scholarly journals PERKEMBANGAN KONSEP PATOGENESIS ATEROSKLEROSIS

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Poppy Lintong
Keyword(s):  
Inflammatory Disease ◽  
Endothelial Permeability ◽  
Chronic Inflammatory Disease ◽  
Endothelial Injury ◽  
Fatty Streak ◽  
Key Words Atherosclerosis ◽  
Molecular Responses ◽  
Endothelial Homeostasis ◽  
Injury Causes ◽  
Vascular Myocytes

Abstract: Nowadays, the concept of the pathogenesis of atherosclerosis is called a response to injury hypothesis. This is based on the fact that atherosclerosis is a chronic inflammatory disease induced by endothelial injury (endothelial dysfunction). This chronic inflammatory disease consists of sequences of cellular and molecular responses, and is induced and accelerated mainly by endothelial injury. Furthermore, this injury causes compensatory responses which change the endothelial homeostasis, and increases the endothelial permeability and adhesion of leucocytes or platelets to endothelial cells. Many factors can trigger this endothelial injury, but the most important ones are haemodynamic imbalance and hypercholesterolemia. Besides these, vascular myocytes, together with extracellular matrix, play some significant roles in developing fatty streaks to become atheroma plaques. Key words: atherosclerosis, endothelial injury, lipid, chronic inflammation, vascular myocytes.     Abstrak: Konsep patogenesis aterosklerosis saat ini disebut hipotesis respons terha-dap cedera.  Konsep ini mengacu pada aterosklerosis sebagai penyakit radang kronik yang diinduksi oleh cedera endotel (disfungsi endotel). Proses radang kronik pada aterosklerosis terdiri dari rangkaian  respons seluler dan molekuler. Sebagai faktor utama yang dapat menginduksi dan memacu proses radang disini adalah cedera endotel. Adanya cedera endotel menyebabkan terjadinya respons kompensatorik yang mengubah homeostasis endotel serta meningkatkan permeabilitas endotel dan adhesi lekosit atau trombosit terhadap endotel. Banyak faktor dapat mencetuskan terjadinya cedera endotel namun yang terpenting adalah gangguan hemodinamik dan hiperkolesterolemia. Selain itu sel otot polos pembuluh darah juga turut berperan dalam aterogenesis yang bersama-sama dengan matriks ekstrasel mengubah fatty streak menjadi bercak ateroma. Kata kunci: aterosklerosis, cedera endotel, lemak, radang kronis, otot polos pembuluh darah.

A Critical Review on Tamaka Shwasa (Bronchial Asthma) - An Ayurvedic View

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Sandip R. Baheti ◽  
Deepa Sharma ◽  
Saroj Devi ◽  
Amit Rai
Keyword(s):  
Bronchial Asthma ◽  
Inflammatory Disease ◽  
Critical Review ◽  
Modern Science ◽  
Modern Medicine ◽  
Chronic Inflammatory Disease ◽  
The Body ◽  
Natural Immunity ◽  
Shortness Of Breath ◽  
Asthma Symptoms

Difficulty in breathing or shortness of breath may be simply termed as Shwasa (Asthma), As per Ayurveda, Shwasa is mainly caused by the Vata and Kapha Doshas. Shwasa is broadly classified into five types in Maha Shwasa (Dyspnoea major), Urdhawa Shwasa (Expiratory Dyspnoea), Chinna Shwasa (Chyne-stroke respiration), Kshudra Shwasa (Dyspnoea minor), Tamaka Shwasa (Bronchial Asthma). In modern science Tamaka Shwasa can be correlated with Asthma, Asthma which is a chronic inflammatory disease of airway. In modern medicine there is no cure for Asthma, symptoms can typically be improved. In Ayurveda, Asthma can be effectively and safely manage the condition without inducing any drug dependency where Pachakarma procedures and use of internal medication detoxifies the body, provides nutrition and increases the elasticity of lung tissue it also develops natural immunity of the body thus decreasing episodic recurrence of the disease.

