“CYTOMORPHOLOGICAL PATTERNS OF TUBERCULOUS LYMPHADENITIS AND ITS CORRELATION WITH ZIEHL-NEELSEN STAINING AND CBNAAT IN A TERTIARY CARE CENTRE OF HARYANA”

2021 ◽  
pp. 73-75
Author(s):  
Singh S ◽  
Arora S ◽  
Munesh Munesh ◽  
Mahajan S
Keyword(s):  
Developing Countries ◽  
Tertiary Care ◽  
Diagnostic Technique ◽  
Needle Aspiration ◽  
Tuberculous Lymphadenitis ◽  
Tertiary Care Centre ◽  
Adequate Treatment ◽  
Caseous Necrosis ◽  
Cytological Features ◽  
Needle Aspiration Cytology

Introducion: Tuberculosis (TB) is still prevalent in developing countries, and one of the most common cause of tuberculous lymphadenopathy. Quick diagnosis is necessary for adequate treatment. Fine needle aspiration cytology (FNAC) is an efcient and rapid primary diagnostic technique as an alternative to excision. Cytomorphologic features of well-formed epithelioid granulomas and the presence of caseous necrosis are sufcient for cytological diagnosis. Mycobacteriological conrmation however, is essential to rule out other causes of granulomatous inammation. Material and methods: This study was aimed at evaluating and correlating the role of FNAC, mycobacterium recognition by Ziehl-Neelsen staining (ZN staining) with Cartridge based nucleic acid amplication test (CBNAAT) positivity to diagnose tuberculous lymphadenitis. FNA material was collected from 97 patients and was analysed by cytomorphology, ZN stain and CBNAAT. Result: Out of 97 cases, 66 cases had cytological features consistent with TB. 40.9% of the smears showed epithelioid granulomas with caseous necrosis, followed by 31.8% smears showing epithelioid granuloma without necrosis and necrosis with polymorphs without granuloma in 27.3% of the smears. Amongst the 27 cases showing granuloma with necrosis, there was 44.4% AFB positivity and 48.1% CBNAAT positivity while 21 cases of granuloma without necrosis showed 52.3% AFB positivity and 47.6% CBNAAT positivity. In the 18 cases showing necrosis there was 72.2% AFB positivity and 83.3% CBNAATpositivity. Conclusion: The presence of caseous necrosis and granulomas are strongly suggestive of tubercular etiology, especially in developing countries with high incidence of TB. AFB smear CBNAATcan supplement cytomorphometry for rapid and accurate diagnosis.

scholarly journals Tubercular mastitis: An institutional experience from a tertiary care centre of northern India

2017 ◽  
Vol 8 (3) ◽  
pp. 72-75
Author(s):  
Amit Gupta ◽  
Lovenish Bains ◽  
Deepshikha Yadav ◽  
Prashant Durgapal ◽  
Manish Kumar Agrawal
Keyword(s):  
Tertiary Care ◽  
Needle Aspiration ◽  
Care Centre ◽  
Medical Sciences ◽  
Tertiary Care Centre ◽  
Aspiration Cytology ◽  
Northern India ◽  
Institutional Experience ◽  
Needle Aspiration Cytology ◽  
High Index Of Suspicion

Background: Tuberculous mastitis (TM) is a rare extra pulmonary presentation of tuberculosis. It may be problematic to distinguish from carcinoma breast, a condition with which it may coexist.  Fine needle aspiration cytology (FNAC) / biopsy are indispensable for diagnosis and tuberculosis culture when positive may be very valuable to guide antimicrobial therapy.Aims and Objectives:  To disseminate the message to the concerned expertise that it can present a diagnostic problem on radiological and microbiological investigations, and thus a high index of suspicion is needed.Materials and Methods: 19 cases of tubercular mastitis between  January 2012 to March 2014 were identified and included in the present study. Cytology and biopsy alongwith AFB stain was done for confirmation.Results: Age ranged between 23- 55 years (median 33 years). Axillary nodes were palpable in 9 (47.3%) patients. Acid Fast Bacilli stain which was positive in only 3 patients. All the 19 patients were started on antitubercular treatment.Conclusion: This study highlights the importance of early diagnosis and aggressive medical and if required surgical management to cure this disease.Asian Journal of Medical Sciences Vol.8(3) 2017 72-75

scholarly journals Correlation between cytomorphology and acid fast bacilli positivity in tubercular lymphadenopathy in far Western Nepal: a hospital based study

2020 ◽  
Vol 8 (8) ◽  
pp. 2933
Author(s):  
Ashok Shreepaili ◽  
Sushil Dhakal
Keyword(s):  
Lymph Nodes ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Tuberculous Lymphadenitis ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Caseous Necrosis ◽  
Needle Aspiration Cytology ◽  
Tubercular Lymphadenitis

