scholarly journals MICROBIOLOGICAL PROFILE IN PATIENTS WITH CONGENITAL NASO LACRIMAL DUCT OBSTRUCTION

2020 ◽  
pp. 1-4
Author(s):  
N. V. N Prasanna Bharathi ◽  
P. Ramdas ◽  
M. Padma ◽  
Sowmya Andole
Keyword(s):  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
Gram Positive ◽  
Congenital Nasolacrimal Duct Obstruction ◽  
Gram Negative ◽  
Duct Obstruction ◽  
Gram Positive Bacteria ◽  
Silicon Tube ◽  
Mixed Bacteria ◽  
A Prospective Study

AIM: To study and evaluate the different organisms that are responsible for congenital nasolacrimal duct obstruction .To initiate appropriate antimicrobials based on the sensitivity patterns of the isolated organisms. Methods: It is a prospective study conducted in Sarojini Devi Eye hospital during September 2016 to February 2018. 112 samples from 100 cases were collected from clinically diagnosed congenital nasolacrimal duct obstruction with epiphora below 1 year without any ocular and systemic diseases .Swabs taken were analysed for causative microorganisms of congenital nasolacrimal duct obstruction. Results: In our study out of 112 samples[88 unilateral cases+12 bilateral cases ]82 cases [73.21%] were culture positive, of which80 [71.42%]were bacterial,2 cases [1.78%]were mixed [ bacterial +fungal].Gram positive bacteria were predominant, staphylococcus epidermidis 56[68.29%] followed by Staphylococcus aureus 13[15.85%].Among gram negative bacteria Escherichia coli 1 [1.21%], klebsiella 1[1.21%]. 2 cases were mixed [bacteria +fungal]. Infection is more commonly seen in right eye. Rate of infection was higher in females 62[55.35].Higher incidence of infection was seen in the age group of less than 7 months. Both gram positive and gram negative were most susceptible to tobramycin. Conclusion: Among all the congenital nasolacrimal duct obstructions 90% of the cases would resolve spontaneously with medical therapy and Criggler massage. 10 % of the cases require probing and silicon tube intubation. The knowledge of identification , awareness and bacteriology of congenital nasolacrimal duct obstruction by the paediatricians , physicians and the parents would contribute to the choice of effective antimicrobials and reduce keratitis medicamentosa ,induced astigmatism due to excessive eye rubbing and apprehension among the parents.

scholarly journals Lacrimal Sac Bacteriology and Susceptibility Pattern in Infants with Congenital Nasolacrimal Duct Obstruction in the 1st Year of Life: A Cross-Sectional Study

2020 ◽  
Author(s):  
Xiaoyu Zheng ◽  
Bonnie Nga Kwan Choy ◽  
Mingming Zhou ◽  
Caiping Shi ◽  
Zhengyan Zhao
Keyword(s):  
Tertiary Care ◽  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
Chinese Children ◽  
First Year ◽  
Lacrimal Sac ◽  
Gram Positive ◽  
Congenital Nasolacrimal Duct Obstruction ◽  
Gram Negative ◽  
Duct Obstruction

Abstract Background: Congenital nasolacrimal duct obstruction (CNLDO) is one of the main causes of epiphora in infants, and antibiotics are usually used as a conservative therapy in the first year. Yet, little is known about the bacteriology of the occluded lacrimal drainage system in this group of patients. The aim of this study was to evaluate the microbiology of lacrimal sac (LS) in Chinese children with CNLDO in their first year of life.Methods: Patients with CNLDO between May 1, 2017 and August 31, 2018 at a tertiary care children’s hospital were enrolled. The study recruited infants who received lacrimal probing under 1 year old, and refluxed discharge from LS was collected. Samples were cultured and susceptibility test was performed for positive culture.Results: Thirty-two patients with CNLDO were included. The ratio of male to female was 23:9. The mean age was 6.7 ± 2.4 (1.7-12) months. Positive cultures was identified in 87.5% of the sample, and presented 38 strains of bacteria. Mixed infection was identified in 10 (31.3%) children. Gram-positive bacteria accounted for 60.5% of all the strains, with Streptococcus (50%) being the most frequent species, whereas Haemophilus (21.1%) and Neisseriae (13.2%) were most common isolates for Gram-negative organisms. Methicillin-resistant Staphylococcus aureus (MRSA) was detected in 2 infants whose symptoms resolved by a routine probing. No difference of bacteriology pattern was detected between patients under 6 months old and those beyond. The pathogens were highly sensitive to chloramphenicol (88%) and levofloxacin (84%), but resistant to erythromycin (40%) and sulfamethoxazole (32%).Conclusions: Infants with CNLDO under 1 year of age presented predominance of Streptococcus as Gram-positive organism, and Haemophilus as Gram-negative organism. Levofloxacin was an active topical antibiotic agent with few chance of resistance especially for Chinese children. These findings could help clinicians choose optimal medicine for CNLDO as the conservative treatments.

