scholarly journals MIXED GERM CELL-SEX CORD-STROMAL TUMORS

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Poppy M. Lintong
Keyword(s):  
Germ Cell ◽  
Germ Cells ◽  
Stromal Tumor ◽  
Stromal Tumors ◽  
Unusual Phenomenon ◽  
Microscopic Features ◽  
Germinal Cells ◽  
Histopathologic Feature ◽  
Sex Cord Stromal Tumors ◽  
Sex Cord Stromal Tumor

Abstract: The term mixed germ cell sex-cord-stromal tumors is used for a mixed tumor containing mixed germ cells and sex-cord-stromal tumors. In pathology, this is an unusual phenomenon because although the tumor has several components, the histopathologic feature is still as a single unit. The most frequent form of mixed germ cell and sex-cord-stromal tumors is gonadoblastoma. This tumor usuallly occurs in sexual development abnormality, and can be found either in ovarium or testis. The basic microscopic features of this tumor are a mixture of dysgerminoma-like primitive germinal cells, and granulosa and immature Sertoli like cells of the sex-cord-stromal tumor. Besides gonadoblastoma, there is an unclassified tumor consisting of mixed germ cells and sex-cord-stromal tumor which cover all tumors containing a mixture of germinal cells and sex-cords but its cellular characteristics differ from gonadoblastoma. Keywords: mixed germ cell, sex cord-stromal tumors, gonadoblastoma.   Abstrak: Istilah mixed germ cell - sex cord-stromal tumors sering digunakan untuk tumor campuran mixed germ cell dan sex cord-stromal tumors. Dalam bidang patologi hal ini merupakan suatu fenomena luar biasa karena  meskipun terdapat beberapa komponen tumor  namun tetap memberikan gambaran histopatologik sebagai suatu kesatuan tunggal. Bentuk paling sering dari mixed germ cell - sex cord-stromal tumors ialah gonadoblastoma. Gonadoblastoma sering ditemukan pada individu dengan perilaku seksual tidak normal. Selain pada ovarium, tumor ini juga dapat ditemukan pada testis. Gambaran mikroskopik yang mendasar dari tumor ini ialah campuran dari sel-sel germinal primitif menyerupai disgerminoma dan sel stroma sex-cord menyerupai sel-sel granulosa dan sertoli imatur. Selain gonadoblastoma, juga terdapat mixed germ cell - sex cord-stromal tumors unclassified yang mencakup semua tumor yang mengandung campuran bermacam-macam sel germinal dan sex-cord namun karakteristik selulernya tidak  serupa dengan gonadoblastoma. Kata kunci: mixed germ cell, sex cord-stromal tumors, gonadoblastomsa.

scholarly journals Preoperative Differentiation of Benign and Malignant Non-epithelial Ovarian Tumors: Clinical Features and Tumor Markers

2020 ◽  
Vol 42 (09) ◽  
pp. 555-561
Author(s):  
Tiago Augusto Gomes ◽  
Elizabeth Aparecida Campos ◽  
Adriana Yoshida ◽  
Luís Otavio Sarian ◽  
Liliana Aparecida Lucci de Angelo Andrade ◽  
...  
Keyword(s):  
Germ Cell ◽  
Clinical Features ◽  
Germ Cell Tumors ◽  
Serum Levels ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Stromal Tumors ◽  
Fertility Sparing ◽  
Sex Cord Stromal Tumors ◽  
Sex Cord Stromal Tumor

Abstract Objective To evaluate the role of clinical features and preoperative measurement of cancer antigen 125 (CA125), human epididymis protein (HE4), and carcinoembryonic antigen (CEA) serum levels in women with benign and malignant non-epithelial ovarian tumors. Methods One hundred and nineteen consecutive women with germ cell, sex cord-stromal, and ovarian leiomyomas were included in this study. The preoperative levels of biomarkers were measured, and then surgery and histopathological analysis were performed. Information about the treatment and disease recurrence were obtained from the medical files of patients. Results Our sample included 71 women with germ cell tumors (64 benign and 7 malignant), 46 with sex cord-stromal tumors (32 benign and 14 malignant), and 2 with ovarian leiomyomas. Among benign germ cell tumors, 63 were mature teratomas, and, among malignant, four were immature teratomas. The most common tumors in the sex cord-stromal group were fibromas (benign) and granulosa cell tumor (malignant). The biomarker serum levels were not different among benign and malignant non-epithelial ovarian tumors. Fertility-sparing surgeries were performed in 5 (71.4%) women with malignant germ cell tumor. Eleven (78.6%) patients with malignant sex cord-stromal tumors were treated with fertility-sparing surgeries. Five women (71.4%) with germ cell tumors and only 1 (7.1%) with sex cord-stromal tumor were treated with chemotherapy. One woman with germ cell tumor recurred and died of the disease and one woman with sex cord-stromal tumor recurred. Conclusion Non-epithelial ovarian tumors were benign in the majority of cases, and the malignant cases were diagnosed at initial stages with good prognosis. The measurements of CA125, HE4, and CEA serum levels were not useful in the preoperative diagnosis of these tumors.