Intermammary Hidradenitis Suppurativa: Considerations on a Unique Presentation

2021 ◽  
pp. 1-4
Author(s):  
Ana Luísa João ◽  
Nélia Cunha ◽  
Joana Cabete
Keyword(s):  
Surgical Approach ◽  
Inflammatory Disease ◽  
Pilonidal Sinus ◽  
Hidradenitis Suppurativa ◽  
Chronic Inflammatory Disease ◽  
Pilonidal Sinus Disease ◽  
Sinus Disease ◽  
Case Presentation ◽  
Overweight Women

Introduction: Hidradenitis suppurativa (HS) is a potentially disabling chronic inflammatory disease. The intermammary location, not clearly specified in the usual phenotypic classifications, entails significant functional and cosmetic compromise. Case Presentation: Eleven cases of predominantly intermammary disease with multiple fistulization and disfiguring scarring were observed at our Department between January 2016 and March 2020. They were young (mean age = 22 years) obese or overweight women, in which the medical-surgical approach has led to variable results. Discussion/Conclusion: Intermammary HS possibly represents a unique phenotypic presentation, likely to be fistulizing and severe. We believe that anatomo-functional considerations, which can be paralleled to pilonidal sinus disease, contribute to its pathophysiology and striking appearance, and further emphasize the importance of multidisciplinary endeavor to reduce the morbidity associated with this seemingly overlooked location.

708 FREQUENCY OF HYPERTENSION IN PATIENTS WITH CHRONIC INFLAMMATORY DISEASE S IS UNDERESTIMATED

2012 ◽  
Vol 30 ◽  
pp. e205-e206
Author(s):  
Ingrid Prkacin ◽  
Diana Balenovic ◽  
Andrija Jurina ◽  
Luka Šantek ◽  
Dino Kasumović ◽  
...  
Keyword(s):  
Inflammatory Disease ◽  
Chronic Inflammatory Disease

An efficient treatment of biofilm-induced periodontitis using Pt nanoclusters catalysis

Nanoscale ◽  
2021 ◽  
Author(s):  
Tao Wu ◽  
Jiahui Sun ◽  
Jie Lei ◽  
Qihang Fan ◽  
Xiuyu Tang ◽  
...  
Keyword(s):  
Bone Loss ◽  
Inflammatory Disease ◽  
Biofilm Formation ◽  
Tooth Loss ◽  
Gingival Recession ◽  
Chronic Inflammatory Disease ◽  
Efficient Treatment ◽  
Pt Nanoclusters

Periodontitis is a common chronic inflammatory disease associated with biofilm formation, gingival recession, and supporting bone loss that can lead to the formation of periodontal pockets and, ultimately, tooth loss....

Animal hair as a rare cause of pilonidal sinus – a case report

Nowa Medycyna ◽  
2018 ◽  
Vol 25 (4) ◽  
Author(s):  
Paweł Dutkiewicz ◽  
Przemysław Ciesielski
Keyword(s):  
Case Report ◽  
Inflammatory Disease ◽  
Pilonidal Sinus ◽  
Human Hair ◽  
Clinical Case ◽  
Chronic Inflammatory Disease ◽  
Animal Origin ◽  
Safe Procedure ◽  
The World ◽  
Animal Hair

Pilonidal sinus is a chronic inflammatory disease caused by the penetration of hair into the skin. Most often, it is located in the intergluteal area, but it may also develop at a different location. It is usually caused by the penetration of human hair, but animal hair can alaso cause it in rare cases. In the world publications, there are reports of the disease in other, often distant locations, e.g. the suprapubic area, armpit, foot, penis, umbilicus, eyelid, clitoris, intermammary cleft, nose, or scar after removing a Tenckhoff catheter. Usually, it is human hair that causes the formation of pilonidal sinus, but the literature also reports cases caused by animal hair in people who shear sheep. There is no other Polish publication describing pilonidal sinus of animal origin. The article presents a case of atypical pilonidal sinus caused by animal hair, located between the fingers of the patient who is professionally involved in shearing dogs. In the presented clinical case, treatment involved staged fistulotomy with the use of surgical thread. The patient was cured and full function of the hand was preserved. Staged fistulotomy is a safe procedure and can be used to treat pilonidal sinus of the hand.

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