of this research is to know derivate, formation method, and meaning from semantics sector of broken plural on the koran juz 29 and 30. This research is qualitative research with library research design. Data on this research are all of broken plural on the koran juz 29 and 30. Data aggregation of this research use documentation method with data card and recapitulation thread in instrument. Result of this research is from 92 data, 28 data are minor plural, 37 data are major plural, and 27 data are ultimate plural form. Based on semantics, 41 data have constant meaning, 11 data have generalization meaning, 28 data have constrict meaning, and 12 data have changing meaning.

Immobilization of Baeyer-Villiger monooxygenase from acetone grown Fusarium sp.

ObjectiveA novel biocatalyst for Baeyer–Villiger oxidations is necessary for pharmaceutical and chemical industries, so this study aims to find a Baeyer–Villiger monooxygenase (BVMO) and to improve its stability by immobilization. ResultsAcetone, the simplest ketone, was selected as the only carbon source for the screening of microorganisms with a BVMO. A eukaryote, Fusarium sp. NBRC 109816, with a BVMO ( F BVMO), was isolated from a soil sample. F BVMO was overexpressed in E. coli and successfully immobilized by the organic-inorganic nanocrystal formation method. The immobilization improved the thermostability of F BVMO. Substrate specificity investigation revealed that both free and immobilized F BVMO were found to show catalytic activities not only for Baeyer–Villiger oxidation of ketones to esters but also for oxidation of sulfides to sulfoxides. Furthermore, a preparative scale reaction using immobilized F BVMO was successfully conducted. ConclusionsFBVMO was discovered from an environmental sample, overexpressed in E. coli , and immobilized by the organic-inorganic nanocrystal formation method. The immobilization successfully improved its thermostability.