Mixed Germ Cell-Sex Cord Stromal Tumor of Testis: Incidental Finding of Rare Testicular Neoplasm

1995 ◽  
Vol 154 (4) ◽  
pp. 1479-1479 ◽  
Author(s):  
Ross A. Rames ◽  
Mary Richardson ◽  
Frederick Swiger ◽  
Anthony Kaczmarek
Keyword(s):  
Germ Cell ◽  
Incidental Finding ◽  
Stromal Tumor ◽  
Testicular Neoplasm ◽  
Sex Cord Stromal Tumor

Non-Epithelial Ovarian Cancer; NCI Study

2020 ◽  
Vol 106 (1_suppl) ◽  
pp. 7-7
Author(s):  
Ashraf Sobhy ◽  
Mohammed Gamil ◽  
Omar Youssef ◽  
Ali Hassan Mebed
Keyword(s):  
Ovarian Cancer ◽  
Germ Cell ◽  
Epithelial Ovarian Cancer ◽  
Germ Cell Tumors ◽  
Disease Stage ◽  
Early Stage Disease ◽  
Stromal Tumors ◽  
Ovarian Cancers ◽  
Malignant Germ Cell Tumors ◽  
Sex Cord Stromal Tumors

Background: Non-epithelial cancers of the ovary are uncommon. They include malignancies of germ cell origin, sex cord-stromal cell origin, metastatic carcinomas to the ovary, and a variety of extremely rare ovarian cancers, such as sarcomas and lipoid cell tumors. Nonepithelial malignancies account for about 10% of all ovarian cancers. Objective: To review the management of Non-epithelial ovarian cancer in the NCI Cairo university during a period of 5 years (2005 till 2010). Material and Methods: Retrospective study including 114 patients who were diagnosed and treated with Non-epithelial ovarian cancer (2005 to 2010). Data were collected from the biostatistics and cancer epidemiology department. Results: Out of 114 patients; 25(21.9%) were benign and 25 (21.9%) were borderline malignant; 55 (48.2%) were malignant and 9 (7.89%) of them were unpredicted biologic behavior; the median age of the study population was 49.7 years (range 14_83years). Panhysterectomy was done in 77(67.5%) of the patients; ovariectomy and debulking were done in 22(19.3%; salpingooophorectomy was done in 10(8.8%) 0f patients and cystectomy was done in 3(2.6%) and 2 cases underwent biopsy. Conclusion: Sex cord-stromal tumors and malignant germ cell tumors are the most common nonepithelial ovarian cancers. These tumors often, but not always, present with the sequelae of overproduction of either androgens or estrogens. It is important to diagnose these masses early, as overall prognosis is typically very good for early stage disease in all histological subtypes. Both sex cord-stromal tumors and malignant germ cell tumors of the ovary are treated with initial surgical resection. Fertility sparing surgery can be considered for both sex cord-stromal and malignant germ cell tumors of the ovary. Depending on the pathological diagnosis and disease stage, postoperative management consists of either expectant management or adjuvant chemotherapy. It is recommended that all patients with nonepithelial ovarian cancer be monitored for evidence of disease recurrence on a standardized schedule.

Germ Cell Tumors and Mixed Germ Cell-Sex Cord-Stromal Tumors of the Ovary

2019 ◽  
pp. 231-271 ◽  
Author(s):  
Hao Chen ◽  
Charles Matthew Quick ◽  
Oluwole Fadare ◽  
Wenxin Zheng
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Stromal Tumors ◽  
Sex Cord Stromal Tumors

scholarly journals Distribution of various histopathological types of ovarian tumors: A study of 212 cases from a tertiary care center of Eastern Uttar Pradesh

2019 ◽  
Vol 11 (01) ◽  
pp. 075-081 ◽  
Author(s):  
Neha Gupta ◽  
Mahima Yadav ◽  
Vikas Gupta ◽  
Deepshikha Chaudhary ◽  
Shashikant C. U. Patne
Keyword(s):  
Germ Cell ◽  
Who Classification ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Germ Cell Tumors ◽  
Serous Cystadenoma ◽  
Ovarian Tumors ◽  
Care Hospital ◽  
Stromal Tumors ◽  
Sex Cord Stromal Tumors

Abstract BACKGROUND: Ovarian tumors are one of the leading cancers in females with variable pathological types. This study describes the distribution, clinical and pathological details of various histopathological types of ovarian tumors in a tertiary care hospital in North India. MATERIALS AND METHODS: A retrospective data of 3 years were collected for ovarian tumors submitted to the pathology department of a tertiary care hospital. Data were classified according to the latest World Health Organization (WHO) Classification into epithelial tumors, germ cell tumors, sex cord–stromal tumors, and others. RESULTS: A total of 212 cases of ovarian tumors were studied, 186 were unilateral and 26 were bilateral. Resection specimen, part of specimen, and block review formed 80.2%, 15.1%, 4.7%, respectively. Epithelial tumors formed the majority in 71.7% of cases followed by germ cell tumors (22.2%), sex cord–stromal tumors (3.8%) and others (2.3%). Maximum number of cases in the respective groups occurred in the age groups 31–40, 21–30, 51–60, and 41–50 years, respectively. Overall, benign tumors were 63.7%, malignant tumors were 31.1%, and borderline were 5.2%. The most common histopathological type of benign and malignant tumor was benign serous cystadenoma (18.8%) and serous carcinoma (9.9%), respectively. CONCLUSION: In the present study, ovarian tumors were classified according to the WHO classification, epithelial and germ cell tumors were the major types of ovarian tumors. Benign epithelial tumor formed the majority with 46.2% cases. Serous cystadenoma and mature cystic teratoma were the predominant type of epithelial and germ cell tumors, respectively.

Bilateral Testicular Germ Cell–Sex Cord–Stromal Tumor in a Pekin Duck (Anas platyrhynchos domesticus)

2008 ◽  
Vol 22 (4) ◽  
pp. 315-319 ◽  
Author(s):  
Stacey Leach ◽  
J Jill Heatley ◽  
Roy Ransom Pool ◽  
Kathy Spaulding
Keyword(s):  
Germ Cell ◽  
Anas Platyrhynchos ◽  
Stromal Tumor ◽  
Pekin Duck ◽  
Testicular Germ Cell ◽  
Sex Cord Stromal Tumor
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