scholarly journals Lacrimal sac bacteriology and susceptibility pattern in infants with congenital nasolacrimal duct obstruction in the 1st year of life: a cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiao-Yu Zheng ◽  
Bonnie Nga Kwan Choy ◽  
Ming-Ming Zhou ◽  
Cai-Ping Shi ◽  
Zheng-Yan Zhao
Keyword(s):  
Tertiary Care ◽  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
Chinese Children ◽  
First Year ◽  
Lacrimal Sac ◽  
Gram Positive ◽  
Congenital Nasolacrimal Duct Obstruction ◽  
Gram Negative ◽  
Duct Obstruction

Abstract Background Congenital nasolacrimal duct obstruction (CNLDO) is one of the main causes of epiphora in infants, and antibiotics are usually used as a conservative therapy in the first year. Yet, little is known about the bacteriology of the occluded lacrimal drainage system in this group of patients. The aim of this study was to evaluate the microbiology of lacrimal sac (LS) in Chinese children with CNLDO in their first year of life. Methods Patients with CNLDO between May 1, 2017 and August 31, 2018 at a tertiary care children’s hospital were enrolled. The study recruited infants who received lacrimal probing under 1 year old, and refluxed discharge from LS was collected. Samples were cultured and susceptibility test was performed for positive culture. Results Thirty-two patients with CNLDO were included. The ratio of male to female was 23:9. The mean age was 6.7 ± 2.4 (1.7–12) months. Positive cultures was identified in 87.5% of the sample, and presented 38 strains of bacteria. Mixed infection was identified in 10 (31.3%) children. Gram-positive bacteria accounted for 60.5% of all the strains, with Streptococcus (50%) being the most frequent species, whereas Haemophilus (21.1%) and Neisseriae (13.2%) were most common isolates for Gram-negative organisms. Methicillin-resistant Staphylococcus aureus (MRSA) was detected in 2 infants whose symptoms resolved by a routine probing. No difference of bacteriology pattern was detected between patients under 6 months old and those beyond. The pathogens were highly sensitive to chloramphenicol (88%) and levofloxacin (84%), but resistant to erythromycin (40%) and sulfamethoxazole (32%). Conclusions Infants with CNLDO under 1 year of age presented predominance of Streptococcus as Gram-positive organism, and Haemophilus as Gram-negative organism. Levofloxacin was an active topical antibiotic agent with few chance of resistance especially for Chinese children. These findings could help clinicians choose optimal medicine for CNLDO as the conservative treatments.

scholarly journals Lacrimal Sac Bacteriology and Susceptibility Pattern in Infants with Congenital Nasolacrimal Duct Obstruction in the 1st Year of Life: A Cross-Sectional Study

2020 ◽  
Author(s):  
Xiaoyu Zheng ◽  
Bonnie Nga Kwan Choy ◽  
Mingming Zhou ◽  
Caiping Shi ◽  
Zhengyan Zhao
Keyword(s):  
Tertiary Care ◽  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
First Year ◽  
Lacrimal Sac ◽  
Gram Positive ◽  
Cross Sectional ◽  
Congenital Nasolacrimal Duct Obstruction ◽  
Gram Negative ◽  
Duct Obstruction

