scholarly journals Intensive initiation of insulin therapy in patients with newly diagnosed type 2 diabetes mellitus: a different take on current stepwise approaches

2020 ◽  
pp. 111-114
Author(s):  
D Wolmarans ◽  
S Steyn ◽  
L Brand
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Architecture ◽  
Subsequent Treatment ◽  
Newly Diagnosed ◽  
Lifestyle Choices ◽  
Oral Hypoglycaemic Drugs ◽  
Genetic Constructs

Type 2 diabetes mellitus (T2DM), previously regarded as being a disease borne exclusively from following a poor lifestyle, affects at least 415 million individuals worldwide, a number which is believed will increase to 640 million by 2040. As our understanding of T2DM improved over time, it became clear that the condition is underpinned by interactions between poor lifestyle choices and highly varying genetic constructs that involve more than 400 genes. Although a comprehensive review of the genetic architecture of T2DM falls beyond the scope of the current paper, it suffices to say that failure to regard the pathophysiology of T2DM and its subsequent treatment from a drastically different perspective, will result in an increasing burden of the condition on society. This is especially realistic, since despite the fact that oral hypoglycaemic drugs have been used since 1955, current approaches fail to arrest the continuous global rise in the number of T2DM cases.

Circulating Netrin-1 as a Novel Biomarker for Impaired Fasting Glucose and Newly Diagnosed Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1535-P ◽  
Author(s):  
HYE-IN JUNG ◽  
JAEHYUN BAE ◽  
EUGENE HAN ◽  
GYURI KIM ◽  
JI-YEON LEE ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Newly Diagnosed

scholarly journals Effect of Sitagliptin on Serum Irisin Levels in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

2021 ◽  
Vol 12 (4) ◽  
pp. 1029-1039
Author(s):  
Qiu Wang ◽  
Lirong Ma ◽  
Yuanying Zhang ◽  
Lin Zhang ◽  
Yu An ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Newly Diagnosed

Increased Serum WISP1 Levels are Associated with Lower Extremity Atherosclerotic Disease in Patients with type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Yangyang Cheng ◽  
Xiaohui Du ◽  
Bilin Zhang ◽  
Junxia Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lower Extremity ◽  
Interleukin 6 ◽  
Atherosclerotic Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diabetic Patients ◽  
Newly Diagnosed

Abstract Background Serum wnt1-induced signaling pathway protein 1 (WISP1) levels are increased with obesity, which is a common complication associated with lower extremity atherosclerotic disease (LEAD). However, to date, the relationship between elevated WISP1 levels and the incidence of lower extremity atherosclerotic disease (LEAD) in type 2 diabetes mellitus (T2DM) remains unclear. Methods 174 newly diagnosed type 2 diabetic patients were enrolled in our study. Patients were divided into two groups, LEAD group (n=100) and control group (n=74). Anthropometric parameters, blood pressure and some biochemical parameters were obtained. Body composition was detected by bioelectrical impedance analysis (BIA). Levels of serum insulin were determined by radioimmunoassay. Serum WISP1 and interleukin 6 (IL-6) levels were determined using an enzyme-linked immunosorbent assay. Results It was shown that serum WISP1 levels in diabetic patients with LEAD were higher than those without LEAD (P<0.001). Serum WISP1 levels were positively related with waist circumference (r=0.237, P=0.003), waist-hip ratio (r=0.22, P=0.006), visceral fat area (r=0.354, P<0.001), serum creatinine (r=0.192, P=0.012), interleukin 6 (r=0.182, P=0.032), c-reactive protein (r=0.681, P<0.001), triglycerides (r=0.119, P<0.001), fasting glucose (r=0.196, P=0.011), glycated hemoglobin (r=0.284, P<0.001), and HOMA-IR (r=0.285, P<0.026). Compared with the lowest tertile, the odds ratio of the middle tertile for LEAD incidence was 3.27 (95% CI, 1.24–8.64) and 4.46 (95% CI, 1.62–12.29) for the highest tertile after adjusting confounding factors. Conclusion The results suggest that increased serum WISP1 levels independently contribute to the incidence of LEAD in patients with newly diagnosed T2DM.

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