scholarly journals Penyakit Crohn: Laporan Kasus

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Paul V. Siwy ◽  
Fandy Gosal

Abstract: Crohn’s disease is an inflammatory transmural bowel disease with unspecific clinical characteritics. It could involve all parts of the digestive system. The exact cause of this disease remains unknown. Its manifestation depends on the location of involved intestinal mucosa, however, it could also occur extra intestinal. We reported a case of Crohn’s disease in a 54-year-old male. In this patient there was defecation with blood in stool, abdominal pain, nausea, and weight loss. Diagnosis was based on history, physical examination, endoscopic examination and colonoscopy, as well as histopathological examination. Colonoscopy EGD examination and tissue biopsy were performed on this patient and revealed esophagitis EGD classification of Los Angeles grade A and erosive gastritis. The results of colonoscopy suggested Crohn’s disease, and internal and external hemorrhoids. Pathology examination showed non-specific chronic gastritis, nonspecific chronic ileitis with datia cells, nonspecific pancolitis, and specific chronic proctitis. Disease activity measured by using CDAI (Crohn Disease Activity Index) score was 170 (mild disease). Moreover, based on the Montreal classification it was classified as A3 L3 B1 and SES-CD (Simple Endoscopic Scoring System in Crohn’s Disease) with value of 0 (not active). This patient was planned to be treated with 500 mg of mesalazine three times daily.Keywords: Crohn’s disease Abstrak: Penyakit Crohn adalah bagian dari penyakit inflamasi saluran cerna dengan karakteristik klinis yang tidak jelas, transmural, dan dapat mengenai semua bagian saluran cerna. Sampai saat ini etiologinya belum diketahui pasti. Manifestasi penyakit ini bervariasi tergantung kerusakan dari lokasi mukosa intestinal yang terkena. Manifestasi ini dapat juga terjadi di luar sistem saluran cerna. Kami melaporkan suatu kasus penyakit Crohn pada seorang laki-laki berusia 54 tahun. Pada pasien ini didapatkan buang air besar disertai darah, nyeri perut, mual dan penurunan berat badan. Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik, pemeriksaan endoskopi dan kolonoskopi serta pemeriksaan histopatologik. Pemeriksaan EGD-kolonoskopi dan biopsi jarring-an dengan hasil EGD esofagitis klasifikasi Los Angeles grade A dan gastritis erosiva. Hasil kolonoskopi ialah kesan suspek penyakit Crohn dengan hemoroid interna dan eksterna. Hasil histopatologi mendapatkan gastritis kronik non spesifik, ileitis kronik non spesifik dengan sel datia, pankolitis non spesifik dan proktitis kronik non spesifik. Aktivitas penyakit diukur dengan skor CDAI sebesar 170 (aktivitas ringan) dan berdasarkan klasifikasi Montreal diklasifikasikan sebagai A3 L3 B1 dan SES-CD sebesar 0 (tidak aktif). Pasien ini direncanakan untuk diterapi dengan pemberian mesalasin 500mg tiga kali sehari.Kata kunci: penyakit Crohn

2018 ◽  
Vol 56 (10) ◽  
pp. 1267-1275 ◽  
Author(s):  
Angelika Hüppe ◽  
Jana Langbrandtner ◽  
Winfried Häuser ◽  
Heiner Raspe ◽  
Bernd Bokemeyer

Abstract Introduction Assessment of disease activity in Crohn’s disease (CD) and ulcerative colitis (UC) is usually based on the physician’s evaluation of clinical symptoms, endoscopic findings, and biomarker analysis. The German Inflammatory Bowel Disease Activity Index for CD (GIBDICD) and UC (GIBDIUC) uses data from patient-reported questionnaires. It is unclear to what extent the GIBDI agrees with the physicians’ documented activity indices. Methods Data from 2 studies were reanalyzed. In both, gastroenterologists had documented disease activity in UC with the partial Mayo Score (pMS) and in CD with the Harvey Bradshaw Index (HBI). Patient-completed GIBDI questionnaires had also been assessed. The analysis sample consisted of 151 UC and 150 CD patients. Kappa coefficients were determined as agreement measurements. Results Rank correlations were 0.56 (pMS, GIBDIUC) and 0.57 (HBI, GIBDICD), with p < 0.001. The absolute agreement for 2 categories of disease activity (remission yes/no) was 74.2 % (UC) and 76.6 % (CD), and for 4 categories (none/mild/moderate/severe) 60.3 % (UC) and 61.9 % (CD). The kappa values ranged between 0.47 for UC (2 categories) and 0.58 for CD (4 categories). Discussion There is satisfactory agreement of GIBDI with the physician-documented disease activity indices. GIBDI can be used in health care research without access to assessments of medical practitioners. In clinical practice, the index offers a supplementary source of information.


2003 ◽  
Vol 40 (3) ◽  
pp. 198-200 ◽  
Author(s):  
Flavio Steinwurz

RACIONAL - OBJETIVO: Avaliar a eficácia do infliximab no tratamento de pacientes com doença de Crohn ativa ou com fístulas. MÉTODOS: Quarenta e quatro portadores de doença de Crohn, refratários ao tratamento convencional, foram tratados com infliximab, na dose de 5 mg/kg, através de infusão endovenosa. RESULTADOS: Trinta deles (68,2%) obtiveram melhora dos sintomas, com regressão importante nos níveis de atividade da doença, medidos pelo CDAI (Crohn's Disease Activity Index). Oito (57,1%) de 14 portadores de fístulas também obtiveram bons resultados, com fechamento ou importante diminuição do fluxo destas. A tolerância à droga foi boa em todos os casos. CONCLUSÃO: O uso de infliximab nestes casos parece ser boa opção terapêutica, com baixos índices de efeitos colaterais.


2014 ◽  
Vol 146 (5) ◽  
pp. S-174
Author(s):  
Itta Minderhoud ◽  
Ewout W. Steyerberg ◽  
Adriaan A. Van Bodegraven ◽  
Christien J. van der Woude ◽  
Daniel W. Hommes ◽  
...  

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