Abstract Background Congenital nasolacrimal duct obstruction (CNLDO) is one of the main causes of epiphora in infants, and antibiotics are usually used as a conservative therapy in the first year. Yet, little is known about the bacteriology of the occluded lacrimal drainage system in this group of patients. The aim of this study was to evaluate the microbiology of lacrimal sac (LS) in Chinese children with CNLDO in their first year of life. Methods Patients with CNLDO between May 1, 2017 and August 31, 2018 at a tertiary care children’s hospital were enrolled. The study recruited infants who received lacrimal probing under 1 year old, and refluxed discharge from LS was collected. Samples were cultured and susceptibility test was performed for positive culture. Results Thirty-two patients with CNLDO were included. The ratio of male to female was 1.5 : 1. The mean age was 6.6 ± 2.3 (1.7–12) months. Positive cultures was identified in 87.5% of the sample, and presented 38 strains of bacteria. Mixed infection was identified in 10 (35.7%) children. Gram-positive bacteria accounted for 60.5% of all the strains, with Streptococcus (50%) being the most frequent species, whereas Haemophilus (21.1%) and Neisseriae (13.2%) were most common isolates for Gram-negative organisms. Methicillin-resistant Staphylococcus aureus (MRSA) was detected in 2 infants whose symptoms resolved by a routine probing. No difference of bacteriology pattern was detected between patients under 6 months old and those beyond. The pathogens were highly sensitive to chloramphenicol (88%) and levofloxacin (84%), but resistant to erythromycin (40%) and sulfamethoxazole (32%). Conclusions Infants with CNLDO under 1 year of age presented predominance of Streptococcus as Gram-positive organism, and Haemophilus as Gram-negative organism. Levofloxacin was an active topical antibiotic agent with few chance of resistance. These findings could help clinicians choose optimal medicine for CNLDO as the conservative treatments.

scholarly journals Lacrimal Sac Bacteriology and Susceptibility Pattern in Infants with Congenital Nasolacrimal Duct Obstruction in the 1st Year of Life: A Cross-Sectional Study 

2020 ◽  
Author(s):  
Xiaoyu Zheng ◽  
Bonnie Nga Kwan Choy ◽  
Mingming Zhou ◽  
Caiping Shi ◽  
Zhengyan Zhao
Keyword(s):  
Tertiary Care ◽  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
Chinese Children ◽  
First Year ◽  
Lacrimal Sac ◽  
Gram Positive ◽  
Congenital Nasolacrimal Duct Obstruction ◽  
Gram Negative ◽  
Duct Obstruction

Abstract Background: Congenital nasolacrimal duct obstruction (CNLDO) is one of the main causes of epiphora in infants, and antibiotics are usually used as a conservative therapy in the first year. Yet, little is known about the bacteriology of the occluded lacrimal drainage system in this group of patients. The aim of this study was to evaluate the microbiology of lacrimal sac (LS) in Chinese children with CNLDO in their first year of life.Methods: Patients with CNLDO between May 1, 2017 and August 31, 2018 at a tertiary care children’s hospital were enrolled. The study recruited infants who received lacrimal probing under 1 year old, and refluxed discharge from LS was collected. Samples were cultured and susceptibility test was performed for positive culture.Results: Thirty-two patients with CNLDO were included. The ratio of male to female was 23:9. The mean age was 6.7 ± 2.4 (1.7-12) months. Positive cultures was identified in 87.5% of the sample, and presented 38 strains of bacteria. Mixed infection was identified in 10 (31.3%) children. Gram-positive bacteria accounted for 60.5% of all the strains, with Streptococcus (50%) being the most frequent species, whereas Haemophilus (21.1%) and Neisseriae (13.2%) were most common isolates for Gram-negative organisms. Methicillin-resistant Staphylococcus aureus (MRSA) was detected in 2 infants whose symptoms resolved by a routine probing. No difference of bacteriology pattern was detected between patients under 6 months old and those beyond. The pathogens were highly sensitive to chloramphenicol (88%) and levofloxacin (84%), but resistant to erythromycin (40%) and sulfamethoxazole (32%).Conclusions: Infants with CNLDO under 1 year of age presented predominance of Streptococcus as Gram-positive organism, and Haemophilus as Gram-negative organism. Levofloxacin was an active topical antibiotic agent with few chance of resistance especially for Chinese children. These findings could help clinicians choose optimal medicine for CNLDO as the conservative treatments.