Background: Tuberculous lymphadenitis is the most common manifestation of extrapulmonary tuberculosis. Fine needle aspiration cytology (FNAC) is a valuable tool in diagnosis of tubercular lymphadenitis. The present study aims to determine the prevalence of different cytomorphological patterns in fine needle aspiration cytology of tubercular lymph nodes and their correlation with Acid Fast Bacilli (AFB) positivity on Ziehi-Neelsen (ZN) Staining.Methods: Fine needle aspiration cytology of 274 cases diagnosed as tubercular lymphadenitis over a period of a year were reviewed. Cytomorphological patterns were categorized into three patterns. Pattern I: Epithelioid granuloma without necrosis, Pattern II: Epithelioid granuloma with caseous necrosis and Pattern III: Caseous necrosis only. Fischer Exact test was applied to correlate cytomorphological pattern and AFB positivity.Results: Tuberculous lymphadenitis was most frequent in age group 21-30 years (24.81%). Cervical lymph nodes were the most frequent lymph nodes involved (84.67%). Pattern I was the most common cytomorphological pattern observed (49.3%). Overall AFB positivity was 28.10%. Maximum AFB positivity was seen in pattern III (73.3%).Conclusions: FNAC is the simple, cost effective and minimally invasive tool to diagnose tuberculous lymphadenitis. Study of both cytomorphological pattern and ZN staining for AFB can improve the diagnostic accuracy.

scholarly journals Clinicopathological Study of Mucinous Carcinoma of Breast with Emphasis on Cytological Features: A Study at Tertiary Care Teaching Hospital of South India

2020 ◽  
Vol 12 (01) ◽  
pp. 68-75
Author(s):  
Panduranga Chikkannaiah ◽  
Deinu Thangngeo ◽  
Chanigaramaiah Guruprasad ◽  
Srinivasamurthy Venkataramanappa
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Tertiary Care ◽  
Mucinous Carcinoma ◽  
Needle Aspiration ◽  
Lymph Node Involvement ◽  
Lymph Node Status ◽  
Cytological Features ◽  
The Mean ◽  
Needle Aspiration Cytology

Abstract Introduction Mucinous carcinoma (MC) is a rare form of breast cancer. It accounts for 1 to 7% of the cases and characterized by the presence of extracellular mucin (ECM). Depending on the amount of mucin, it is classified into pure mucinous carcinoma (> 90%, PMC) and mixed mucinous carcinoma (MMC; < 90%). In comparison to most common subtypes, MC is having better prognosis. There exist clinicopathological differences among PMC and MMC and also MC and IDC-NOS. Materials and Methods MCs diagnosed between January 2012 and December 2017 were included. Fine needle aspiration cytology smears were screened for cellularity, ECM, nuclear pleomorphism, signet ring cells (SRC), mucinophages, and myxovascular fragments (MVF). Histopathology slides were screened to confirm the diagnosis. Immunohistochemistry slides were graded as per the standard protocol. Statistical analyses were performed by SPSS software. Results In the present study, MC constituted 3.3%. The mean age of the patients was 50.9 years. ECM, mucinophages, and SRC were the key diagnostic cytological features. The PMC and MMC were clinicopathologically distinct with respect to gross findings and lymph node status. MMCs were highly proliferative. The mean duration of follow-up was 24.5 months. Complications were more common in MMC than PMC. Lymph node involvement is the key prognostic factor and it is independent of other prognostic factors like age, size, and hormonal receptor status. Conclusion PMC are rare subtype of breast cancer. The diagnostic cytological features are ECM, MVF, and SRC. MMC and PMC are clinicopathologically and genetically distinct.

CYTOPATHOLOGICAL SPECTRUM OF NON NEOPLASTIC AND NEOPLASTIC THYROID LESIONS AT TERTIARY CARE CENTRE, GWALIOR

2021 ◽  
pp. 13-15
Author(s):  
Sapna Dhakad ◽  
Shailendra Sharma ◽  
Diljeet Kaur
Keyword(s):  
Malignant Tumors ◽  
Tertiary Care ◽  
Diagnostic Technique ◽  
Hashimoto Thyroiditis ◽  
Needle Aspiration ◽  
Follicular Neoplasm ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Thyroid Lesion ◽  
Thyroid Lesions

Background: Thyroid lesions are the important clinical problems encountered in most of patients coming to the tertiary care centre. Fine Needle Aspiration Cytology (FNAC) is the widely accepted diagnostic technique in thyroid lesions. A solitary thyroid nodule is dened as a palpable, single, clinically detectable nodule in the thyroid. They cause more concern because of high probability of malignancy in them, which can range from 5-35% of all solitary thyroid nodules. Nodular lesion comprises those disorders that produce a clinical nodule and consists of non-neoplastic hyperplasia as well as benign and malignant tumors. Aims and Objectives:To study the spectrum of clinical presentation of individuals with thyroid lesions and cytomorphological features. Material and methods: A retrospective study was carried out in cytopathology section in Department of Pathology from January 2015 to December 2017. Total 212 patients with palpable thyroid swelling referred from the OPD of J.A hospital for FNAC were included in the study. The smears made from the aspirate were air dried and stained with May-Grunwald-Giemsa (MGG) stain. Result: The present study was carried out in the Department of Pathology from January 2015 to December 2017. Out of 212 cases most common thyroid lesion was Colloid goitre 35.38%(n=75) followed by Colloid goitre with cystic changes 19.81%(n=42), Follicular Neoplasm 19.34%(n=41), Hashimoto thyroiditis 7.55%(n=16), Colloid cyst 6.13%(n=13), Infected cystic lesion 2.83%(n=6), Benign hyperplasia of thyroid 2.36%(n=5), Adenomatoid goitre 1.89%(n=4), Thyroglossal cyst 1.89%(n=4), Granulomatous thyroiditis 1.41%(n=3), Papillary thyroid carcinoma 0.94%(n=2) and least common was Lymphoma of thyroid 0.47%(n=1). Conclusion: FNAC is almost an accurate technique in diagnosis of palpable and overt thyroid lesions. Thyroid lesions are more common in females than males. Colloid goitre is the commonest thyroid lesion.

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