scholarly journals Conservative Treatment for Congenital Nasolacrimal Duct Obstruction – Factors Affecting the Success

2021 ◽  
Vol 48 (2) ◽  
pp. 25-28
Author(s):  
K. P. Valcheva ◽  
S. V. Murgova
Keyword(s):  
Conservative Treatment ◽  
Clinical Signs ◽  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
Congenital Nasolacrimal Duct Obstruction ◽  
Factors Affecting ◽  
Duct Obstruction ◽  
Nonsurgical Management ◽  
History Of ◽  
A Prospective Study

Abstract Aim To examine the success rate and factors affecting the effect of conservative treatment for congenital nasolacrimal duct obstruction (CNLDO) in children. Methodology A prospective study was made on 167 eyes of 131 patients with clinical signs of CNLDO. All of them were initially treated nonsurgically with Crigler massage. The curative effect of this management was evaluated on the basis of no history of watery eyes, negative regurgitation test, and dye disappearance test 0 or 1 grade. Exploratory analyses assessed whether baseline characteristics including age, gender and laterality were associated with the probability of CNLDO resolving without surgery. If the nonsurgical treatment failed, probing was done in the Eye Clinic in Pleven. Results The conservative treatment for CNLDO with Crigler massage was successful in the majority of treated cases – in 115 out of 167 eyes with CNLDO (68,9%). The remaining 52 (31,1%) eyes were probed. Age (p = 0,001) and laterality (p = 0,001) were found to be associated with resolution of the clinical signs. Conclusions Nonsurgical management for CNLDO was successful initial treatment in patients with this pathology. The Crigler massage was more effective in children up to 12 months of age with unilateral obstruction.

Microbiological spectrum of microbial keratitis in patients presenting with nasolacrimal duct obstruction

2020 ◽  
pp. 112067212094057
Author(s):  
Supriya Sharma ◽  
Srikant K Sahu ◽  
Suryasnata Rath ◽  
Aparajita Mallick ◽  
Savitri Sharma ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antibiotic Susceptibility ◽  
Nasolacrimal Duct ◽  
Nasolacrimal Duct Obstruction ◽  
Coagulase Negative Staphylococcus ◽  
Microbial Keratitis ◽  
Gram Positive ◽  
Antibiotic Susceptibility Pattern ◽  
Duct Obstruction ◽  
Gram Positive Bacteria

Purpose: To study the type of bacteria and their antibiotic susceptibility pattern from corneal scrapings of patients with infectious keratitis presenting with concurrent nasolacrimal duct obstruction. Methods: A retrospective analysis was carried out of patients with microbial keratitis and co-existing nasolacrimal duct obstruction during a 5-year period (January 2012 to December 2016). Antibiotic susceptibility profile data was collected from the microbiology records. Results: The study included 56 (M:F = 33:23; OD:OS = 34:22) eyes. The mean age of patients was 60.2 ± 12.3 years. Microscopic examination of corneal scrapings showed 52% of gram-positive ( n = 29/55) and 2% of multiple (>1; n = 1/55) bacteria. Streptococcus pneumoniae (32%, n = 18/56), coagulase-negative Staphylococcus (25%, n = 14/56), and Staphylococcus aureus (11%, n = 6/56) were the most common bacteria. Streptococcus pneumoniae was found to be susceptible to ciprofloxacin (72.2%), ofloxacin (94.4%), gatifloxacin (61.1%), and moxifloxacin (83.3%). Conclusion: Corneal infection associated with nasolacrimal duct obstruction is commonly caused by gram-positive-bacteria. Irrigation of nasolacrimal duct should be mandatory test in microbial keratitis. The gram-positive bacteria isolated showed maximum susceptibility to vancomycin and cefazolin. Early treatment by surgery and appropriate medical management is recommended for its control.

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